DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir60a and grin3a

DIOPT Version :9

Sequence 1:	NP_611901.1	Gene:	Ir60a / 37881	FlyBaseID:	FBgn0034994	Length:	716	Species:	Drosophila melanogaster
Sequence 2:	XP_009303361.1	Gene:	grin3a / 564832	ZFINID:	ZDB-GENE-130530-780	Length:	1111	Species:	Danio rerio

Alignment Length:	558	Identity:	113/558 - (20%)
Similarity:	194/558 - (34%)	Gaps:	138/558 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   234 NVQSVGQCHDGKL----YPNNAVVKASMQDYVSGFSPRNCTFFACSSISAPFVEADCILGLEMRI 294
            :|...|.|..|:|    ..|:.   |.::....|....|.|        .|.....|..|..:.:
Zfish   536 DVDDEGLCPAGQLCLDPLTNDT---ALLESLFQGLQGANDT--------VPLEFKKCCYGYCIDL 589

  Fly   295 LGFMKNRLKFDVNQTCSLESRGEMDGPAN--WTGLLGKVQNNECDFVFGGYYPDNEVADHFWGSD 357
            |..:...:.||.:  ..:...|:.....|  ||||:|       |.:.|        |.|...:.
Zfish   590 LEKLAEDMGFDFD--LYIVGDGKYGAYKNGRWTGLVG-------DLMSG--------AAHLAVTS 637

  Fly   358 TYLQDAHTWYIKMADRRPAWQALVGI----------FEAY-------TWIGFILILIISWLF--- 402
            ..:..|.:..|....  |.:...:||          ..|:       .|:|..:.|.::.:|
Zfish   638 FSINSARSQVIDFTS--PFFSTSLGILVRTRDTAAPIGAFMWPLHWSMWLGIFVSLHVTAVFLTL 700

  Fly   403 --WFTLVMILPEPKYYQQLSLTAINALAVTISI-----AVQERPICETTRLFFMALTLYGLNVVA 460
              |.:...:.|..:...:: .:..:||.|..:|     |..:.|.|.|.|.......::.|..::
Zfish   701 YEWKSPFGMTPRGRNRDRV-FSFSSALNVCYAILFGRTAAIKPPKCWTGRFLMNLWAIFCLFCLS 764

  Fly   461 TYTSKMIA------TFQDPGYLHQLDELTEVVAAGIPFGGHEES-------RDWFENDDDMWIFN 512
            |||:.:.|      |::....:|  |......:.|..||...||       :.:.|..:.|..:|
Zfish   765 TYTANLAAVMVGEKTYEQLSGIH--DPKLHHPSQGFRFGTVRESSAEDYVKKSFPEMHEYMRRYN 827

  Fly   513 GYNISPEFIPQSKN----LEAVKWGQRCILSNRMYTMQSPLADVIYAFPNNVFSSPVQMIMKAGF 573
            . ..:|:.|...|:    |:|             :.|...|.| .:|..:..:.|    ::..|:
Zfish   828 A-PTTPDGIDHLKDDPQKLDA-------------FIMDKALLD-YWAHADKXYIS----LLLTGY 873

  Fly   574 --------PFLFEMNSIIRLMRDVGIFQKIDADFRYNNTYLNRINKMRPQFPETAIVLTT----- 625
                    |....::.::...:..|..     |..::..|     |:.|....:..|..|
Zfish   874 GIGLKQNSPLTSNISELVSQYKSDGFM-----DMLHDKWY-----KVVPCGKRSFAVTETLQMGI 928

  Fly   626 EHLKGPFFILVVGSCWAALTFIGELIIHRW---RTQ-------LVSTSEQQDRRSD---KRRRRR 677
            :|..|.|.:|.||...:.||.:||.|:|||   |.|       .:.||::..|..:   |..:.:
Zfish   929 KHFSGLFVMLCVGVALSLLTTLGEHIVHRWVIPRMQESTEHKYWLHTSQRLHRALNPTFKEDKLQ 993

  Fly   678 RRRKPEKDNRWQRQVQVAPVVRFTPVKRRKVFQGQTSQ 715
            ...||||........|:......||...|:....|..|
Zfish   994 TVAKPEKSCNVGNNQQMPWNSLGTPNCNRRKLSNQEGQ 1031

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir60a	NP_611901.1	None
grin3a	XP_009303361.1	Periplasmic_Binding_Protein_Type_1	36..502	CDD:299141
		ANF_receptor	132..452	CDD:279440
		PBP2_iGluR_NMDA_Nr3	518..908	CDD:270438	78/428 (18%)
		Lig_chan	682..941	CDD:278489	54/290 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591628
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.830