DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG13575 and tkr-2

DIOPT Version :9

Sequence 1:	NP_611903.1	Gene:	CG13575 / 37883	FlyBaseID:	FBgn0034996	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	NP_500930.1	Gene:	tkr-2 / 183595	WormBaseID:	WBGene00016761	Length:	391	Species:	Caenorhabditis elegans

Alignment Length:	440	Identity:	85/440 - (19%)
Similarity:	153/440 - (34%)	Gaps:	144/440 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 ALLHYTFDQLELYLEWAFAQHGE---ATPIPSIQPYPGVFVGDLSQLNRFKRHAFSAVVGTLFV- 62
            :|::.||   :.:.:..:..||.   ..|.|.:.|.       :||:       |..::.||.:
Worm    26 SLINCTF---QSFYDQMYQTHGVYFIFEPTPFVHPI-------VSQI-------FYGILFTLTIF 73

  Fly    63 LAFCGNLSTLY-VNSRRKLRPFFRACLISLACSDLVSSIFCT---VSYMAQFQAQYLQLWTIGGF 123
            ||..||.:.:: :...|::|......|.:||.:|...|:|.|   .||      .|..:|..|.|
Worm    74 LALMGNFTVMWIILYHRQMRSVTNYYLFNLAVADASISVFNTGFSWSY------NYYYVWKFGSF 132

  Fly   124 MCKFVPFITTTSVLSGSLTLVAIALDRYLAVMRPVLGFWSPDKRFSTLSMLLIWACSIGSSGPLL 188
            .|:....:..|.:.:...|::.::::||.|::.|:..  .|.:|.:...:::||..:.     |.
Worm   133 YCRINNLMGITPICASVFTMIVMSIERYYAIIHPLKK--RPGRRSTVTIIIMIWFMAF-----LF 190

  Fly   189 GIYDYRKIYLLDVEDSSEESEEVVTAVPEELVVTELEMVHMCLAGDHDVGLYYVILFTLIFLP-C 252
            |:..:                                     ||...|| .|:...:||...| |
Worm   191 GVPAF-------------------------------------LASKVDV-YYFYDGYTLYENPLC 217

  Fly   253 IVSFLWLNAVIARQLWLRRHYHQEQQEQHQEPKEGQFKTMANGG----DLLMPSTLVSA--MGVA 311
            :.                        :.:....|.....:.|.|    ..::|..::||  ..|.
Worm   218 LA------------------------DNYPGGNESLLGQVYNNGLITVQYILPLCILSAAYYRVG 258

  Fly   312 VPFALDNTPLPPKSTVNAPGKKTTAAALAREARHRKMVVV---VLLMMAVFICLRLPAW-----V 368
            |....|.|                    ..:.||.|.|..   ..:|:||.:.:.:..|     .
Worm   259 VELRKDKT--------------------VGDVRHAKSVAAKKKASIMLAVVVFIFMIVWFPYNAY 303

  Fly   369 FLIMRLYGSYSEPI-----DWLLYFSFGILNLFSCALNPIFYTFLTQTIR 413
            :|.:.|.    |||     ...:|.:...|.:.|...||:.|.|:.:..|
Worm   304 YLTLHLV----EPIGNKMLSLYIYINIYWLGMSSTVFNPVIYYFMNKRFR 349

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13575	NP_611903.1	7tm_1	67..>188	CDD:278431	28/124 (23%)
tkr-2	NP_500930.1	7tmA_TACR	62..352	CDD:320512	75/394 (19%)
		TM helix 1	64..88	CDD:320512	6/23 (26%)
		TM helix 2	97..119	CDD:320512	7/21 (33%)
		TM helix 3	135..157	CDD:320512	2/21 (10%)
		TM helix 4	178..194	CDD:320512	4/20 (20%)
		TM helix 5	232..255	CDD:320512	5/22 (23%)
		TM helix 6	280..305	CDD:320512	4/24 (17%)
		TM helix 7	320..345	CDD:320512	7/24 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4219
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24238
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.000