DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir60a and grin2aa

DIOPT Version :9

Sequence 1:	NP_611901.1	Gene:	Ir60a / 37881	FlyBaseID:	FBgn0034994	Length:	716	Species:	Drosophila melanogaster
Sequence 2:	XP_021329529.1	Gene:	grin2aa / 563297	ZFINID:	ZDB-GENE-070424-129	Length:	1460	Species:	Danio rerio

Alignment Length:	438	Identity:	72/438 - (16%)
Similarity:	160/438 - (36%)	Gaps:	103/438 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   286 CILGLEMRILGFMKNRLKFDVNQTCSLESRGEMDGPAN--WTGLLGKVQNNECDFVFGGYYPDNE 348
            |..|..:.||..:...:||..:  ..|.:.|:.....|  |.|::|:|.|.:.....|....:.|
Zfish   452 CCKGFCIDILKKIARNVKFTYD--LYLVTNGKHGKKINNVWNGMVGEVVNKKAVMAVGSLTINEE 514

  Fly   349 VADHFWGSDTYLQDAHTWYIKMADRRPAWQALVGIFEAYTWI-GFILILIISWLFWFTLVMILP- 411
            .::....|..:::...:..:..::...:..|.:..|.|..|: .|:::|:::.:..|....|.|
Zfish   515 RSEVIDFSVPFVETGISVMVSRSNGTVSPSAFLEPFSASVWVMMFVMLLLVTAMAVFMFEYISPL 579

  Fly   412 -------------EPKYYQQLSLTAINALAVTISIAVQERPICETTRLFFMALTLYGLNVVATYT 463
                         .|.:....::..:..|....|:.|| .|...|::........:.:..:|:||
Zfish   580 GFNRNLAQGKDPHGPSFTMGKAVWLLWGLVFNNSVPVQ-NPKGTTSKFIVSVWAFFAVIFLASYT 643

  Fly   464 SKMIATFQDPGYLHQLDELTEVVAAGIPFGGHEESRDWFENDDDMWIFNGYNISPEF----IPQ- 523
            :.:.|......::.|:..|:                       |....:.|:.||.|    :|.
Zfish   644 ANLAAFMIQEEFVDQVTGLS-----------------------DKKFQSPYSYSPPFRFGTVPNG 685

  Fly   524 --SKNLE---------AVKWGQRCILSNRMYTMQSPLADVIYAFPNNVFSSPVQMIMKA------ 571
              .:|:.         .||:.|..: ::.:.::::...|   ||   ::.:.|...|..
Zfish   686 STERNIRKNYPDMHQYMVKYHQTGV-NDALVSLKTGKLD---AF---IYDAAVLNYMAGRDEGCK 743

  Fly   572 ----GFPFLFEMN------------------SIIRLMRDVGIFQKIDADFRYNNTYLNRINKMRP 614
                |..::|...                  :|:.::.| |..::::|.:.....:..:...|..
Zfish   744 LVTIGSGYIFATTGYGIALQKGSLWKRPVDLAILAIIGD-GEMEELEAQWLTGICHNEKNEVMSS 807

  Fly   615 QFPETAIVLTTEHLKGPFFILVVGSCWAALTFIGELIIHRWRTQLVST 662
            |       |..:::.|.|::|......:.:||:.|.:.: ||.:...|
Zfish   808 Q-------LDVDNMAGVFYMLATAMGLSLITFVWEHLFY-WRLRYCFT 847

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir60a	NP_611901.1	None
grin2aa	XP_021329529.1	PBP1_iGluR_NMDA_NR2	33..389	CDD:107373
		PBP2_iGluR_NMDA_Nr2	400..799	CDD:270436	60/380 (16%)
		NMDAR2_C	836..1460	CDD:313729	3/13 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591445
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.830