DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3376 and Smpdl3b

DIOPT Version :9

Sequence 1:	NP_001246491.1	Gene:	CG3376 / 37884	FlyBaseID:	FBgn0034997	Length:	764	Species:	Drosophila melanogaster
Sequence 2:	NP_001020908.1	Gene:	Smpdl3b / 362619	RGDID:	1307458	Length:	456	Species:	Rattus norvegicus

Alignment Length:	418	Identity:	122/418 - (29%)
Similarity:	190/418 - (45%)	Gaps:	50/418 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   303 HISDTHYDPHYAEGSNADCNEPLCCRLSSGRPATPNAAAGKWGDYRKCDTPKRTVDHMLSHIAET 367
            ||||.|.||:|...     .:||  |:.....:.|...||.|||| .||:|...::..:..:.|.
  Rat    25 HISDLHLDPNYTVS-----KDPL--RVCPSAGSQPVLNAGPWGDY-LCDSPWALINSSIYAMKEI 81

  Fly   368 HKDIDYILWTGDLPPHDVWNQTKEEN--LAIIKDTVKQMVEMFPGVPIFPALGNHESAPVNSFPP 430
            ....|:|.||||..|| |.|:...|.  |:::......:.|:|||..::.|||||:..|.|..|
  Rat    82 EPKPDFIFWTGDDTPH-VPNERLGEGAVLSMVDRLTNLIKEVFPGTKVYAALGNHDFHPKNQLP- 144

  Fly   431 PYVNQVDISISWLYDELDIQWRRWLPQSVTHTVRRGAFYS-VLVRPG--FRIISLNMN--YCNNK 490
                   ...:.:|..:...||.||........:.||||| .|..|.  .|::.||.|  |.:|:
  Rat   145 -------AQSNSIYTHVAELWRPWLSNESFTLFKEGAFYSEKLPSPSKTGRVVVLNTNLYYSSNE 202

  Fly   491 NWWLLLNSTDPATELQWFIYELQSAEFSNEKVHVIGHIPPGHSDCL--KVWSR-----NFYKIIS 548
            .   .....||..:.||....|.:|..:.|.|::|||:|||..:..  |.|.|     .:.|::.
  Rat   203 Q---TAGMADPGQQFQWLGDVLSNASRNGEMVYIIGHVPPGFFEKTQDKAWFRESFNEEYLKVVQ 264

  Fly   549 RYESTVTAQFYGHTHYDEFEMFYDPHDLNHPNGIAYIGPSVSPYYDLNPGYRIYYVDG------- 606
            ::...:..||:||.|.|.|.|||.  ....|..:.::.|.|:|:....||    .|||
  Rat   265 QHHRVIAGQFFGHHHTDSFRMFYS--STGAPISVMFLTPGVTPWKTTLPG----VVDGANNPAIR 323

  Fly   607 --DHDATTRLVIDHESWIMNLKEANLYGYPIWYKLYTARAAYNMKALRPSDWNNLLNELTNNQEL 669
              ::|..|..:.|..::.:||::|:....|.|.:.|....||.::....|.....|..:.:.|.:
  Rat   324 IFEYDRATLNLKDMVTYYLNLRQADTQETPQWEQEYRLTEAYEVQDASTSSMYTALTRIASEQHI 388

  Fly   670 FELYYKYYWKNSPARPTCDAECKKRLIC 697
            .:.||.|...:...:| |:..|::..:|
  Rat   389 LQRYYVYNSVSYSHQP-CEDVCRREHVC 415

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3376	NP_001246491.1	SapB	186..258	CDD:214797
		Metallophos	299..563	CDD:278574	86/273 (32%)
		MPP_ASMase	301..600	CDD:277321	98/310 (32%)
Smpdl3b	NP_001020908.1	Metallophos	22..281	CDD:278574	87/275 (32%)
Smpdl3b	NP_001020908.1	MPP_ASMase	23..323	CDD:277321	101/323 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3770
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53732
OrthoDB	1	1.010	-	-		D369165at33208
OrthoFinder	1	1.000	-	-		FOG0000551
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.830