Protein Alignment Ir60a and grin2bb

DIOPT Version :10

• Sequence 1: NP_611901.1
• Gene: Ir60a / 37881
• FlyBaseID: FBgn0034994
• Length: 716
• Species: Drosophila melanogaster
• Sequence 2: NP_001121809.1
• Gene: grin2bb / 559976
• ZFINID: ZDB-GENE-061207-27
• Length: 1770
• Species: Danio rerio
• Alignment Length: 582
• Identity: 99/582 - (17%)
• Similarity: 207/582 - (35%)
• Gaps: 152/582 - (26%)

  Fly   165 RSWNPG--ARFLVLFHNATCRNRPLGVASNIFKDLMEMFYVH-RVALLYANSTMNYNLLVNDYYS 226
            :|.||.  .|:|:   |.|...|.|..:.       :.|.:| ::.::..|....|
Zfish   405 KSGNPNEVLRYLM---NVTFEGRNLSFSE-------DGFQMHPKLVIILLNKERQY--------- 450

  Fly   227 NVNCRILNVQSVGQCHDGKLYPNNAVVKASMQDYV-------SGFSPRNCTFFACSSI-SAPFV- 282
                     :.||:..:|.|         :|:.:|       |....|.....:..:: .||||
Zfish   451 ---------ERVGKWENGSL---------AMKYHVWPRFELYSDAEEREDDHLSIVTLEEAPFVI 497

  Fly   283 --EADCILGLEMRILGFMKNRLKFD---------VNQTCS---------------------LESR 315
              :.|.:.|..||.....:.:||..         :.:.|.                     |.:.
Zfish   498 VEDVDPLSGTCMRNTVPCRKQLKLQNLTGDSGIYIKRCCKGFCIDILKKIAKSVKFTYDLYLVTN 562

  Fly   316 GEMDGPAN--WTGLLGKVQNNECDFVFGGYYPDNEVADHFWGSDTYLQDAHTWYIKMADRRPAWQ 378
            |:.....|  |.|::|:|.........|....:.|.::....|..:::...:..:..::...:..
Zfish   563 GKHGKKINGTWNGMVGEVVLKNAHMAVGSLTINEERSEVIDFSVPFIETGISVMVSRSNGTVSPS 627

  Fly   379 ALVGIFEAYTWI-GFILILIISWLFWFTLVMILP--------------EPKYYQQLSLTAINALA 428
            |.:..|.|..|: .|:::||:|.:..|......|              .|.:....::..:..|.
Zfish   628 AFLEPFSADVWVMMFVMLLIVSAVAVFVFEYFSPVGYNRCLADGREPGGPSFTIGKAIWLLWGLV 692

  Fly   429 VTISIAVQERPICETTRLFFMALTLYGLNVVATYTSKMIATFQDPGYLHQLDELTE--------- 484
            ...|:.|| .|...|:::.......:.:..:|:||:.:.|......|:.|:..|::
Zfish   693 FNNSVPVQ-NPKGTTSKIMVSVWAFFAVIFLASYTANLAAFMIQEEYVDQVTGLSDKKFQHPNDF 756

  Fly   485 ---VVAAGIPFGGHEES--RDWFENDDDMWIFNGYNISPEFIPQSKNLEAVKWGQ-------RCI 537
               .....:|.|..|.:  .::.|....|..|:..|:       ::.|.::|.|:       ..:
Zfish   757 SPPFRFGTVPNGSTERNIRNNYKEMHSYMTSFHQKNV-------NEALHSLKSGKLDAFIYDAAV 814

  Fly   538 LSN--------RMYTMQSPLADVIYAFPNNVFSSPVQMIMKAGFPFLFEMNSIIRLMRDVGIFQK 594
            |:.        ::.|:.|.     |.|....:...:|  ..:|:....:: :|::|..| |..::
Zfish   815 LNYMAGRDEGCKLVTIGSG-----YIFATTGYGIAIQ--KDSGWKRAVDL-AILQLFGD-GEMEE 870

  Fly   595 IDADFRYNNTYLNRINKMRPQFPETAIVLTTEHLKGPFFILVVGSCWAALTFIGELIIHRWR 656
            ::|.:.....:..:...|..|       |..:::.|.|::|......:.:|||.|.:.: |:
Zfish   871 LEALWLTGICHNEKNEVMSSQ-------LDVDNMAGVFYMLGAAMALSLITFIAEHLFY-WQ 924

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir60a	NP_611901.1	None
grin2bb	NP_001121809.1	PBP1_iGluR_NMDA_NR2	107..465	CDD:380601	18/96 (19%)
		PBP2_iGluR_NMDA_Nr2	482..882	CDD:270436	67/416 (16%)
		NMDAR2_C	919..1770	CDD:463148	1/7 (14%)