DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ir60a and Gria4

DIOPT Version :9

Sequence 1:NP_611901.1 Gene:Ir60a / 37881 FlyBaseID:FBgn0034994 Length:716 Species:Drosophila melanogaster
Sequence 2:NP_001106655.1 Gene:Gria4 / 29629 RGDID:61863 Length:902 Species:Rattus norvegicus


Alignment Length:707 Identity:124/707 - (17%)
Similarity:197/707 - (27%) Gaps:344/707 - (48%)


- Green bases have known domain annotations that are detailed below.


  Fly    49 WKAGVGCLDSFAQI--FFFRNPKERFTRAYNLMLVH---------AFHLSSPADQIQEGFSKLIN 102
            |...:|...|..||  .|.||..:.:|.....:.:|         .|:|....|.|:...|..:.
  Rat    16 WGLAMGAFPSSVQIGGLFIRNTDQEYTAFRLAIFLHNTSPNASEAPFNLVPHVDNIETANSFAVT 80

  Fly   103 EA-----------------------------------VTNPGPPDREELFQMRVASDYNITNGTE 132
            .|                                   :|...|.:.|..|.:::....       
  Rat    81 NAFCSQYSRGVFAIFGLYDKRSVHTLTSFCSALHISLITPSFPTEGESQFVLQLRPSL------- 138

  Fly   133 DKGELI-LADNY-----VIVVDSVDR----LKELMKKKIVEMRSWNPGARFLVLFHNATCRNRPL 187
             :|.|: |.|:|     |.:.|: ||    |:.:|:|  .....|:..|..:..|::.:.|    
  Rat   139 -RGALLSLLDHYEWNCFVFLYDT-DRGYSILQAIMEK--AGQNGWHVSAICVENFNDVSYR---- 195

  Fly   188 GVASNIFKDL---MEMFYVHRVALLYANSTMNYNLLVNDYYSNVNCRILNVQ-------SVGQCH 242
                .:.::|   .|..:|                        ::|.|..:|       |||:..
  Rat   196 ----QLLEELDRRQEKKFV------------------------IDCEIERLQNILEQIVSVGKHV 232

  Fly   243 DGKLY--PNNAVVKASMQDYVSGFSPRNCTFFACSSISAPFV----------------------- 282
            .|..|  .|......|::.::.|.:  |.|.|.....:.|.|                       
  Rat   233 KGYHYIIANLGFKDISLERFIHGGA--NVTGFQLVDFNTPMVTKLMDRWKKLDQREYPGSETPPK 295

  Fly   283 --------------------------------EADCIL--------GLEM-------RILGFMKN 300
                                            ..||:.        |::|       ||.|...|
  Rat   296 YTSALTYDGVLVMAETFRSLRRQKIDISRRGNAGDCLANPAAPWGQGIDMERTLKQVRIQGLTGN 360

  Fly   301 RLKFD-----VNQTC---SLESRGEMDGPAN---WTGL-----------LGK----VQNN----- 334
             ::||     ||.|.   .|:|    .||..   |..:           ||.    ::|.     
  Rat   361 -VQFDHYGRRVNYTMDVFELKS----TGPRKVGYWNDMDKLVLIQDMPTLGNDTAAIENRTVVVT 420

  Fly   335 ---ECDFV--------------FGGYYPD--NEVADHF-------------WGSDTYLQDAHTWY 367
               |..:|              :.||..|  :|:|.|.             :|:    :||.|  
  Rat   421 TIMESPYVMYKKNHEMFEGNDKYEGYCVDLASEIAKHIGIKYKIAIVPDGKYGA----RDADT-- 479

  Fly   368 IKMADRRPAWQALVGIFEAYTWIGFILILIISWLFWFTLVMILPEPKYYQQLSLTAINALAVTIS 432
                   ..|..:||                ..::....:.|.|       |::|.:....:..|
  Rat   480 -------KIWNGMVG----------------ELVYGKAEIAIAP-------LTITLVREEVIDFS 514

  Fly   433 IAVQERPICETTRLFFMALTLYGLNVVATYTSKMIATFQDPGYLHQLDELTE-----VVAAGI-- 490
                 :|        ||:|   |::::.....|     ..||....||.|..     :|.|.|  
  Rat   515 -----KP--------FMSL---GISIMIKKPQK-----SKPGVFSFLDPLAYEIWMCIVFAYIGV 558

  Fly   491 -----------PFGGH-EESRDWFENDDD-----MWIFN------------GYNISP 518
                       |:..| ||..|..|...|     ..|||            |.:|||
  Rat   559 SVVLFLVSRFSPYEWHTEEPEDGKEGPSDQPPNEFGIFNSLWFSLGAFMQQGCDISP 615

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ir60aNP_611901.1 None
Gria4NP_001106655.1 PBP1_iGluR_AMPA_GluR4 28..398 CDD:107383 70/419 (17%)
ANF_receptor 39..380 CDD:279440 60/386 (16%)
PBP2_iGluR_AMPA_GluR4 414..795 CDD:270445 49/259 (19%)
Lig_chan 546..825 CDD:278489 17/70 (24%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C166350088
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1052
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.830

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