Protein Alignment CG3376 and Smpd1

DIOPT Version :10

• Sequence 1: NP_001246491.1
• Gene: CG3376 / 37884
• FlyBaseID: FBgn0034997
• Length: 764
• Species: Drosophila melanogaster
• Sequence 2: NP_001006998.1
• Gene: Smpd1 / 308909
• RGDID: 1549719
• Length: 627
• Species: Rattus norvegicus
• Alignment Length: 578
• Identity: 238/578 - (41%)
• Similarity: 346/578 - (59%)
• Gaps: 28/578 - (4%)

  Fly   142 SRMLWYDVAGGDGLVYP-PFVDKALKLLNLKQVAFEIENSV-MSKVTCTACRAGAGMLQHQIQSG 204
            |.:||....     .|| |....::|   ...||.:::|:. ...:||.||:.....|.:.::..
  Rat    48 STVLWVPAR-----AYPLPSQGHSVK---FSAVAPQLQNAFGWRNLTCPACKVLFTALNYGLKKE 104

  Fly   205 KTDAELIRMITDYCTNLNIQSARVCQGVAQLFGSELIYVLKRVNLSPDELCSFVIGDGCA--DVY 267
            ...|.:..:....|..|||....|||....||..:::.|..|..|||.|.|..::|..|.  |::
  Rat   105 PNVARVGSVAIKMCKMLNIAPLNVCQSAVHLFEDDVVDVWTRSVLSPSEACGLLLGSSCGHWDIF 169

  Fly   268 NPYHEWEVIFPPVPKPPRLPDLPIPMEAAPFFKVLHISDTHYDPHYAEGSNADCNEPLCCRLSSG 332
            :   .|.:..|.|||||..|..| |...||..:||.::|.|:|..|.||::.:|.:|||||..||
  Rat   170 S---TWNISLPSVPKPPPKPPSP-PAPGAPVSRVLFLTDLHWDHDYLEGTDPNCADPLCCRRGSG 230

  Fly   333 RPATPNAAAGKWGDYRKCDTPKRTVDHMLSHIAETHKDIDYILWTGDLPPHDVWNQTKEENLAII 397
            .|......||.||:|.|||.|.||::.:|..:... ...:.:.||||:|.||||.|::::.|..:
  Rat   231 WPPNSRTGAGYWGEYSKCDLPLRTLESLLKGLGPA-GPFEMVYWTGDIPAHDVWQQSRQDQLRAL 294

  Fly   398 KDTVKQMVEMFPG-VPIFPALGNHESAPVNSFPPPYV--NQVDISISWLYDELDIQWRRWLPQSV 459
             :|:..:|..|.| ||::||:|||||.|||.||||::  ||   |..|||:.:...|..|||...
  Rat   295 -NTITDLVWKFLGPVPVYPAVGNHESTPVNGFPPPFIKGNQ---SSQWLYEAMAKAWEPWLPADA 355

  Fly   460 THTVRRGAFYSVLVRPGFRIISLNMNYCNNKNWWLLLNSTDPATELQWFIYELQSAEFSNEKVHV 524
            .||:|.|.||::..|||.|:||||||:|:.:|:|||:||||||.:|||.:.|||:||...:|||:
  Rat   356 LHTLRIGGFYALTPRPGLRLISLNMNFCSRENFWLLINSTDPAGQLQWLVDELQAAENRGDKVHI 420

  Fly   525 IGHIPPGHSDCLKVWSRNFYKIISRYESTVTAQFYGHTHYDEFEMFYDPHDLNHPNGIAYIGPSV 589
            ||||||||  |||.||.|:||||:|||:|:..||:||||.||||:|||...|:.|..:|::|||.
  Rat   421 IGHIPPGH--CLKSWSWNYYKIIARYENTLAGQFFGHTHVDEFEIFYDEETLSRPLAVAFLGPSA 483

  Fly   590 SPYYDLNPGYRIYYVDGDHDATTRLVIDHESWIMNLKEANL-YGYPIWYKLYTARAAYNMKALRP 653
            :.:.:||||||:|.:||::..::.:|:|||::|:||.:||. .|.|.|.:||.||..|.:....|
  Rat   484 TTFINLNPGYRVYQIDGNYPGSSHVVLDHETYILNLTQANAPGGTPSWKRLYRARETYGLPDAMP 548

  Fly   654 SDWNNLLNELTNNQELFELYYKYYWKNSPARPTCDAECKKRLICDCRSGRSHDRKHFC 711
            :.|:||:..:..:::||:.::..|.|..|....|...|:...:|...|.|: |....|
  Rat   549 ASWHNLVYRMRADEQLFQTFWFLYHKGHPPSEPCGTPCRLATLCAQLSARA-DSPALC 605

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG3376	NP_001246491.1	SapB	186..258	CDD:214797	22/71 (31%)
		MPP_ASMase	301..600	CDD:277321	153/301 (51%)
		ASMase_C	584..697	CDD:466022	40/113 (35%)
Smpd1	NP_001006998.1	SapB	85..158	CDD:214797	22/72 (31%)
		MPP_ASMase	199..494	CDD:277321	153/301 (51%)
		ASMase_C	472..593	CDD:466022	42/120 (35%)