Protein Alignment Ir60a and grik5

DIOPT Version :10

• Sequence 1: NP_611901.1
• Gene: Ir60a / 37881
• FlyBaseID: FBgn0034994
• Length: 716
• Species: Drosophila melanogaster
• Sequence 2: NP_001315085.1
• Gene: grik5 / 798791
• ZFINID: ZDB-GENE-070821-6
• Length: 1067
• Species: Danio rerio
• Alignment Length: 788
• Identity: 148/788 - (18%)
• Similarity: 268/788 - (34%)
• Gaps: 221/788 - (28%)

  Fly    27 LSNETANTVIFMLPE--------KDLGPDVWKAGVGCLDSFAQIFFFRNPKERFTRAYNLMLVHA 83
            :|.||.:  |.||.:        |::..|  |.....:|:.|.|.:.     ...:|..|.:..|
Zfish   196 ISRETLS--IRMLDDNLDPTPLLKEIRDD--KIATIIIDANASISYL-----ILKKASELGMTSA 251

  Fly    84 FH------LSSP---ADQIQEGFSKLINEAVTNPGPPDREELFQ-----MRVASDYNITNGTEDK 134
            |:      :..|   .|.|.:..|.::..::.|...|...|..:     .|...|.|...|.. .
Zfish   252 FYKYILTTMDFPLLWLDDIVDEQSNIVGFSMFNTTHPFYLEFIRSLNLSWREGCDINPYPGPA-L 315

  Fly   135 GELILADNYVIVVDSVDRLKELMKKKIVEMRSWNPGARFLVLFHNATCRNRPLGVAS-NIFKDLM 198
            ...:|.|...:||.:|..|.          ||...|.             :||...| .|::
Zfish   316 SSALLFDAVHVVVSAVQELN----------RSQEIGV-------------KPLSCTSPQIWQ--- 354

  Fly   199 EMFYVHRVALLYANSTMNYNLLVNDY--------------YSNVNCRILNVQSVGQCHDGKLYPN 249
                       :..|.|||..:| :|              .:|....||.....|....|..|.|
Zfish   355 -----------HGTSLMNYLRMV-EYDGLTGRVEFNSKGQRTNYTLHILEKHRGGHKEIGIWYSN 407

  Fly   250 NAVVKASMQ-DYVSGFSPRNCTFFACSSISAPFV---------------EADCILGLEMRILGFM 298
            |.::..|.. |.....:..|.:....:.:..|:|               |..|:     .:|..:
Zfish   408 NTLLMNSTSLDINVSETLANKSLIITTILENPYVMRKINYQEFEGNEQYEGFCV-----DMLREL 467

  Fly   299 KNRLKFDVNQTCSLESRGEMDGP---ANWTGLLGKVQNNECDFVFGGYYPDNE---VADHFWGSD 357
            .:.|||  .....|...|....|   .:|||::|::.|.:.|.....:...:|   |.|.   |.
Zfish   468 SDILKF--TYRIKLVDDGLYGAPEPNGSWTGMVGELINRKADLAVAAFTITSEREKVIDF---SK 527

  Fly   358 TYLQ-DAHTWYIKMADRRPAWQALVGIFEAYTWIGFILI--LIISWLF----------WFTLVMI 409
            .::. .....|.....|:|.:.:.:..|....|: |:|:  |.:|.:.          |:.....
Zfish   528 PFMTLGISILYRVHIGRKPGYFSFLDPFSPAVWL-FMLLAYLAVSCVLFLSARLSPYEWYNPHPC 591

  Fly   410 LPEPKYYQQLSLTAINALAVTISIAVQE----RPICETTRLFFMALTLYGLNVVATYTSKMIA-- 468
            |.|.:...:...|..|:|...:...:|:    .|...:||........:.|.::::||:.:.|
Zfish   592 LRERRDLLENQYTLGNSLWFPVGGFMQQGSEIMPRALSTRCVSGVWWAFTLIIISSYTANLAAFL 656

  Fly   469 ---TFQDPGYLHQLDELTEV--VAAGIPFGGHEESRDWFEND-----DDMWIFNGYNISPEFIPQ 523
               ..:.|  :...|:|.:.  :..|...||  .:..:|.|.     ..||.:. |:..|....:
Zfish   657 TVQRMEVP--IESPDDLADQTNIQYGTIHGG--STMTFFMNSRYQTYQRMWNYM-YSKQPSVFVK 716

  Fly   524 SKNLEAVKWGQRCILSNRMYTMQSPLADVIYAFPNNVF-------SSPVQMIMKAGFPFLFEMN- 580
            |.. |.:   .|.:.|...:.::|.:.:...:...|:.       :....:.|..|.||..|::
Zfish   717 STE-EGI---ARVVNSKYAFLLESTMNEYHRSLNCNLTQIGGLLDTKGYGIGMPLGSPFRDELSL 777

  Fly   581 SIIRLMRDVGIFQKIDADFRYNNTYLNRINKMRPQFPE----------TAIVLTTEHLKGPFFIL 635
            ::::|..:                  ||:..::.::.|          .|..|..|::.|.|.:|
Zfish   778 AVLQLQEN------------------NRLEILKRRWWEGGKCPKEEDHRAKGLGMENIGGIFVVL 824

  Fly   636 VVGSCWAALTFIGELIIHRWRTQLVSTSEQQ-----DRR---------------------SDKRR 674
            :.|...|....:.|.:   |.|:..:.:::.     ||:                     |.|:.
Zfish   825 ICGLIIAVFVAVMEFV---WSTRRSAETDEVRPLSCDRQYHSHTTVSVCQEMLTEFRNAVSCKKS 886

  Fly   675 RRRRRRKP 682
            .|.|||:|
Zfish   887 SRLRRRRP 894

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir60a	NP_611901.1	None
grik5	NP_001315085.1	PBP1_iGluR_Kainate_KA1_2	36..414	CDD:380616	54/265 (20%)
		Periplasmic_Binding_Protein_Type_2	427..797	CDD:473866	71/407 (17%)