DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir60a and grid2

DIOPT Version :9

Sequence 1:	NP_611901.1	Gene:	Ir60a / 37881	FlyBaseID:	FBgn0034994	Length:	716	Species:	Drosophila melanogaster
Sequence 2:	NP_001004123.1	Gene:	grid2 / 448841	ZFINID:	ZDB-GENE-040913-1	Length:	1009	Species:	Danio rerio

Alignment Length:	653	Identity:	124/653 - (18%)
Similarity:	226/653 - (34%)	Gaps:	156/653 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   101 INEAVTNPGPPDREELFQMRVASDYNITNGTEDKGELILADNYVIVVDSVDRLKELMKKKIVEMR 165
            ||.::.:|..|..:.|         .|||            .|  :.|:|..|.....:|: |.|
Zfish   305 INTSLCDPKDPKAQML---------EITN------------RY--IYDTVLLLANTFHRKL-EDR 345

  Fly   166 SWNPGARFLVLFHNATC---RNRPLGVASNIFKDLMEMFYVHRVALLY-----ANSTMNYNLLVN 222
            .|:..|       :.:|   .::|.....::.:.:.:.......:||.     :|..:::.:|..
Zfish   346 KWHSMA-------SLSCIRKGSKPWQGGKSMLETVKKGGVSGLTSLLEFNDNGSNPNIHFEILGT 403

  Fly   223 DYYSNVNCRILNVQSVGQCHDGKLYPNNAVVKASMQDYVSGFSPRNCTFFACSSISAPFV-EADC 286
            :|..:....:..:.:....|.    .|..:....:::.:.|...|..|.     :..||| .::.
Zfish   404 NYGEDRGRGVSRLATWDPIHG----LNGTLTDRKLENNMRGVVLRVVTV-----LEEPFVMVSEN 459

  Fly   287 ILGLEMRILGF-------MKNRLKFDVNQTCSLESR-GEMDGPANWTGLLGKVQNNECDFVFGG- 342
            :||...:..||       :.|.|.|......:.:.: |.......|.||:|::.....|.....
Zfish   460 VLGKPKKYQGFSIDVLDALANYLGFKYEIYVAPDHKYGSQQADGTWNGLIGELVFKRADVGLSAL 524

  Fly   343 -YYPDNEVADHFWGSDTYLQDAHTWYIKMADRRPAWQALVGIFEAYTW---IGFILILIISWLFW 403
             ..|:.|....|  :..|:..:....::.|:|.....|.:..|:...|   .|.:|::
Zfish   525 TITPERESVVDF--TTRYMDYSVGVLLRKAERTVDMFACLAPFDLSLWACIAGTVLLV------- 580

  Fly   404 FTLVMIL-----PEPKYYQQLSLTAINALAVTISIAVQ---ERPICE-TTRLFFMALTLYGLNVV 459
            .|||.:|     |........|.|..|::.......||   |.|... .||:......|:.|.|:
Zfish   581 GTLVYLLNWLNPPRLPMGSVSSTTLYNSMWFVYGSFVQQGGEVPYTTLATRMMMGVWWLFALIVI 645

  Fly   460 ATYTSKMIATFQDPGYLHQLDELTEVV-AAGIPFGGHEESRDW----------FEND---DDMW- 509
            ::||:.:.|........:.:..|.::. ...:|:|...:|..:          ||.|   ..||
Zfish   646 SSYTANLAAFLTISRIENSIQSLQDLAKQTDLPYGTVLDSAVYDQVRSKGMNPFERDPMYSQMWR 710

  Fly   510 IFNGYNISPEFIPQSK-NLEAVKWGQRCILSNRMYTMQSPLAD---VIYAFPNNVFSSPVQMIMK 570
            :.|....:...:.:|| .:..||:|:...:.:........:.|   .:|...|||......|.|:
Zfish   711 MINRTGGAENNVEESKEGIRKVKYGRFAFVWDAAVLEYVAINDEDCSLYTVSNNVADRGYGMAMQ 775

  Fly   571 AGFPFLFEMNSIIRLMRDVGIFQKIDADFRYNNTYLNRINKMRPQFP--------------ETAI 621
            .|.|:           ||  ||.:...:.:.|...  .|.|:: .:|              ::..
Zfish   776 HGSPY-----------RD--IFSQRILELQQNGDM--DILKLK-WWPRDSPCDLYSPVGTRKSGS 824

  Fly   622 VLTTEHLKGPFFILVVG---SCWAALTFIGELIIHRWRTQLVSTSEQQDRRSDKRRRRRRRRKPE 683
            .|......|.||:|..|   ||..|       .:..|.|                 ||:..|.|.
Zfish   825 ALDIHSFAGVFFVLAAGVVLSCLIA-------TVETWWT-----------------RRKGSRVPS 865

  Fly   684 KDN 686
            |::
Zfish   866 KED 868

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir60a	NP_611901.1	None
grid2	NP_001004123.1	PBP1_iGluR_delta_2	28..427	CDD:107386	25/156 (16%)
		ANF_receptor	42..404	CDD:279440	23/129 (18%)
		PBP2_iGluR_delta_2	440..806	CDD:270449	81/395 (21%)
		Lig_chan	568..841	CDD:278489	60/295 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	989..1009
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591512
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.740