Protein Alignment nord and NDNF

DIOPT Version :9

• Sequence 1: NP_611900.1
• Gene: nord / 37882
• FlyBaseID: FBgn0050418
• Length: 587
• Species: Drosophila melanogaster
• Sequence 2: NP_078850.3
• Gene: NDNF / 79625
• HGNCID: 26256
• Length: 568
• Species: Homo sapiens
• Alignment Length: 613
• Identity: 137/613 - (22%)
• Similarity: 229/613 - (37%)
• Gaps: 163/613 - (26%)

  Fly    65 QKCPSL--QRYRKMLKD---FDD---LED-------LYVDVPVHIALAERQRKRFVLNLNDSTPL 114
            ||.|:.  :.::..::|   |.|   :.|       |:.|.|        :|..||:. .|:|||
Human    20 QKLPTRDEELFQMQIRDKAFFHDSSVIPDGAEISSYLFRDTP--------KRYFFVVE-EDNTPL 75

  Fly   115 TIRFS---APVGRKM--------------------------YYNQTGNPLRPAAVAPGPGVAVGS 150
            ::..:   ||:..|:                          ..|:.|..|     ....|..|..
Human    76 SVTVTPCDAPLEWKLSLQELPEDRSGEGSGDLEPLEQQKQQIINEEGTEL-----FSYKGNDVEY 135

  Fly   151 LVLPCALRGQYDLFVLARHSGA-LKVDALAEHPQHD--WPLLNATHRIAIRTQNRVRKREMIVKW 212
            .:...:..|.|.|.:|:..... .||.|... |:.|  :|.|....|:.:.:..|.   .:.:.|
Human   136 FISSSSPSGLYQLDLLSTEKDTHFKVYATTT-PESDQPYPELPYDPRVDVTSLGRT---TVTLAW 196

  Fly   213 ERS---KFDFHVMHYCLVIQ-------------RLSMDTPRMIFTNFCQAVSAYTDQQPMT---- 257
            :.|   ......:.||:||.             :||.|..      |..|.....|..|..
Human   197 KPSPTASLLKQPIQYCVVINKEHNFKSLCAVEAKLSADDA------FMMAPKPGLDFSPFDFAHF 255

  Fly   258 --PSCAAGGPLEGIWGAPPQ----RERRLNPRQNVHIVCTGKRRQQLLRRLLPRSSYHLDLFGIH 316
              ||..:|  .|..:.|.|.    |.....|:.::..:|.|.:....:..|.|.:.|:.|:|.:
Human   256 GFPSDNSG--KERSFQAKPSPKLGRHVYSRPKVDIQKICIGNKNIFTVSDLKPDTQYYFDVFVV- 317

  Fly   317 QGRQNLTLRLASSQV-NFNRTQPLALKQQALMQLKIG-------GQHGKQVYSFKVPQTTRQLGE 373
                |:...::::.| .|.||:..|  :|..::||.|       .:.|.:...| .|.::.|...
Human   318 ----NINSNMSTAYVGTFARTKEEA--KQKTVELKDGKITDVFVKRKGAKFLRF-APVSSHQKVT 375

  Fly   374 PFMRHLLIPCSGSEIRV----KLLRQRSEVGKTEAFYSPTYIRQKGVLPGERYLMRFEPSNDDEA 434
            .|:...|   ...:|:|    |||..::..| .:.|    .:|.|   |..:||:|.:.:...
Human   376 FFIHSCL---DAVQIQVRRDGKLLLSQNVEG-IQQF----QLRGK---PKAKYLVRLKGNKKG-- 427

  Fly   435 LRAQKVMVALSSEALFRDLPELPQNTTV--FNVRTRCSRATIAWNGSPDERELSYCIIV------ 491
              |..:.:..::....:..|.||::|.:  |:....||.||:||.|:.:..:  :||..
Human   428 --ASMLKILATTRPTKQSFPSLPEDTRIKAFDKLRTCSSATVAWLGTQERNK--FCIYKKEVDDN 488

  Fly   492 FNLPQRNRSVVDFTNYCM--DFVPKRVMQYRYFEWMTCR--ERQQSPDNIETETILNLMPGSSYL 552
            :|..|:.|.    .|.|:  |...|.       |.:.|:  ..|.....:.||||..|.||.|||
Human   489 YNEDQKKRE----QNQCLGPDIRKKS-------EKVLCKYFHSQNLQKAVTTETIKGLQPGKSYL 542

  Fly   553 --VYVTANLSMGKPLPYQALTLHMASQC 578
              |||..:  .|..:.||:..:.....|
Human   543 LDVYVIGH--GGHSVKYQSKVVKTRKFC 568

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nord	NP_611900.1	DUF2369	286..578	CDD:287188	77/317 (24%)
NDNF	NP_078850.3	DUF2369	291..383	CDD:313417	23/102 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147909
Domainoid	1	1.000	45	1.000	Domainoid score	I12271
eggNOG	1	0.900	-	-		E1_KOG4806
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	50	1.000	Inparanoid score	I5478
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D152874at33208
OrthoFinder	1	1.000	-	-		FOG0004105
OrthoInspector	1	1.000	-	-		oto89293
orthoMCL	1	0.900	-	-		OOG6_109866
Panther	1	1.100	-	-	O	PTHR14619
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4268
SonicParanoid	1	1.000	-	-		X5574
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.790