Protein Alignment Ir60a and GRIK5

DIOPT Version :9

• Sequence 1: NP_611901.1
• Gene: Ir60a / 37881
• FlyBaseID: FBgn0034994
• Length: 716
• Species: Drosophila melanogaster
• Sequence 2: XP_011525167.1
• Gene: GRIK5 / 2901
• HGNCID: 4583
• Length: 982
• Species: Homo sapiens
• Alignment Length: 580
• Identity: 106/580 - (18%)
• Similarity: 197/580 - (33%)
• Gaps: 160/580 - (27%)

  Fly   183 RNRPLGV------ASNIFKDLMEMFYVHRVALLYANSTMNYNLLVNDY--------------YSN 227
            |::.:||      ::||:.              :..|.|||..:| :|              .:|
Human   323 RSQEIGVKPLACTSANIWP--------------HGTSLMNYLRMV-EYDGLTGRVEFNSKGQRTN 372

  Fly   228 VNCRILNVQSVGQCHDGKLYPNNAV-VKASMQDYVSGFSPRNCTFFACSSISAPFV----EADCI 287
            ...|||.....|....|..|.|..: :.|:..|.....:..|.|....:.:..|:|    ....:
Human   373 YTLRILEKSRQGHREIGVWYSNRTLAMNATTLDINLSQTLANKTLVVTTILENPYVMRRPNFQAL 437

  Fly   288 LGLEMRILGFMKNRLKFDVNQTCSLESR---------GEMDGPANWTGLLGKVQNNE-CDFVFGG 342
            .|.| |..||..:.|: ::.:......|         |..:...:|||::|::.|.: .|.....
Human   438 SGNE-RFEGFCVDMLR-ELAELLRFRYRLRLVEDGLYGAPEPNGSWTGMVGELINRQKADLAVAA 500

  Fly   343 Y--YPDNEVADHFWGSDTYLQDAHTWYIKMADRRPAWQALVGIFEAYTWIGFILI--LIISWLF- 402
            :  ..:.|....|......|..:..:.:.|. |:|.:.:.:..|....|: |:|:  |.:|.:.
Human   501 FTITAEREKVIDFSKPFMTLGISILYRVHMG-RKPGYFSFLDPFSPAVWL-FMLLAYLAVSCVLF 563

  Fly   403 ---------WFTLVMILPEPKYYQQLSLTAINALAVTISIAVQE----RPICETTRLFFMALTLY 454
                     |:.....|....:..:...|..|:|...:...:|:    .|...:||........:
Human   564 LAARLSPYEWYNPHPCLRARPHILENQYTLGNSLWFPVGGFMQQGSEIMPRALSTRCVSGVWWAF 628

  Fly   455 GLNVVATYTSKMIA-----TFQDPGYLHQLDELTE-------VVAAGIPFGGHEESRDWFENDDD 507
            .|.::::||:.:.|     ..:.|  :...|:|.:       .:.||......:.||  ::....
Human   629 TLIIISSYTANLAAFLTVQRMEVP--VESADDLADQTNIEYGTIHAGSTMTFFQNSR--YQTYQR 689

  Fly   508 MWIFNGYNISPEFIPQSKNLEAVKWGQRCILSNRMYTMQSPLADVIYAFPNNVFSSPVQMIMKAG 572
            ||.:                                 |||....|   |..:. ...:..::.:.
Human   690 MWNY---------------------------------MQSKQPSV---FVKST-EEGIARVLNSR 717

  Fly   573 FPFLFE--MNSIIRLM-------------RDVGIFQKIDADFRYNNTYL-------NRINKMRPQ 615
            :.||.|  ||...|.:             :..||...:.:.||...|..       ||:..::.:
Human   718 YAFLLESTMNEYHRRLNCNLTQIGGLLDTKGYGIGMPLGSPFRDEITLAILQLQENNRLEILKRK 782

  Fly   616 FPE----------TAIVLTTEHLKGPFFILVVGSCWAALTFIGELIIHRWRTQLVSTSEQ 665
            :.|          .|..|..|::.|.|.:|:.|...|....:.|.|   |.|:..:.||:
Human   783 WWEGGRCPKEEDHRAKGLGMENIGGIFIVLICGLIIAVFVAVMEFI---WSTRRSAESEE 839

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir60a	NP_611901.1	None
GRIK5	XP_011525167.1	PBP1_iGluR_Kainate_KA1_2	25..399	CDD:107389	19/90 (21%)
		ANF_receptor	42..379	CDD:279440	14/70 (20%)
		Periplasmic_Binding_Protein_Type_2	414..785	CDD:304360	70/415 (17%)
		Lig_chan	546..816	CDD:278489	52/311 (17%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156162
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840