Protein Alignment Ir60a and Grid1

DIOPT Version :10

• Sequence 1: NP_611901.1
• Gene: Ir60a / 37881
• FlyBaseID: FBgn0034994
• Length: 716
• Species: Drosophila melanogaster
• Sequence 2: NP_077354.1
• Gene: Grid1 / 79219
• RGDID: 68366
• Length: 1009
• Species: Rattus norvegicus
• Alignment Length: 763
• Identity: 146/763 - (19%)
• Similarity: 248/763 - (32%)
• Gaps: 215/763 - (28%)

  Fly    44 LGPDVWKAGVGCLDSFAQIF--FFRNPKERFTRAYNLMLVHAFHLSSPADQIQEGFSKLINEAV- 105
            ||.||....|.  .:.:.:|  .|...|......|...|..|..|.||     :|....|||||
  Rat   188 LGLDVSLQKVD--KNISHVFTSLFTTMKTEELNRYRDTLRRAILLLSP-----QGAHSFINEAVE 245

  Fly   106 TNPGPPDREELFQMRVASDYNITN-----------------GTED-------------------K 134
            ||....|...:|.....||..|.:                 ..:|                   :
  Rat   246 TNLASKDSHWVFVNEEISDPEILDLVHSALGRMTVVRQIFPSAKDNQKCMRNNHRISSLLCDPQE 310

  Fly   135 GEL-ILADNYVIVVDSVDRLKELMKKKIVEMRSWNPGARFLVLFHNATCRNRPLGVASNIFKDLM 198
            |.| :|..:.:.:.|||..|.....:|: |.|.|:..|....:..:....|....:...|.|.
  Rat   311 GYLQMLQISNLYLYDSVLMLANAFHRKL-EDRKWHSMASLNCIRKSTKPWNGGRSMLDTIKKG-- 372

  Fly   199 EMFYVHRVALL--------YANSTMNYNLLVNDYYSNVNCRILNVQSVGQCHDGKLYPNNAVVKA 255
                 |...|.        .:|..:.:.:|...|.......:..:.:         :.:...:..
  Rat   373 -----HITGLTGVMEFREDSSNPYVQFEILGTTYSETFGKDMRKLAT---------WDSEKGLNG 423

  Fly   256 SMQDYVSGFSPRNCTFFACSSISAPFV-EADCILGLEMRILGFMKNRL---------KFDVNQTC 310
            |:|:...|...:..|....:.:..||| .|:.|||...|..||..:.|         |:::.|
  Rat   424 SLQERPMGSRLQGLTLKVVTVLEEPFVMVAENILGQPKRYKGFSIDVLDALAKALGFKYEIYQ-- 486

  Fly   311 SLESR-GEMDGPANWTGLLGKVQNNECDFVFGG--YYPDNEVADHFWGSDTYLQDAHTWYIKMAD 372
            :.:.| |......:|.|::|::.:...|.....  ..|:.|....|  |..|:..:....||..:
  Rat   487 APDGRYGHQLHNTSWNGMIGELISKRADLAISAITITPERESVVDF--SKRYMDYSVGILIKKPE 549

  Fly   373 RRPAWQALVGIFEAYTWIGFILILIISWLFWFTLVMI---------LPEPK-------------- 414
            .:.:..:|...|:...|......:.:..:..|.|..|         .|.|.
  Rat   550 EKISIFSLFAPFDFAVWACIAAAIPVVGVLIFVLNRIQAVRSQSATQPRPSASATLHSAIWIVYG 614

  Fly   415 -YYQQLSLTAINALAVTISIAVQERPICETTRLFFMALTLYGLNVVATYTSKMIA---------- 468
             :.||...:::|::|:               |:...:..|:.|.|.::||:.:.|
  Rat   615 AFVQQGGESSVNSVAM---------------RIVMGSWWLFTLIVCSSYTANLAAFLTVSRMDSP 664

  Fly   469 --TFQDPGYLHQLDELTEVVAAGIPFGGHEESR--DWF--------ENDD---DMWIFNGYN--- 515
              ||||      |.:..|     :.:|...:|.  ::|        |.|.   ::|.....|
  Rat   665 VRTFQD------LSKQLE-----MSYGTVRDSAVYEYFRAKGTNPLEQDSTFAELWRTISKNGGA 718

  Fly   516 ----ISPEFIPQSKNLEAVKWGQRCILSNRMYTMQSPLAD---VIYAFPNNVFSSPVQMIMKAGF 573
                .:|     |:.:...|.|....|.:......:.|.|   .:....|::.|....:.::.|.
  Rat   719 DNCVSNP-----SEGIRKAKKGNYAFLWDVAVVEYAALTDDDCSVTVIGNSISSKGYGIALQHGS 778

  Fly   574 PFLFEMNSIIRLMRDVGIFQKIDADFRYNNTYLNRINKMRPQFPETAIVLTTEH---------LK 629
            |:....:..|..::|.|     |.|          :.|.: .:|.|.....|.|         ||
  Rat   779 PYRDLFSQRILELQDTG-----DLD----------VLKQK-WWPHTGRCDLTSHSSAQTDGKSLK 827

  Fly   630 -----GPFFILVVGSCWAALTFIGELIIHRWRTQLVSTSEQQDRRSDK 672
                 |.|.||.:|...|.|....||   .|.:   :...|:..:.||
  Rat   828 LHSFAGVFCILAIGLLLACLVAALEL---WWNS---NRCHQETPKEDK 869

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir60a	NP_611901.1	None
Grid1	NP_077354.1	Interaction with CBLN1. /evidence=ECO:0000250|UniProtKB:Q61627	21..436		51/271 (19%)
		PBP1_iGluR_delta_1	25..425	CDD:380615	48/260 (18%)
		PBP2_iGluR_delta_1	436..806	CDD:270448	76/420 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	931..960