DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir60a and Ir21a

DIOPT Version :9

Sequence 1:	NP_611901.1	Gene:	Ir60a / 37881	FlyBaseID:	FBgn0034994	Length:	716	Species:	Drosophila melanogaster
Sequence 2:	NP_001097043.1	Gene:	Ir21a / 33157	FlyBaseID:	FBgn0031209	Length:	842	Species:	Drosophila melanogaster

Alignment Length:	791	Identity:	150/791 - (18%)
Similarity:	265/791 - (33%)	Gaps:	253/791 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 GVGCLD-----SFAQ-----IFFFRNPKERFTRAYNLMLVHAFHLSSPADQIQEGFSKLIN---E 103
            |||..|     .|.|     ..|..||:.|     ..:|...||::|...:.......|:|   :
  Fly    47 GVGMCDGNNENEFRQKRRIVPTFQGNPRPR-----GELLASKFHVNSYNFEQTNSLVGLVNKIAQ 106

  Fly   104 AVTNPGPP----DR----------EELFQM--------RVASDYNITNGTEDKGELILADNYVIV 146
            ...|..||    |.          |.||:.        .:.:||...|............:|::.
  Fly   107 EYLNKCPPVIYYDSFVEKSDGLILENLFKTIPITFYHGEINADYEAKNKRFTSHIDCNCKSYILF 171

  Fly   147 VDSVDRLKELMKKKIVEMRSWNPGARFLVLFHNATCRNRP-------------LGVASNIFKDLM 198
            :..     .||.:||:..::   .:|.:::..:...|.|.             |.:..::..|.|
  Fly   172 LSD-----PLMTRKILGPQT---ESRVVLVSRSTQWRLRDFLSSELSSNIVNLLVIGESLMADPM 228

  Fly   199 E----MFYVHRVALLYANST-MNYNLLVNDYYSNVNCRILNVQSVGQCHDGKLYPNNAVVKASMQ 258
            .    :.|.|:   |||:.. .|..:::..:...         ::.:.|. .|:|:.
  Fly   229 RERPYVLYTHK---LYADGLGSNTPVVLTSWIKG---------ALSRPHI-NLFPSK-------- 272

  Fly   259 DYVSGFSPRNCTFFACSSISAPFVEADCIL-----------GLEMRILGFMKNRLKFDVNQTCSL 312
             :..||:...  |...::...||:.....|           |:|.|:|..:..||.|.::.|
  Fly   273 -FQFGFAGHR--FQISAANQPPFIFRIRTLDSSGMGQLRWDGVEFRLLTMISKRLNFSIDIT--- 331

  Fly   313 ESRGEMDGPANWTGLLGKVQ----NNECDFVFGGYYPDNEVADHFWGSDTYLQDAHT----WYIK 369
                |....:|..|::..:|    ....|....|.|...|..     .|:.:...|:    .:|.
  Fly   332 ----ETPTRSNTRGVVDTIQEQIIERTVDIGMSGIYITQERL-----MDSAMSVGHSPDCAAFIT 387

  Fly   370 MADRR-PAWQALVGIFEAYTWIGFILI------------------LIISW-----LFWFTLVMIL 410
            :|.:. |.::|::|.|:...|:..|.:                  |:.:|     :||:...|
  Fly   388 LASKALPKYRAIMGPFQWPVWVALICVYLGGIFPIVFTDRLTLSHLMGNWGEVENMFWYVFGM-- 450

  Fly   411 PEPKYYQQLSLTAINALAVTISIAVQERPICETTRLFFMALTLYGLNVVATYTSKMIATFQDPGY 475
                :....|.|...:.:.|..         .:|||...|..|:.:.:.:.||..:||....|.:
  Fly   451 ----FTNAFSFTGKYSWSNTRK---------NSTRLLIGAYWLFTIIITSCYTGSIIAFVTLPAF 502

  Fly   476 LHQLDELTEVVAAGIPF-------GGHEESRDWFENDDDMWIFNGYNISPEFIPQS---KNLEAV 530
            ...:|.:.:::  |:.|       ||.|   .||:|.             ..||.|   |.:|.|
  Fly   503 PDTVDSVLDLL--GLFFRVGTLNNGGWE---TWFQNS-------------THIPTSRLYKKMEFV 549

  Fly   531 K--------------WGQRCILSNRM--YTMQSPLADVIYAFPNNV-------FSSPVQMIMKAG 572
            .              |....:.|...  |.:||..:|      .|:       .|.....:.:.|
  Fly   550 GSVDEGIGNVTQSFFWNYAFLGSKAQLEYLVQSNFSD------ENISRRSALHLSEECFALFQIG 608

  Fly   573 FPF------LFEMNSIIRLMRDVGIFQKIDADFRY--NNTYLNRI------NKMRPQFPETAIVL 623
            |.|      ..:::|:|.|.:..|:..||:.:..:  ..:...|:      |.:|....|.. .|
  Fly   609 FLFPRESVYKIKIDSMILLAQQSGLIAKINNEVSWVMQRSSSGRLLQASSSNSLREIIQEER-QL 672

  Fly   624 TTEHLKGPFFILVVGSCWAALTFIGEL----------IIHRWRTQLVST-----------SEQQD 667
            ||...:|.|.::.:|....|...:.|:          ||.|.|....|:           :..:.
  Fly   673 TTADTEGMFLLMALGYFLGATALVSEIVGGITNKCRQIIKRSRKSAASSWSSASSGSMLRTNAEQ 737

  Fly   668 RRSDKRRRRRR 678
            ...|||:..||
  Fly   738 LSHDKRKANRR 748

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir60a	NP_611901.1	None
Ir21a	NP_001097043.1	Periplasmic_Binding_Protein_Type_2	289..583	CDD:304360	66/338 (20%)
Ir21a	NP_001097043.1	Lig_chan	407..662	CDD:278489	54/293 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810