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Protein Alignment Ir60a and GRIA4

DIOPT Version :9

Sequence 1:	NP_611901.1	Gene:	Ir60a / 37881	FlyBaseID:	FBgn0034994	Length:	716	Species:	Drosophila melanogaster
Sequence 2:	NP_000820.4	Gene:	GRIA4 / 2893	HGNCID:	4574	Length:	902	Species:	Homo sapiens

Alignment Length:	772	Identity:	120/772 - (15%)
Similarity:	248/772 - (32%)	Gaps:	257/772 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 TVIFMLPEKDLGPDVWKAGVGCLDSFAQIFFFRNPKERFTRAYNLMLVHAFHLSSPADQIQEGFS 98
            :::..:.|| .|.:.|.....|:::|..: .:|...|...|...    ..|.:....:::|....
Human   165 SILQAIMEK-AGQNGWHVSAICVENFNDV-SYRQLLEELDRRQE----KKFVIDCEIERLQNILE 223

  Fly    99 KLINEA---------VTNPGPPDREELFQMRVASDYNITNGTEDKGELILADNYVIVVDSVDRLK 154
            ::::..         :.|.|..|        ::.:..|..|....|..::..|..:|:..:||.|
Human   224 QIVSVGKHVKGYHYIIANLGFKD--------ISLERFIHGGANVTGFQLVDFNTPMVIKLMDRWK 280

  Fly   155 E---------------------------------LMKKKIVEMRSWNPGARFLVLFHNATCRNRP 186
            :                                 |.::||...|..|.|          .|...|
Human   281 KLDQREYPGSETPPKYTSALTYDGVLVMAETFRSLRRQKIDISRRGNAG----------DCLANP 335

  Fly   187 L-------------------GVASNIFKDLMEMFYVHRVALLYANSTMNYNLLVN------DYYS 226
            .                   |:..|:..|    .|..||     |.||:...|.:      .|::
Human   336 AAPWGQGIDMERTLKQVRIQGLTGNVQFD----HYGRRV-----NYTMDVFELKSTGPRKVGYWN 391

  Fly   227 NVNCRIL--NVQSVGQCHDGKLYPNNAVVKASMQDYVSGFSPRNCTFFA--------CSSISAPF 281
            :::..:|  :|.::|  :|.....|..||..::.:.......:|...|.        |..:::..
Human   392 DMDKLVLIQDVPTLG--NDTAAIENRTVVVTTIMESPYVMYKKNHEMFEGNDKYEGYCVDLASEI 454

  Fly   282 VEADCILGLEMRILGFMKNRLKFDVNQTCSLESRGEMDGPAN-WTGLLGKVQNNECDFVFGGYYP 345
            .:.   :|::.:|......:.             |..|.... |.|::|::...:.:....   |
Human   455 AKH---IGIKYKIAIVPDGKY-------------GARDADTKIWNGMVGELVYGKAEIAIA---P 500

  Fly   346 ------DNEVADHFWGSDTYLQDAHTWYIKMADR-RPA------------WQALVGIFEAYTWIG 391
                  ..||.|.   |..::....:..||...: :|.            |..:|     :.:||
Human   501 LTITLVREEVIDF---SKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIV-----FAYIG 557

  Fly   392 FILILIISWLF----WFTLVMILPE-----PKYYQQLSLTAINALAVTISIAVQE----RPICET 443
            ..::|.:...|    |.|..   ||     |...........|:|..::...:|:    .|...:
Human   558 VSVVLFLVSRFSPYEWHTEE---PEDGKEGPSDQPPNEFGIFNSLWFSLGAFMQQGCDISPRSLS 619

  Fly   444 TRLFFMALTLYGLNVVATYTS---------KMIATFQDPGYLHQLDELTEVVAAGIPFGGHEESR 499
            .|:.......:.|.::::||:         :|::..:.   ...|.:.||:....:..|   .::
Human   620 GRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIES---AEDLAKQTEIAYGTLDSG---STK 678

  Fly   500 DWFEND-----DDMWIF--------------NGY---------------NISPEFIPQSKNLEAV 530
            ::|...     :.||.:              .|.               :...|:|.|.|..:.:
Human   679 EFFRRSKIAVYEKMWTYMRSAEPSVFTRTTAEGVARVRKSKGKFAFLLESTMNEYIEQRKPCDTM 743

  Fly   531 KWGQRCILSNRMYTMQSPLADVIYAFPNNVFSSPVQMIMKAGFPFLFEMNSIIRLMRDVGIFQKI 595
            |.|..  |.::.|.:.:|        ..:...:||.:             ::::| .:.|:..|:
Human   744 KVGGN--LDSKGYGVATP--------KGSSLRTPVNL-------------AVLKL-SEAGVLDKL 784

  Fly   596 DADFRYNNTYLNRINKMRPQ---FPETAIVLTTEHLKGPFFILVVGSCWAALTFIGE 649
            ...:.|:.      .:..|:   ..:....|:..::.|.|:|||.|...|.|..:.|
Human   785 KNKWWYDK------GECGPKDSGSKDKTSALSLSNVAGVFYILVGGLGLAMLVALIE 835

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.