DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ir60a and GRIN2B

DIOPT Version :10

Sequence 1:NP_611901.1 Gene:Ir60a / 37881 FlyBaseID:FBgn0034994 Length:716 Species:Drosophila melanogaster
Sequence 2:NP_000825.2 Gene:GRIN2B / 2904 HGNCID:4586 Length:1484 Species:Homo sapiens


Alignment Length:487 Identity:83/487 - (17%)
Similarity:168/487 - (34%) Gaps:125/487 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly   235 VQSV----GQCHDGKLYPNNAVVKASMQDYVSGFSPRNCTFFACSSISAPFVEADCILGLEMRIL 295
            |:||    |.|....:.....:|..:..|...|:..:.|..|             ||     .||
Human   419 VESVDPLSGTCMRNTVPCQKRIVTENKTDEEPGYIKKCCKGF-------------CI-----DIL 465

  Fly   296 GFMKNRLKFDVNQTCSLESRGEMDGPAN--WTGLLGKVQNNECDFVFGGYYPDNEVADHFWGSDT 358
            ..:...:||..:  ..|.:.|:.....|  |.|::|:|.........|....:.|.::....|..
Human   466 KKISKSVKFTYD--LYLVTNGKHGKKINGTWNGMIGEVVMKRAYMAVGSLTINEERSEVVDFSVP 528

  Fly   359 YLQDAHTWYIKMADRRPAWQALVGIFEAYTWI-GFILILIISWLFWFTLVMILP----------- 411
            :::...:..:..::...:..|.:..|.|..|: .|:::||:|.:..|......|           
Human   529 FIETGISVMVSRSNGTVSPSAFLEPFSADVWVMMFVMLLIVSAVAVFVFEYFSPVGYNRCLADGR 593

  Fly   412 ---EPKYYQQLSLTAINALAVTISIAVQERPICETTRLFFMALTLYGLNVVATYTSKMIATFQDP 473
               .|.:....::..:..|....|:.|| .|...|:::.......:.:..:|:||:.:.|.....
Human   594 EPGGPSFTIGKAIWLLWGLVFNNSVPVQ-NPKGTTSKIMVSVWAFFAVIFLASYTANLAAFMIQE 657

  Fly   474 GYLHQLDELTEVVAAGIPFGGHEESRDWFENDDDMWIFNGYNISPEF----IPQSKNLEAV---- 530
            .|:.|:..|::               ..|:..:|        .||.|    :|.......:    
Human   658 EYVDQVSGLSD---------------KKFQRPND--------FSPPFRFGTVPNGSTERNIRNNY 699

  Fly   531 --------KWGQR----CILSNRMYTMQSPLAD---------------VIYAFPNNVFSSPVQMI 568
                    |:.||    .:||.:...:.:.:.|               ::......||:|     
Human   700 AEMHAYMGKFNQRGVDDALLSLKTGKLDAFIYDAAVLNYMAGRDEGCKLVTIGSGKVFAS----- 759

  Fly   569 MKAGFPFLFEMNS---------IIRLMRDVGIFQKIDADFRYNNTYLNRINKMRPQFPETAIVLT 624
              .|:....:.:|         |::|..| |..::::|.:.....:..:...|..|       |.
Human   760 --TGYGIAIQKDSGWKRQVDLAILQLFGD-GEMEELEALWLTGICHNEKNEVMSSQ-------LD 814

  Fly   625 TEHLKGPFFILVVGSCWAALTFIGELIIHRWR 656
            .:::.|.|::|......:.:|||.|.:.: |:
Human   815 IDNMAGVFYMLGAAMALSLITFICEHLFY-WQ 845

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ir60aNP_611901.1 None
GRIN2BNP_000825.2 PBP1_iGluR_NMDA_NR2 33..388 CDD:380601
PBP2_iGluR_NMDA_Nr2 403..803 CDD:270436 72/435 (17%)
Pore-forming. /evidence=ECO:0000250|UniProtKB:A7XY94 604..623 4/19 (21%)
NMDAR2_C 840..1484 CDD:463148 1/7 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1074..1097
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1161..1194
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1271..1301
Interaction with DAPK1. /evidence=ECO:0000250|UniProtKB:Q01097 1292..1304
PDZ-binding. /evidence=ECO:0000250 1482..1484
Blue background indicates that the domain is not in the aligned region.

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