DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3376 and asm-1

DIOPT Version :9

Sequence 1:	NP_001246491.1	Gene:	CG3376 / 37884	FlyBaseID:	FBgn0034997	Length:	764	Species:	Drosophila melanogaster
Sequence 2:	NP_495415.2	Gene:	asm-1 / 174131	WormBaseID:	WBGene00000211	Length:	564	Species:	Caenorhabditis elegans

Alignment Length:	564	Identity:	194/564 - (34%)
Similarity:	305/564 - (54%)	Gaps:	33/564 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly   167 LLNLKQVAFEIENSVMSKVT---------CTACRAGAGMLQHQIQSGKTDAELIRMITDYCTNLN 222
            |:.........:.|:.:|||         |.:|.....:....::...::..::...|..|....
Worm    12 LIYTNATVLRTKESIQNKVTYDKYGFQPLCISCTGLISVASFFLKFDVSEPVILEFATIVCKLFA 76

  Fly   223 IQSARVCQGVAQLFGSELIYVLKRV-NLSPDELCSFVIGDGCADVYNPYHE-WEVIFPPVPKPPR 285
            .|...||.|::..|..|..||.:|: |.||.::|..::.| |||..:|... |.|..||.||..|
Worm    77 KQPWAVCDGISSQFRDEFFYVFRRLANESPSQICGIILPD-CADPTDPSESGWMVALPPKPKRTR 140

  Fly   286 LPDLPIP----MEAAPFFKVLHISDTHYDPHYAEGSNADCNEPLCCRLSSGRPATPNAAAGKWGD 346
            :....:.    |..:....||.::|.|.|..|...|.|:|::|:|||:|   .:.|..|||.||.
Worm   141 ISKKKVQKKPNMSMSQNLNVLQLTDLHVDFEYKYPSEANCDDPVCCRVS---VSEPKKAAGYWGS 202

  Fly   347 YRKCDTPKRTVDHMLSHIAETHKDIDYILWTGDLPPHDVWNQTKEENLAIIKDTVKQMVEMFPGV 411
            ..|||.|..||::|||||.:||. ||.::.|||...|..|..:.||:|::::...:.:...||..
Worm   203 VGKCDIPFWTVENMLSHINKTHM-IDMVIMTGDYINHVDWEYSIEEHLSVLRKLHRLVQNTFPST 266

  Fly   412 PIFPALGNHESAPVNSFPPPYVNQVDISI--SWLYDELDIQWRRWLPQSVTHTVRRGAFYSVLVR 474
            ||:.||||||..|||||.|   :.||...  :|||.|.......||.:....::.:...||..|.
Worm   267 PIYWALGNHEGVPVNSFAP---HSVDERFWPTWLYKEFQTMSGPWLSEGAKDSLLKRGSYSTQVM 328

  Fly   475 PGFRIISLNMNYCNNKNWWLLLNSTDPATELQWFIYELQSAEFSNEKVHVIGHIPPGHSDCLKVW 539
            .|.::|:||..:|...|::|.||.:||.:.:.||:.||..:|...|:|:|:.|||||.|:||:.|
Worm   329 DGLKLITLNTGFCEVTNFFLYLNQSDPDSSMSWFVKELFESEKKGEQVYVLAHIPPGDSECLEGW 393

  Fly   540 SRNFYKIISRYESTVTAQFYGHTHYDEFEMFY-DPHDL-NHPNGIAYIGPSVSPYYDLNPGYRIY 602
            :.|:|::|.|:.||:.|||:||.|.|.|.:|| |.|:: :.|..:.|..|||:.:...||.||||
Worm   394 AFNYYRVIQRFSSTIAAQFFGHDHLDYFTVFYEDMHNVSSKPISVGYASPSVTTFEYQNPAYRIY 458

  Fly   603 YVDGDHDATTRLVIDHESWIMNLKEANLYGYPIWYKLYTARAAYNMKALRPSDWNNLLNELTNNQ 667
            .:|..:...   ::|..::..:|::|.....|:|.|||:||.|:.|..|.|..||.::.:|..::
Worm   459 EIDPYNKFK---IVDFTTYYADLEKATEDKKPVWEKLYSARQAHGMDDLSPLSWNKVIQKLFTSE 520

  Fly   668 ELFELYYKYYWKNSPARPTCDAECKKRLICDCRSGRSHDRKHFC 711
            :..|.:|:|.::|  ..|.||:.|:.:|:|:.|.|. |:...:|
Worm   521 KKREKFYQYAFRN--FSPQCDSTCQMQLMCNLRMGH-HNSTLYC 561

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3376	NP_001246491.1	SapB	186..258	CDD:214797	18/81 (22%)
		Metallophos	299..563	CDD:278574	109/265 (41%)
		MPP_ASMase	301..600	CDD:277321	123/302 (41%)
asm-1	NP_495415.2	SapB	39..113	CDD:214797	17/73 (23%)
		MPP_ASMase	160..456	CDD:277321	123/302 (41%)
		Metallophos	210..417	CDD:278574	85/210 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160160975
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3770
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53732
OrthoDB	1	1.010	-	-		D1142100at2759
OrthoFinder	1	1.000	-	-		FOG0000551
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101180
Panther	1	1.100	-	-	O	PTHR10340
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R975
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.790