Protein Alignment Ir60a and Grid2

DIOPT Version :10

• Sequence 1: NP_611901.1
• Gene: Ir60a / 37881
• FlyBaseID: FBgn0034994
• Length: 716
• Species: Drosophila melanogaster
• Sequence 2: NP_077355.2
• Gene: Grid2 / 79220
• RGDID: 68368
• Length: 1007
• Species: Rattus norvegicus
• Alignment Length: 547
• Identity: 103/547 - (18%)
• Similarity: 200/547 - (36%)
• Gaps: 139/547 - (25%)

  Fly   212 NSTMNYNLLVNDYYSNVNCRILNVQSVGQCHDGKLYPNNAVVKASMQDYVSGFSPRNCTFFACSS 276
            |..:::.:|..:|...:.   ..|:.:| |.:.....|.::....:::.:.|...|..|.
  Rat   393 NPNVHFEILGTNYGEELG---RGVRKLG-CWNPVTGLNGSLTDKKLENNMRGVVLRVVTV----- 448

  Fly   277 ISAPFV-EADCILGLEMRILGF-------MKNRLKFDVNQTCSLESR-GEMDGPANWTGLLGKVQ 332
            :..||| .::.:||...:..||       :.|.|.|:.....:.:.: |.......|.||:|::.
  Rat   449 LEEPFVMVSENVLGKPKKYQGFSIDVLDALSNYLGFNYEIYVAPDHKYGSPQEDGTWNGLVGELV 513

  Fly   333 NNECDFVFGG--YYPDNEVADHFWGSDTYLQDAHTWYIKMADRRPAWQALVGIFEAYTW------ 389
            ....|.....  ..||.|....|  :..|:..:....::.|::.....|.:..|:...|
  Rat   514 FKRADIGISALTITPDRENVVDF--TTRYMDYSVGVLLRRAEKTVDMFACLAPFDLSLWACIAGT 576

  Fly   390 ---IGFILILIISWLFWFTLVMILPEPKYYQQLSLTA---INALAVTISIAVQ---ERPICE-TT 444
               :| :|:.:::||          .|...|..|:|:   .|::.......||   |.|... .|
  Rat   577 VLLVG-LLVYLLNWL----------NPPRLQMGSMTSTTLYNSMWFVYGSFVQQGGEVPYTTLAT 630

  Fly   445 RLFFMALTLYGLNVVATYTSKMIATF---QDPGYLHQLDELTEVVAAGIPFGGHEESRDW----- 501
            |:...|..|:.|.|:::||:.:.|..   :....:..|.:|::  ...||:|...:|..:
  Rat   631 RMMMGAWWLFALIVISSYTANLAAFLTITRIESSIQSLQDLSK--QTDIPYGTVLDSAVYQHVRM 693

  Fly   502 -----FEND---DDMW-IFNGYNISPEFIPQSK-NLEAVKWGQRCILSN--------------RM 542
                 ||.|   ..|| :.|..|.|...:.:|: .::.||:|....:.:              ..
  Rat   694 KGLNPFERDSMYSQMWRMINRSNGSENNVLESQAGIQKVKYGNYAFVWDAAVLEYVAINDPDCSF 758

  Fly   543 YTMQSPLADVIYAFP-------NNVFSSPVQMIMKAGFPFLFEMNSIIRLMR--------DVGIF 592
            ||:.:.:||..|...       .:|||..:..:.::|     :|:    :::        ...::
  Rat   759 YTVGNTVADRGYGIALQHGSPYRDVFSQRILELQQSG-----DMD----ILKHKWWPKNGQCDLY 814

  Fly   593 QKIDADFRYNNTYLNRINKMRPQFPETAIVLTTEHLKGPFFILVVG---SCWAALTFIGELIIHR 654
            ..:||                   .:....|..:.|.|.|.||..|   ||..|       ::..
  Rat   815 SSVDA-------------------KQKGGALDIKSLAGVFCILAAGIVLSCLIA-------VLET 853

  Fly   655 WRTQLVST---SEQQDRRSDKRRRRRR 678
            |.::...:   |::.|:..|.....||
  Rat   854 WWSRRKGSRVPSKEDDKEIDLEHLHRR 880

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir60a	NP_611901.1	None
Grid2	NP_077355.2	Interaction with CBLN1 homotrimer. /evidence=ECO:0000250|UniProtKB:O43424	24..345
		Periplasmic_Binding_Protein_type1	28..429	CDD:471960	7/39 (18%)
		PBP2_iGluR_delta_2	440..806	CDD:270449	78/394 (20%)
		Interaction with AP4M1. /evidence=ECO:0000269|PubMed:14572453	921..991
		PDZ-binding. /evidence=ECO:0000250	1005..1007