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Protein Alignment Ir60a and GRIK2

DIOPT Version :9

Sequence 1:	NP_611901.1	Gene:	Ir60a / 37881	FlyBaseID:	FBgn0034994	Length:	716	Species:	Drosophila melanogaster
Sequence 2:	NP_068775.1	Gene:	GRIK2 / 2898	HGNCID:	4580	Length:	908	Species:	Homo sapiens

Alignment Length:	771	Identity:	146/771 - (18%)
Similarity:	260/771 - (33%)	Gaps:	231/771 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 VNLSN----ETANTVIFMLPEKDLGPDVW---------KAGVGCLDSFAQIFFFRNPKERFTRAY 76
            ||::.    .|.||.:..:.||      |         |...|.||.|..           |.|
Human   274 VNMTGFRILNTENTQVSSIIEK------WSMERLQAPPKPDSGLLDGFMT-----------TDA- 320

  Fly    77 NLMLVHAFHLSSPADQIQEGFSKLINEAVTNPGPPDREELFQMRVAS--------------DYNI 127
             .::..|.|:.|.|  :|:.....::....|...|.|   |..|..|              .:|.
Human   321 -ALMYDAVHVVSVA--VQQFPQMTVSSLQCNRHKPWR---FGTRFMSLIKEAHWEGLTGRITFNK 379

  Fly   128 TNGTEDKGELILADNYVIVVDSVDRLKELMKKKIVEMRSWNPGARFLVLFHNATCRNRPLGVASN 192
            |||.....:|           .|..|||...:||   .:|:|.:..     |.|...:  |..:|
Human   380 TNGLRTDFDL-----------DVISLKEEGLEKI---GTWDPASGL-----NMTESQK--GKPAN 423

  Fly   193 IFKDLMEMFYVHRVALLYANSTMNYNLLVNDYYSNVNCRILNVQSVGQCHDGKLYPNNAVVKASM 257
            |...|             :|.::....::.:.|      :|..:|     |..||.|
Human   424 ITDSL-------------SNRSLIVTTILEEPY------VLFKKS-----DKPLYGN-------- 456

  Fly   258 QDYVSGFSPRNCTFFACSSISAPFVEADCILGL--EMRILGFMKNRLKFDVNQTCSLESRGEMDG 320
             |...|:         |..:   ..|...|||.  |:|::...|...:.|.|
Human   457 -DRFEGY---------CIDL---LRELSTILGFTYEIRLVEDGKYGAQDDAN------------- 495

  Fly   321 PANWTGLLGKVQNNECDFVFGGY---YPDNEVADHFWGSDTYLQDAHTWYIKMADRRP------- 375
             ..|.|::.::.:::.|......   |...:|.|       :.:...|..|.:..|:|
Human   496 -GQWNGMVRELIDHKADLAVAPLAITYVREKVID-------FSKPFMTLGISILYRKPNGTNPGV 552

  Fly   376 ----------AWQALVGIFEAYTWIGFILILI--ISWLFWFTLVMILPEPKYYQQLSLTAINALA 428
                      .|   :.|..||..:..:|.:|  .|...|:......|:....:. :.|.:|:..
Human   553 FSFLNPLSPDIW---MYILLAYLGVSCVLFVIARFSPYEWYNPHPCNPDSDVVEN-NFTLLNSFW 613

  Fly   429 VTISIAVQE----RPICETTRLFFMALTLYGLNVVATYTSKMIA-----TFQDPGYLHQLDELTE 484
            ..:...:|:    .|...:||:.......:.|.::::||:.:.|     ..:.|  :...|:|.:
Human   614 FGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMESP--IDSADDLAK 676

  Fly   485 VVAAGIPFGGHEE--SRDWFEND-----DDMWIFNGYNISPEFIPQSKNLEAVKWGQRCILSNRM 542
              ...|.:|..|:  :..:|:..     |.||.|  .:...:.:....|.|.:   ||.:.|:..
Human   677 --QTKIEYGAVEDGATMTFFKKSKISTYDKMWAF--MSSRRQSVLVKSNEEGI---QRVLTSDYA 734

  Fly   543 YTMQSPLADVIYAFPNNVFSSPVQMIMKAGFPFLFEMNSIIRLMRDVGIFQKIDADFRYNNTYLN 607
            :.|:|...:.:.....|: :....:|...|:.....|.|..|....:.|.|..:.         .
Human   735 FLMESTTIEFVTQRNCNL-TQIGGLIDSKGYGVGTPMGSPYRDKITIAILQLQEE---------G 789

  Fly   608 RINKMRPQF------PE----TAIVLTTEHLKGPFFILVVGSCWAALTFIGELII-HRWRTQLVS 661
            :::.|:.::      ||    .|..|..:::.|.|.:|..|...:....:||.:. .:...||..
Human   790 KLHMMKEKWWRGNGCPEEESKEASALGVQNIGGIFIVLAAGLVLSVFVAVGEFLYKSKKNAQLEK 854

  Fly   662 TS----EQQDRRSDKRRRRRRRRKPEKDNRWQRQVQVAPVVRFTPVKRRKVFQGQT 713
            .|    ..::.|...:.:||.:.||:           |||:    ||..:|....|
Human   855 RSFCSAMVEELRMSLKCQRRLKHKPQ-----------APVI----VKTEEVINMHT 895

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.