Protein Alignment Ir60a and GRIK3

DIOPT Version :10

• Sequence 1: NP_611901.1
• Gene: Ir60a / 37881
• FlyBaseID: FBgn0034994
• Length: 716
• Species: Drosophila melanogaster
• Sequence 2: NP_000822.2
• Gene: GRIK3 / 2899
• HGNCID: 4581
• Length: 919
• Species: Homo sapiens
• Alignment Length: 865
• Identity: 152/865 - (17%)
• Similarity: 283/865 - (32%)
• Gaps: 315/865 - (36%)

  Fly    73 TRAYNLMLVHAFHLSSPA-----DQIQEGFSKLIN----------EAVTNP------------GP 110
            |..|::..:| ||.|..|     ||:..|...:..          :::.|.            .|
Human    78 TLTYDIQRIH-FHDSFEATKKACDQLALGVVAIFGPSQGSCTNAVQSICNALEVPHIQLRWKHHP 141

  Fly   111 PDREELFQMRVASDY-NITNGTEDKGELILADNYVIVVD---SVDRLKEL--------MKKKIVE 163
            .|.::.|.:.:..|| ::::...|..:.:...:..:|.|   .:.||:||        ::.||.:
Human   142 LDNKDTFYVNLYPDYASLSHAILDLVQYLKWRSATVVYDDSTGLIRLQELIMAPSRYNIRLKIRQ 206

  Fly   164 -----------MRSWNPGARFLVLFHNATCRNRPLGVASNIFKDLMEM----FYVHRVALLYANS 213
                       ::....|..|.::|   .|.:.   :|:.|.|..|.|    .|.|     :..:
Human   207 LPIDSDDSRPLLKEMKRGREFRIIF---DCSHT---MAAQILKQAMAMGMMTEYYH-----FIFT 260

  Fly   214 TMN-YNLLVNDY-YSNVNC---RILNVQSVG---------------------------------- 239
            |:: |.|.:..| ||.||.   |||||.:..
Human   261 TLDLYALDLEPYRYSGVNLTGFRILNVDNPHVSAIVEKWSMERLQAAPRSESGLLDGVMMTDAAL 325

  Fly   240 -----------------------QCHDGKLYP-----NNAVVKASMQ------------------ 258
                                   |||..|.:.     .|.:.:|..:
Human   326 LYDAVHIVSVCYQRAPQMTVNSLQCHRHKAWRFGGRFMNFIKEAQWEGLTGRIVFNKTSGLRTDF 390

  Fly   259 --DYVS-------------------------GFSPR------NCTFFACSSISAPFV-------- 282
              |.:|                         |..|.      |.:....:.:..|||
Human   391 DLDIISLKEDGLEKVGVWSPADGLNITEVAKGRGPNVTDSLTNRSLIVTTVLEEPFVMFRKSDRT 455

  Fly   283 -------EADCILGLE--MRILGFMKNRLKFDVNQTCSLESR-------GEMDGPANWTGLLGKV 331
                   |..||..|:  ..||||             |.|.|       |..|....|.|::.::
Human   456 LYGNDRFEGYCIDLLKELAHILGF-------------SYEIRLVEDGKYGAQDDKGQWNGMVKEL 507

  Fly   332 QNNECDFVFGGYYPDN--EVADHFWGSDTYLQDAHTWYIKMADRRP-----------------AW 377
            .:::.|.........:  |.|..|  |..::    |..:.:..|:|                 .|
Human   508 IDHKADLAVAPLTITHVREKAIDF--SKPFM----TLGVSILYRKPNGTNPSVFSFLNPLSPDIW 566

  Fly   378 QALVGIFEAYTWIGFILILI--ISWLFWFTLVMILPEPKYYQQLSLTAINALAVTISIAVQE--- 437
               :.:..||..:..:|.:|  .|...|:......|..:..:. :.|.:|:....:...:|:
Human   567 ---MYVLLAYLGVSCVLFVIARFSPYEWYDAHPCNPGSEVVEN-NFTLLNSFWFGMGSLMQQGSE 627

  Fly   438 -RPICETTRLFFMALTLYGLNVVATYTSKMIA-----TFQDPGYLHQLDELTEVVAAGIPFGGHE 496
             .|...:||:.......:.|.::::||:.:.|     ..:.|  :...|:|.:  ...|.:|..:
Human   628 LMPKALSTRIIGGIWWFFTLIIISSYTANLAAFLTVERMESP--IDSADDLAK--QTKIEYGAVK 688

  Fly   497 E--SRDWFEND-----DDMWIFNGYNISPEFIPQSKNLEAVKWGQRCILSNRMYTMQSPLADVIY 554
            :  :..:|:..     :.||.|  .:..|..:.:: |.|.:   ||.:.::....|:|  ..:.|
Human   689 DGATMTFFKKSKISTFEKMWAF--MSSKPSALVKN-NEEGI---QRALTADYALLMES--TTIEY 745

  Fly   555 AFPNNVFSSPV-QMIMKAGFPFLFEMNSIIRLMRDVGIFQKIDADFRYNNTYLNRINKMRPQF-- 616
            ....|...:.: .:|...|:.....|.|..|....:.|.|..:.|         :::.|:.::
Human   746 VTQRNCNLTQIGGLIDSKGYGIGTPMGSPYRDKITIAILQLQEED---------KLHIMKEKWWR 801

  Fly   617 ----PE----TAIVLTTEHLKGPFFILVVGSCWAALTFIGELIIHRWRTQLVSTSEQQDRR---- 669
                ||    .|..|..:.:.|.|.:|..|...:.|..:||.:.     :|..|:|::.|.
Human   802 GSGCPEEENKEASALGIQKIGGIFIVLAAGLVLSVLVAVGEFVY-----KLRKTAEREQRSFCST 861

  Fly   670 -SDKRR-----RRRRRRKPE 683
             :|:.|     :||.:.||:
Human   862 VADEIRFSLTCQRRVKHKPQ 881

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir60a	NP_611901.1	None
GRIK3	NP_000822.2	PBP1_iGluR_Kainate	37..417	CDD:380605	57/350 (16%)
		PBP2_iGluR_Kainate_GluR7	433..801	CDD:270441	72/411 (18%)