DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir60a and gria3b

DIOPT Version :9

Sequence 1:	NP_611901.1	Gene:	Ir60a / 37881	FlyBaseID:	FBgn0034994	Length:	716	Species:	Drosophila melanogaster
Sequence 2:	NP_938174.1	Gene:	gria3b / 368416	ZFINID:	ZDB-GENE-030616-53	Length:	883	Species:	Danio rerio

Alignment Length:	530	Identity:	84/530 - (15%)
Similarity:	160/530 - (30%)	Gaps:	196/530 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   265 SPRNCTFFACSSISAPFVEADCILGLEMRILGFMKNRLKFDVNQT----CSLESRGE-------- 317
            |..|.|....:.:.||:|.             :.||.:..:.|:.    | ::...|
Zfish   409 SVENRTIVVTTIMEAPYVM-------------YKKNHMHLEGNEKYEGYC-VDLASEIAKHVGIK 459

  Fly   318 ------MDG--------PANWTGLLGKVQNNECDFVFGGYYP------DNEVADHFWGSDTYLQD 362
                  |||        ..:|.|::|::.....|....   |      ..||.|.   |..::..
Zfish   460 YRLSIVMDGKYGARDPETKSWNGMVGELVYGRADIAVA---PLTITLVREEVIDF---SKPFMSL 518

  Fly   363 AHTWYIKMADR-RPA------------WQALVGIFEAYTWIGFILILIISWLFWFTLVMILPEPK 414
            ..:..||...: :|.            |..:|     :.:||..::|.:...|          ..
Zfish   519 GISIMIKKPQKSKPGVFSFLDPLAYEIWMCIV-----FAYIGVSVVLFLVSRF----------SP 568

  Fly   415 YYQQLSLT-----------------AINALAVTISIAVQE----RPICETTRLFFMALTLYGLNV 458
            |..||..|                 ..|:|..::...:|:    .|...:.|:.......:.|.:
Zfish   569 YEWQLDETDEVKDPQTPPDPPNDFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLII 633

  Fly   459 VATYTS---------KMIATFQDPGYLHQLDELTEVVAAGIPFGGHEESRDWFEND-----DDMW 509
            :::||:         :|::..:.   ...|.:.||:....:..|   .::::|...     :.||
Zfish   634 ISSYTANLAAFLTVERMVSPIES---AEDLAKQTEIAYGTLDSG---STKEFFRRSKIAVYEKMW 692

  Fly   510 IF--------------NGY---------------NISPEFIPQSKNLEAVKWGQRCILSNRMYTM 545
            .:              :|.               :...|:|.|.|..:.:|.|..  |.::.|.:
Zfish   693 SYMKSAEPSVFAKTTPDGVARVRKSKGKFAFLLESTMNEYIEQRKPCDTMKVGGN--LDSKGYGV 755

  Fly   546 QSPLADVIYAFPNNVFSSPVQMIMKAGFPFLFEMNSIIRLMRDVGIFQKIDADFRYNNTYLNRIN 610
            .:|...   |..|.|                   |..:..:.:.|:..|:...:.|:.   ....
Zfish   756 ATPKGS---ALRNAV-------------------NLAVLKLNEQGLLDKLKNKWWYDK---GECG 795

  Fly   611 KMRPQFPETAIVLTTEHLKGPFFILVVGSCWAALTFIGELIIHRWRTQLVSTSEQQDRRSDKRRR 675
            .......:....|:..::.|.|:|||.|...|.:..:.|...                   |.|.
Zfish   796 SGGGDSKDKTSALSLSNVAGVFYILVGGLGLAMMVALIEFCY-------------------KSRA 841

  Fly   676 RRRRRKPEKD 685
            ..:|.|.||:
Zfish   842 EAKRLKLEKN 851

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir60a	NP_611901.1	None
gria3b	NP_938174.1	Periplasmic_Binding_Protein_Type_1	25..396	CDD:299141
		ANF_receptor	36..379	CDD:279440
		PBP2_iGluR_AMPA	412..794	CDD:270433	68/449 (15%)
		Lig_chan	544..824	CDD:278489	49/327 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591649
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.830