DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir60a and GluRIA

DIOPT Version :9

Sequence 1:	NP_611901.1	Gene:	Ir60a / 37881	FlyBaseID:	FBgn0034994	Length:	716	Species:	Drosophila melanogaster
Sequence 2:	NP_476855.1	Gene:	GluRIA / 38742	FlyBaseID:	FBgn0004619	Length:	991	Species:	Drosophila melanogaster

Alignment Length:	735	Identity:	128/735 - (17%)
Similarity:	248/735 - (33%)	Gaps:	217/735 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    95 EGFSKLINEAVTNPGPPD--REELFQMRV--ASDYNITNGTEDKGELI---LADNYVIVVDSVDR 152
            |.|::::.:      .||  |....|.|.  .|..:...||.:...|:   .:..:|...:..::
  Fly   341 EAFNRILRK------KPDQFRSNHLQRRSHGGSSSSSATGTNESSALLDCNTSKGWVTPWEQGEK 399

  Fly   153 LKELMKKKIVEMRSWNPGARFLVLFHNATCRNRPLGVASNIFKDLMEMFYVHRVALLYANSTMNY 217
            :..:::|  ||:...:...||                    .:|...:.|...|..:..|||:
  Fly   400 ISRVLRK--VEIDGLSGEIRF--------------------DEDGRRINYTLHVVEMSVNSTL-- 440

  Fly   218 NLLVNDYYSNVNCRILNVQSVGQCHDG----KLYPNNAVVKASMQDYVSGFSPRNCTFFACSSIS 278
                              |.|.:..|.    .|:.:|....:......:|...||.|:...|.:.
  Fly   441 ------------------QQVAEWRDDAGLLPLHSHNYASSSRSASASTGDYDRNHTYIVSSLLE 487

  Fly   279 APFVE------ADCILGLEMRILGFMKN---------RLKFDVNQTCSLESRGEMDG-------- 320
            .|::.      .:.::|.: |..|:.|:         .:|:::        |...||
  Fly   488 EPYLSLKQYTYGESLVGND-RFEGYCKDLADMLAAQLGIKYEI--------RLVQDGNYGAENQY 543

  Fly   321 -PANWTGLLGKVQNNECDFVFGGYYPDNE---VADHFWGSDTYLQDAHTWYIKMADRRPAWQALV 381
             |..|.|::|::...|.|..........|   |.|       :.:...|..|.:..::|..|. .
  Fly   544 APGGWDGMVGELIRKEADIAISAMTITAERERVID-------FSKPFMTLGISIMIKKPVKQT-P 600

  Fly   382 GIFEAYT------WIGFILILI-ISWLFWFTLVM---------------------------ILPE 412
            |:|....      ||..||..: :|::.:|....                           .|.|
  Fly   601 GVFSFLNPLSQEIWISVILSYVGVSFVLYFVTRFPPYEWRIVRRPQADSTAQQPPGIIGGATLSE 665

  Fly   413 PKYY----QQLSLTAINALAVTISIAVQERPICETT------RL------FF--MALTLYGLNVV 459
            |:.:    .....|.:|:...:::..:|:.  |:.|      |:      ||  :.::.|..|:.
  Fly   666 PQAHVPPVPPNEFTMLNSFWYSLAAFMQQG--CDITPPSIAGRIAAAVWWFFTIILISSYTANLA 728

  Fly   460 ATYT-SKMIATFQDPGYLHQLDELTEVVAAGIPFGGHEE--SRDWFENDDDMWIF---------N 512
            |..| .:|:|..:.|   ..|...|:|....:.:|...|  .|......:.||.:         :
  Fly   729 AFLTVERMVAPIKTP---EDLTMQTDVNYGTLLYGSTWEFFRRSQIGLHNKMWEYMNANQHHSVH 790

  Fly   513 GYNISPEFIPQSKNLEAVKWGQRCILSNRMYTMQSPLADVIYAFP--------NNVFSSPVQMIM 569
            .|:.....:.|||       |:..:|      ::||..:.:.|.|        .|:.:....:..
  Fly   791 TYDEGIRRVRQSK-------GKYALL------VESPKNEYVNARPPCDTMKVGRNIDTKGFGVAT 842

  Fly   570 KAGFPFLFEMNSIIRLMRDVGIFQKIDADFRYNNTYLNRINKMRPQFPETAIVLTTEHLKGPFFI 634
            ..|.|....:|..:..:::.|...:|...:.::.|..|     ..|...|...|:..::.|.::|
  Fly   843 PIGSPLRKRLNEAVLTLKENGELLRIRNKWWFDKTECN-----LDQETSTPNELSLSNVAGIYYI 902

  Fly   635 LVVGSCWAALTFIGELIIHRWRTQ----------------LVSTSEQQDRRSDKRRRRRRRRKPE 683
            |:.|...|.:..|.|........|                |.|::.|:|..||.....:.:...:
  Fly   903 LIGGLLLAVIVAIMEFFCRNKTPQLKSPGSNGSAGGVPGMLASSTYQRDSLSDAIMHSQAKLAMQ 967

  Fly   684 KDNRWQRQ---VQVAPVVRF 700
            ..:.:..:   |::|..||:
  Fly   968 ASSEYDERLVGVELASNVRY 987

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir60a	NP_611901.1	None
GluRIA	NP_476855.1	PBP1_iGluR_AMPA	41..453	CDD:107375	26/159 (16%)
		ANF_receptor	53..434	CDD:279440	20/120 (17%)
		PBP2_iGluR_AMPA	477..879	CDD:270433	76/436 (17%)
		Lig_chan	612..907	CDD:278489	56/317 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462542
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.830