DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3376 and Smpdl3b

DIOPT Version :9

Sequence 1:	NP_001246491.1	Gene:	CG3376 / 37884	FlyBaseID:	FBgn0034997	Length:	764	Species:	Drosophila melanogaster
Sequence 2:	NP_598649.1	Gene:	Smpdl3b / 100340	MGIID:	1916022	Length:	456	Species:	Mus musculus

Alignment Length:	434	Identity:	135/434 - (31%)
Similarity:	204/434 - (47%)	Gaps:	56/434 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   290 PIPMEAAPFFKVLHISDTHYDPHYAEGSNADCNEPLCCRLSSGRPATPNAAAGKWGDYRKCDTPK 354
            |..:..|...:..||||.|.||:|...     .:||....|:|  :.|...||.|||| .||:|.
Mouse    12 PWGVAGAQLGRFWHISDLHLDPNYTVS-----KDPLQVCPSAG--SQPVLNAGPWGDY-LCDSPW 68

  Fly   355 RTVDHMLSHIAETHKDIDYILWTGDLPPHDVWNQTKEEN--LAIIKDTVKQMVEMFPGVPIFPAL 417
            ..::..|..:.|.....|:||||||..|| |.|::..|.  |||::.....:.|:||...::.||
Mouse    69 ALINSSLYAMKEIEPKPDFILWTGDDTPH-VPNESLGEAAVLAIVERLTNLIKEVFPDTKVYAAL 132

  Fly   418 GNHESAPVNSFPPPYVNQVDISISWLYDELDIQWRRWLPQSVTHTVRRGAFYSVLVRPG----FR 478
            |||:..|.|.||        ...:.:|:::...||.||........:||||||..: ||    .|
Mouse   133 GNHDFHPKNQFP--------AQSNRIYNQVAELWRPWLSNESYALFKRGAFYSEKL-PGPSRAGR 188

  Fly   479 IISLNMN--YCNNKNWWLLLNSTDPATELQWFIYELQSAEFSNEKVHVIGHIPPGHSDCL--KVW 539
            ::.||.|  |.||:.   .....||..:.:|....|.:|....|.|:||||:|||..:..  |.|
Mouse   189 VVVLNTNLYYSNNEQ---TAGMADPGEQFRWLGDVLSNASRDGEMVYVIGHVPPGFFEKTQNKAW 250

  Fly   540 SR-----NFYKIISRYESTVTAQFYGHTHYDEFEMFYDPHDLNHPNGIAYIGPSVSPYYDL---- 595
            .|     .:.|:|.::...:..||:||.|.|.|.||||  :...|..:.::.|.|:|:...
Mouse   251 FRESFNEEYLKVIQKHHRVIAGQFFGHHHTDSFRMFYD--NTGAPINVMFLTPGVTPWKTTLPGV 313

  Fly   596 -----NPGYRIYYVDGDHDATTRLVIDHESWIMNLKEANLYGYPIWYKLYTARAAYNMKALRPSD 655
                 |||.||:    ::|..|..:.|..::.:||::||:...|.|.:.|....||.:.....|.
Mouse   314 VDGANNPGIRIF----EYDRATLNLKDLVTYFLNLRQANVQETPRWEQEYRLTEAYQVPDASVSS 374

  Fly   656 WNNLLNELTNNQELFELYYKYYWKNSPA--RPTCDAECKKRLIC 697
            .:..|..:.:...:.:.||.|   ||.:  ..||:..|:...:|
Mouse   375 MHTALTRIASEPHILQRYYVY---NSVSYNHLTCEDSCRIEHVC 415

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3376	NP_001246491.1	SapB	186..258	CDD:214797
		Metallophos	299..563	CDD:278574	94/278 (34%)
		MPP_ASMase	301..600	CDD:277321	108/322 (34%)
Smpdl3b	NP_598649.1	Metallophos	22..281	CDD:278574	95/279 (34%)
Smpdl3b	NP_598649.1	MPP_ASMase	23..323	CDD:277321	108/322 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3770
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53732
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000551
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R975
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.850