DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir60a and GluRIIC

DIOPT Version :9

Sequence 1:	NP_611901.1	Gene:	Ir60a / 37881	FlyBaseID:	FBgn0034994	Length:	716	Species:	Drosophila melanogaster
Sequence 2:	NP_608557.4	Gene:	GluRIIC / 33275	FlyBaseID:	FBgn0046113	Length:	940	Species:	Drosophila melanogaster

Alignment Length:	795	Identity:	148/795 - (18%)
Similarity:	255/795 - (32%)	Gaps:	261/795 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   143 YVIVVDSVD-----RLKELMKKK-----IVEMRSWNPGARFLVLFHNATCRNRPL---------- 187
            :.||.|:.|     ||::|::.:     :|.:|.::....|.|::.:.....|.:
  Fly   160 FTIVYDADDARAAARLQDLLQLREVHNDVVRVRKFHKDDDFRVMWKSIRGERRVVLDCEPNMLVE 224

  Fly   188 -----------GVASNIFKDLMEMFYVHRVALLYANSTMNYN-----LLVN----DY---YSNVN 229
                       |..::||...:|.:..|...|...|.|...|     ||||    .|   |..|.
  Fly   225 LLNSSTEFGLTGQYNHIFLTNLETYTDHLEELAADNETFAVNITAARLLVNPDPPPYSLPYGYVT 289

  Fly   230 CRILNVQSVGQCHDGKLY----PNNAVVKASMQDYVSGF--SPRNCTFFACSSISAPFVEAD--- 285
            .|           |..:|    |...::...:.|.:..|  |.||.:||....:..|.:..|
  Fly   290 QR-----------DNIVYESSDPPRTLIHDLIHDALQLFAQSWRNASFFYPDRMVVPRITCDFAA 343

  Fly   286 -----CILGLEMRIL----------GFMKNRLKFDVNQ---TCSLESRGEMD--GPANWTGLLGK 330
                 ..:|..:..|          .|..:.|:||.:.   |.::|....:|  |.|.|.. .|:
  Fly   344 SGGRTWAMGRYLARLMKGTSGVNNTNFRTSILQFDEDGQRITFNIEVYDPLDGIGIAIWDP-RGQ 407

  Fly   331 VQNNECDF----------------------------------VFGGYYPD--NEVADHFWGSDTY 359
            :.....|.                                  ::.||..|  :.:|.|......:
  Fly   408 ITQLNVDVKAQKKMIYRVATRIGPPYFSYNETARELNLTGNALYQGYAVDLIDAIARHVGFEYVF 472

  Fly   360 LQDAHTWYIKMADRRPAWQALVG-IFEAYTWIGFILILIISWLFWFTLVMILPEPKYYQQLSLTA 423
            :..|...|.|:......|..::| |......:|...:.|                   .|...||
  Fly   473 VPVADQQYGKLDKETKQWNGIIGEIINNDAHMGICDLTI-------------------TQARKTA 518

  Fly   424 IN----ALAVTISIAVQERPICETTRLFFMALTLYGLNV---------VATYTSKMIATF----- 470
            ::    .:.:.:||...:.|..|.|...::|  .:|..|         |.|:...::|..
  Fly   519 VDFTVPFMQLGVSILAYKSPHVEKTLDAYLA--PFGGEVWIWILISVFVMTFLKTIVARISKMDW 581

  Fly   471 -------QDPGYL------HQLDELT--EVVAAGIPFGGHEESRDWFENDDDMWIF-----NGYN 515
                   :||..|      |....||  .::.||............||  ...|||     |.|.
  Fly   582 ENPHPCNRDPEVLENQWRIHNTGWLTVASIMTAGCDILPRSPQVRMFE--ATWWIFAIIIANSYT 644

  Fly   516 IS-PEFIPQSK------NL------EAVKWGQRCILSNRMYTMQSPLADVIYAFPNNVFSSP--- 564
            .: ..|:..||      ||      :.||:|  .|.....|.:.:...:.:|....|:.::.
  Fly   645 ANLAAFLTSSKMEGSIANLKDLSAQKKVKFG--TIYGGSTYNLLADSNETVYRLAFNLMNNDDPS 707

  Fly   565 ---------VQMIMK--AGFPFLFEMNSIIRL------MRDVG---------IFQKIDADFRYN- 602
                     |..:.|  ..:.||.|..::...      :|.||         |.....|::|.|
  Fly   708 AYTKDNLEGVDRVRKNRGDYMFLMETTTLEYHREQNCDLRSVGEKFGEKHYAIAVPFGAEYRSNL 772

  Fly   603 NTYLNRINKMRPQF-------------------PETAIVLTTEHLKGPFFILVVGSCWAALTFIG 648
            :..:.::::....:                   |:....:|.|.|:|.|:.|..|...|.|..|.
  Fly   773 SVAILKLSERGELYDLKQKWWKNPNASCFEEPDPDATPDMTFEELRGIFYTLYAGILIAFLIGIT 837

  Fly   649 ELIIHRWRTQLVSTSEQQDRRSDKRRRRR------RRRKPEKDNRWQRQVQVAP------VVRFT 701
            |.:::   .|.|:..|:...:...::..|      ..|||.........|:..|      .:..|
  Fly   838 EFLVY---VQQVALEERLTFKDAFKKEIRFVLCVWNNRKPIVAGTPISSVRTTPRRSLDKSLDRT 899

  Fly   702 PVKRRKVFQGQTSQK 716
            |...|:|..|::|::
  Fly   900 PKSSRRVVIGRSSEE 914

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir60a	NP_611901.1	None
GluRIIC	NP_608557.4	PBP1_iGluR_Kainate	26..404	CDD:107377	53/254 (21%)
		Periplasmic_Binding_Protein_Type_1	<279..363	CDD:299141	18/94 (19%)
		PBP2_iGluR_Kainate	423..794	CDD:270432	66/395 (17%)
		Lig_chan	554..828	CDD:278489	50/277 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462632
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930