DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir60a and grin3ba

DIOPT Version :9

Sequence 1:	NP_611901.1	Gene:	Ir60a / 37881	FlyBaseID:	FBgn0034994	Length:	716	Species:	Drosophila melanogaster
Sequence 2:	XP_021323058.1	Gene:	grin3ba / 566411	ZFINID:	ZDB-GENE-070912-354	Length:	1118	Species:	Danio rerio

Alignment Length:	531	Identity:	111/531 - (20%)
Similarity:	182/531 - (34%)	Gaps:	138/531 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   235 VQSVGQCHDGKL----YPNNAVVK----ASMQDYVSGFSP---RNCTFFACSSISAPFVEADCIL 288
            |...|||..|:|    ..||:.|.    ..::...|...|   |.|.:..|..:.....| |...
Zfish   474 VDEEGQCPAGQLCLDPQTNNSEVLNQLFRELEQTNSSSLPTDMRKCCYGYCIDLLEKLAE-DMHF 537

  Fly   289 GLEMRILGFMKNRLKFDVNQTCSLESRGEMDGPANWTGLLGKVQNNECDFVFGGYYPDN------ 347
            ..::.|:|..|               .|...| ..|:||:|.:.:...|.....:..::
Zfish   538 EFDLYIVGDGK---------------YGAWKG-GRWSGLVGDLLSGVADMAVTSFSINSARSRVI 586

  Fly   348 EVADHFWGS---------DTYLQ-DAHTWYIKMADRRPAWQALVGIFEAYTWIGFILILIISWLF 402
            :....|:.:         ||... .|..|.:.       |...||||.|.    .|..|.|:...
Zfish   587 DFTSPFFSTSLGILVRSKDTAAPIGAFMWPLH-------WSMWVGIFVAL----HITALFITLYE 640

  Fly   403 WFTLVMILPEPK-------YYQQLSLTAINALAVTISIAVQERPICETTRLFFMALTLYGLNVVA 460
            |.:...:.|..:       |...|:|........|::   .:.|.|.|.|.......::.|.|::
Zfish   641 WNSPFGMTPHGRNRIRVFSYSSALNLCYAILFGRTVA---SKTPKCWTGRFLMNLWAIFCLLVLS 702

  Fly   461 TYTSKMIA------TFQDPGYLHQLDELTEVVAAGIPFGGHEES-------RDWFENDDDMWIFN 512
            :||:.:.|      ||::...:|  |......:.|..||...||       :.:.|..:.|..||
Zfish   703 SYTANLAAVMVGEKTFEEVSGIH--DVKLHHPSLGFRFGTVRESSAEDYVKKSFPEMHEYMRRFN 765

  Fly   513 GYNISPEFIPQSK----NLEAVKWGQRCILSNRMYTMQSPLADVIYAFPNNVFSSPVQMIMKAGF 573
             ...:|:.:...|    .|:|             :.|...|.|...:...:.      .::..|.
Zfish   766 -KPTTPDGVSTLKTDPPQLDA-------------FIMDKALLDYEVSIDADC------KLLTVGK 810

  Fly   574 PFLFE-------MNSIIRLMRDVGIFQKIDADFRY-NNTYLNRIN----KMRPQFPETAIVLTT- 625
            ||..|       .||  .|.|:|..:..     || ::.|::.::    |:.|.......|..|
Zfish   811 PFAIEGYGIGLPQNS--PLTRNVSEYVS-----RYKSDGYMDMLHDKWYKVVPCGKRVFAVTETL 868

  Fly   626 ----EHLKGPFFILVVGSCWAALTFIGE-----LIIHRWRTQ-----LVSTSEQQDRRSDKRRRR 676
                :|..|.|.:|.||...|.||.:||     .|:...|.|     .:.||::..|..:.....
Zfish   869 QMGIQHFSGLFVLLCVGVAGALLTLLGEHAFFRFILPHLRHQQRFKYWLHTSQKIHRAINMGCDD 933

  Fly   677 RRRRKPEKDNR 687
            .|:.:.|..:|
Zfish   934 ERKSEAESSDR 944

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir60a	NP_611901.1	None
grin3ba	XP_021323058.1	Periplasmic_Binding_Protein_Type_1	26..428	CDD:324556
grin3ba	XP_021323058.1	PBP2_iGluR_NMDA_Nr3	457..852	CDD:270438	87/437 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591627
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.830