DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG13575 and TACR1

DIOPT Version :9

Sequence 1:	NP_611903.1	Gene:	CG13575 / 37883	FlyBaseID:	FBgn0034996	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	NP_001049.1	Gene:	TACR1 / 6869	HGNCID:	11526	Length:	407	Species:	Homo sapiens

Alignment Length:	407	Identity:	82/407 - (20%)
Similarity:	146/407 - (35%)	Gaps:	122/407 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 SQLNRFKRHA-----FSAVVGTLFVLAFCGNLSTLY-VNSRRKLRPFFRACLISLACSDLVSSIF 101
            |:.|:|.:.|     ::|....:.|.:..||:..:: :.:.:::|......|::||.::...:.|
Human    20 SEPNQFVQPAWQIVLWAAAYTVIVVTSVVGNVVVMWIILAHKRMRTVTNYFLVNLAFAEASMAAF 84

  Fly   102 CTVSYMAQFQAQYLQLWTIGGFMCKFVPFITTTSVLSGSLTLVAIALDRYLAVMRPVLGFWSPDK 166
            .||   ..|.......|..|.|.|||..|....:|.:...::.|:|.|||:|::.|:      ..
Human    85 NTV---VNFTYAVHNEWYYGLFYCKFHNFFPIAAVFASIYSMTAVAFDRYMAIIHPL------QP 140

  Fly   167 RFSTLS----MLLIWACSIGSSGPLLGIYDYRKIYLLDVEDSSEES--EEVVTAV--PEELVVTE 223
            |.|..:    :.:||..::..:.| .|.|            |:.|:  ..||..:  ||......
Human   141 RLSATATKVVICVIWVLALLLAFP-QGYY------------STTETMPSRVVCMIEWPEHPNKIY 192

  Fly   224 LEMVHMCLAGDHDVGLYYVILFTLIFLPCIVSFLWLNAVIARQLWLRRHYHQEQQEQHQEPKEGQ 288
            .::.|:|:.         |:::   |||.:| ..:...|:...||............|::
Human   193 EKVYHICVT---------VLIY---FLPLLV-IGYAYTVVGITLWASEIPGDSSDRYHEQ----- 239

  Fly   289 FKTMANGGDLLMPSTLVSAMGVAVPFALDNTPLPPKSTVNAPGKKTTAAALAREARHRKMVVVVL 353
                            |||                                     .||:|.:::
Human   240 ----------------VSA-------------------------------------KRKVVKMMI 251

  Fly   354 LMMAVFICLRLPAWVFLIMRLYGSYSEPIDWL------LYFSFGILNLFSCALNPIFYTFLTQTI 412
            :::..|....||..:|.::    .|..|..:|      :|.:...|.:.|...|||.|..|....
Human   252 VVVCTFAICWLPFHIFFLL----PYINPDLYLKKFIQQVYLAIMWLAMSSTMYNPIIYCCLNDRF 312

  Fly   413 RTLTLVKHKIQGFLGCP 429
            |  ...||   .|..||
Human   313 R--LGFKH---AFRCCP 324

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13575	NP_611903.1	7tm_1	67..>188	CDD:278431	30/125 (24%)
TACR1	NP_001049.1	7tmA_NK1R	33..316	CDD:320668	73/381 (19%)
		TM helix 1	35..59	CDD:320668	4/23 (17%)
		TM helix 2	68..90	CDD:320668	6/24 (25%)
		TM helix 3	106..128	CDD:320668	5/21 (24%)
		TM helix 4	149..165	CDD:320668	3/16 (19%)
		TM helix 5	194..217	CDD:320668	7/35 (20%)
		TM helix 6	247..269	CDD:320668	5/21 (24%)
		TM helix 7	284..309	CDD:320668	7/24 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	364..407
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4219
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810