DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir60a and grik1b

DIOPT Version :9

Sequence 1:	NP_611901.1	Gene:	Ir60a / 37881	FlyBaseID:	FBgn0034994	Length:	716	Species:	Drosophila melanogaster
Sequence 2:	XP_690040.5	Gene:	grik1b / 561540	ZFINID:	ZDB-GENE-070821-1	Length:	906	Species:	Danio rerio

Alignment Length:	753	Identity:	119/753 - (15%)
Similarity:	226/753 - (30%)	Gaps:	249/753 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 IVNLSNETANTVIFMLPEKDLGPDVWKAGVGCLDSFAQIFF-----FRNPKERFT-RAYNLMLVH 82
            |.:.|.:||..|:..|           ..:|.:..:...||     :....|.|. ...|:....
Zfish   255 IFDCSYQTAADVLKQL-----------LSMGMMTEYYHFFFTTLDLYSLDLEPFRYSGVNMTGFR 308

  Fly    83 AFHLSSPADQIQEGFSKLINEAVTNPGPPDREELFQMRVASDYNITNGTEDKGELILADNYVIVV 147
            ..::.:|  |:.....|...|.:..|..|:.            .:.:|.......::.|...:|.
Zfish   309 LLNIDNP--QVASVVEKWSMERLQAPPKPET------------GLQDGMMTTEAALMYDAVYMVA 359

  Fly   148 DSVDRLKELMKKKIV--EMRSWNPGARFLVLFHNATCR--------NRPLGVASNIFKDLMEM-- 200
            .:..|..::....:.  ..:.|..|:||:.:|..|...        |:..|:..:...|::.:
Zfish   360 AASQRASQITVSSLQCHRHKPWRFGSRFISMFKEAQWNGLTGQIIINKTDGLRKDFDLDIISLKE 424

  Fly   201 --------------------FYVHRVALLYANSTMNYNLLVNDYYSNVNCRILNVQSVGQCHDGK 245
                                .:.....|...:|..:.|..|.|..:|   |.|.|.::.:
Zfish   425 DGLEKPLESGRFNKVWKKIGVWNSNTGLNLTDSNKDKNTNVTDSMAN---RTLIVTTILE----- 481

  Fly   246 LYPNNAVVKASMQDYVSGFSPRNCTFFACSSISAPFVEADCILGLEMRILGFMKNRLKFDVNQTC 310
                |..|.....|                   .|....|...|..:.:|..:.|.|.|......
Zfish   482 ----NPYVMYKKSD-------------------KPLYGNDRFEGYCLDLLKELSNILGFSYEVKL 523

  Fly   311 SLESR-GEMDGPANWTGLLGKVQNNECDFVFGGYYPDNEVADHFWGSD--------TYLQDAHTW 366
            ..:.: |..:....|.|::                  .|:.||.  :|        ||:::
Zfish   524 VTDGKYGAQNDKGEWNGMV------------------RELIDHV--ADLAVAPLTITYVRE---- 564

  Fly   367 YIKMADRRPAWQAL-------------VGIFEAYT------W-------IGFILILIISWLF--- 402
              |:.|....:..|             .|:|....      |       :|...:|.:...|
Zfish   565 --KVIDFSKPFMTLGISILYHKPNGTNPGVFSFLNPLSPDIWMYVLLACLGVSCVLFVIARFTPY 627

  Fly   403 -WFTLVMILPEPKYYQQLSLTAINALAVTISIAVQE----RPICETTRLFFMALTLYGLNVVATY 462
             |:......|:....:. :.|.||::...:...:|:    .|...:||:.......:.|.::::|
Zfish   628 EWYNPHPCNPDSDVVEN-NFTLINSVWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSY 691

  Fly   463 TSKMIA-----TFQDPGYLHQLDELTEVVAAGIPFGGHEE--SRDWFEND-----DDMWIFNGYN 515
            |:.:.|     ....|  :...|:|.:  ...|.:|...:  :..:|:..     :.||
Zfish   692 TANLAAFLTVERMDSP--IDSADDLAK--QTKIEYGAVRDGSTMTFFKKSKISTYEKMW------ 746

  Fly   516 ISPEFIPQSKNLEAVKWGQRCILSNRMYTMQSPLADVIYAFPNNVFSSPVQMIMKAGFPFLFEMN 580
               .|:...||...||       :||                     ..:|.::...:..|.|..
Zfish   747 ---AFMSSRKNTALVK-------NNR---------------------EGIQRVLTTDYALLMEST 780

  Fly   581 SIIRL---------------MRDVGIFQKIDADFRYNNTYL-------NRINKMRPQF------P 617
            ||..:               .:..|:...|.:.:|...|..       .:::.|:.::      |
Zfish   781 SIEYISQRNCNLTQIGGLIDSKGYGVGTPIGSPYRDKVTIAILQLQEEGKLHMMKEKWWRGNGCP 845

  Fly   618 E----TAIVLTTEHLKGPFFILVVGSCWAALTFIGELI 651
            |    .|..|..|::.|.|.:|..|...:....|||.|
Zfish   846 EEDSKEASALGVENIGGIFIVLAAGLVLSVFVAIGEFI 883

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir60a	NP_611901.1	None
grik1b	XP_690040.5	Periplasmic_Binding_Protein_Type_1	62..455	CDD:299141	32/224 (14%)
		ANF_receptor	80..423	CDD:279440	31/192 (16%)
		Periplasmic_Binding_Protein_Type_2	471..840	CDD:304360	70/467 (15%)
		Lig_chan	602..871	CDD:278489	50/310 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591585
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.930