Protein Alignment CG13575 and TACR3

DIOPT Version :9

• Sequence 1: NP_611903.1
• Gene: CG13575 / 37883
• FlyBaseID: FBgn0034996
• Length: 521
• Species: Drosophila melanogaster
• Sequence 2: NP_001050.1
• Gene: TACR3 / 6870
• HGNCID: 11528
• Length: 465
• Species: Homo sapiens
• Alignment Length: 520
• Identity: 109/520 - (20%)
• Similarity: 191/520 - (36%)
• Gaps: 154/520 - (29%)

  Fly    25 ATPIPSIQPYPGVFVGDLSQLNRFKRHA-----FSAVVGTLFVLAFCGNLSTLY-VNSRRKLRPF 83
            |:|.|| ||:..:       .|:|.:.:     :|...|.:..:|..|||..:: :.:.:::|..
Human    63 ASPAPS-QPWANL-------TNQFVQPSWRIALWSLAYGVVVAVAVLGNLIVIWIILAHKRMRTV 119

  Fly    84 FRACLISLACSDLVSSIFCT-VSYMAQFQAQYLQLWTIGGFMCKFVPFITTTSVLSGSLTLVAIA 147
            ....|::||.||...:.|.| |:::....::    |..|...|:|..|...|:|.:...::.|||
Human   120 TNYFLVNLAFSDASMAAFNTLVNFIYALHSE----WYFGANYCRFQNFFPITAVFASIYSMTAIA 180

  Fly   148 LDRYLAVMRPVLGFWSPDKRFSTLSMLLIWACSIGSSGPLLGIYDYRKIYLLDVEDSSEESEEVV 212
            :|||:|::.|:      ..|.|..:..::    |||            |::|          ..:
Human   181 VDRYMAIIDPL------KPRLSATATKIV----IGS------------IWIL----------AFL 213

  Fly   213 TAVPEELVVTELEMVHMCLA------GDHDVGLYYVILFTLIF-LPCIVSFLWLNAVIARQLWLR 270
            .|.|:.|......|....|.      |......|::|:..|:: .|.::..: ...::...||
Human   214 LAFPQCLYSKTKVMPGRTLCFVQWPEGPKQHFTYHIIVIILVYCFPLLIMGI-TYTIVGITLW-- 275

  Fly   271 RHYHQEQQEQHQEPKEGQFKTMANGGDLLMPSTLVSAMGVAVPFALDNTPLPPKSTVNAPGKKTT 335
                                    ||::                        |..|.:...::..
Human   276 ------------------------GGEI------------------------PGDTCDKYHEQLK 292

  Fly   336 AAALAREARHRKMVVVVLLMMAVFICLRLPAWVFLIMRLYGSYSEPIDW----LLYFSFGILNLF 396
            |        .||:|.::::::..|....||..::.|  |...|.:...|    .:|.:...|.:.
Human   293 A--------KRKVVKMMIIVVMTFAICWLPYHIYFI--LTAIYQQLNRWKYIQQVYLASFWLAMS 347

  Fly   397 SCALNPIFYTFLTQTIRTLTLVKHKIQGFLGCPPGKVPDGMPTDQMDKSGCCCGLRPPTFTWRCH 461
            |...|||.|..|.:..|    ...| :.|..||..||..   .|:::..           |.|.|
Human   348 STMYNPIIYCCLNKRFR----AGFK-RAFRWCPFIKVSS---YDELELK-----------TTRFH 393

  Fly   462 PSRDRAAATVIRDVDQPDPPSDQVQPDPSSLRRFLSYKQEVFT----IYKQCG--DSSSASIESS 520
            |:|..:..||.|      ..|..|..||:......|.:::..|    .:..|.  :|.|||..||
Human   394 PNRQSSMYTVTR------MESMTVVFDPNDADTTRSSRKKRATPRDPSFNGCSRRNSKSASATSS 452

  Fly   521  520
            Human   453  452

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG13575	NP_611903.1	7tm_1	67..>188	CDD:278431	32/122 (26%)
TACR3	NP_001050.1	7tmA_NKR_NK3R	86..367	CDD:320669	73/381 (19%)
		TM helix 1	87..113	CDD:320669	6/25 (24%)
		TM helix 2	120..146	CDD:320669	8/25 (32%)
		TM helix 3	158..188	CDD:320669	12/29 (41%)
		TM helix 4	199..220	CDD:320669	7/46 (15%)
		TM helix 5	244..273	CDD:320669	4/29 (14%)
		TM helix 6	292..322	CDD:320669	8/39 (21%)
		TM helix 7	335..360	CDD:320669	7/24 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	415..465		10/38 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4219
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900