DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir60a and grin2ab

DIOPT Version :9

Sequence 1:	NP_611901.1	Gene:	Ir60a / 37881	FlyBaseID:	FBgn0034994	Length:	716	Species:	Drosophila melanogaster
Sequence 2:	XP_009304490.1	Gene:	grin2ab / 570493	ZFINID:	ZDB-GENE-070424-223	Length:	1445	Species:	Danio rerio

Alignment Length:	437	Identity:	73/437 - (16%)
Similarity:	157/437 - (35%)	Gaps:	101/437 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   286 CILGLEMRILGFMKNRLKFDVNQTCSLESRGEMDGPAN--WTGLLGKVQNNECDFVFGGYYPDNE 348
            |..|..:.||..:...:||..:  ..|.:.|:.....|  |.|::|:|...:.....|....:.|
Zfish   443 CCKGFCIDILKKIARNVKFTYD--LYLVTNGKHGKKINNVWNGMVGEVVYKKAVMAVGSLTINEE 505

  Fly   349 VADHFWGSDTYLQDAHTWYIKMADRRPAWQALVGIFEAYTWI-GFILILIISWLFWFTLVMILP- 411
            .::....|..:::...:..:..::...:..|.:..|.|..|: .|:::||::.:..|....|.|
Zfish   506 RSEAIDFSVPFVETGISVMVSRSNGTVSPSAFLEPFSASVWVMMFVMLLIVTAIAVFLFEFISPL 570

  Fly   412 -------------EPKYYQQLSLTAINALAVTISIAVQERPICETTRLFFMALTLYGLNVVATYT 463
                         .|.:....::..:..|....|:.|| .|...|::........:.:..:|:||
Zfish   571 GFNRNLAQGKDPHGPSFTIGKAVWLLWGLVFNNSVPVQ-NPRGTTSKFIVSVWAFFAVIFLASYT 634

  Fly   464 SKMIATFQDPGYLHQLDELTEVVAAGIPFGGHEESRDWFENDDDMWIFNGYNISPEF----IPQS 524
            :.:.|......::.|:..|:                       |....:.|:.||.|    :|..
Zfish   635 ANLAAFMIQEEFVDQVTGLS-----------------------DRKFQSPYSYSPPFRFGTVPNG 676

  Fly   525 -------KNLEA-----VKWGQRCILSNRMYTMQSPLADVIYAFPNNVFSSPVQMIM-------- 569
                   ||..|     ||:.|..:: :.:.::::...|   ||   ::.:.|...|
Zfish   677 STERNIRKNYPAMHQYMVKYHQTGVV-DALVSLKTGKLD---AF---IYDAAVLNYMAGRDDGCK 734

  Fly   570 -----------KAGFPFLFEMNSIIRLMRDVGI--------FQKIDADFRYNNTYLNRINKMRPQ 615
                       ..|:....:..|..:.:.|:.|        .::::|.:.....:..:...|..|
Zfish   735 LVTIGSGYIFATTGYGIAMQKGSYWKRLVDLAILGIIGDGEMEELEAQWLTGICHNEKNEVMSSQ 799

  Fly   616 FPETAIVLTTEHLKGPFFILVVGSCWAALTFIGELIIHRWRTQLVST 662
                   |..:::.|.|::|......:.:||:.|.:.: ||.:...|
Zfish   800 -------LDVDNMAGVFYMLAAAMALSLITFVWEHLFY-WRLRYCFT 838

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir60a	NP_611901.1	None
grin2ab	XP_009304490.1	PBP1_iGluR_NMDA_NR2	25..382	CDD:107373
		ANF_receptor	48..358	CDD:279440
		PBP2_iGluR_NMDA_Nr2	393..790	CDD:270436	61/379 (16%)
		Lig_chan	544..816	CDD:278489	48/309 (16%)
		NMDAR2_C	827..1445	CDD:287527	3/13 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591447
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.930