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Protein Alignment Ir60a and GRIA2

DIOPT Version :9

Sequence 1:	NP_611901.1	Gene:	Ir60a / 37881	FlyBaseID:	FBgn0034994	Length:	716	Species:	Drosophila melanogaster
Sequence 2:	NP_000817.5	Gene:	GRIA2 / 2891	HGNCID:	4572	Length:	883	Species:	Homo sapiens

Alignment Length:	612	Identity:	102/612 - (16%)
Similarity:	204/612 - (33%)	Gaps:	183/612 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   143 YVIVVDSVDRLKELMKKKIVEMRSWNPGARFLVLFHNATCRNRPLGVASNIFKDLMEMFYVHRVA 207
            |..|....:..:.|.|::|...|..|.|.   .|.:.|.    |.|....|.:.|.::    :|.
Human   301 YDAVQVMTEAFRNLRKQRIEISRRGNAGD---CLANPAV----PWGQGVEIERALKQV----QVE 354

  Fly   208 LLYAN-------STMNYNLLVND----------YYSNVNCRILNVQSVGQCHDGKLYPNNAVVKA 255
            .|..|       ..:||.:.:.:          |:|.|:..::.:..:...:|.....|..||..
Human   355 GLSGNIKFDQNGKRINYTINIMELKTNGPRKIGYWSEVDKMVVTLTELPSGNDTSGLENKTVVVT 419

  Fly   256 SMQDYVSGFSPRNCTFFACSSISAPFV----EADCILGLEMRILGFMKNRLKFDVNQTCSLESR- 315
            ::                   :.:|:|    ..:.:.|.| |..|:..: |..::.:.|..:.:
Human   420 TI-------------------LESPYVMMKKNHEMLEGNE-RYEGYCVD-LAAEIAKHCGFKYKL 463

  Fly   316 --------GEMDGPAN-WTGLLGKVQNNECDFVFGGYYP------DNEVADHFWGSDTYLQDAHT 365
                    |..|.... |.|::|::...:.|....   |      ..||.|.   |..::....:
Human   464 TIVGDGKYGARDADTKIWNGMVGELVYGKADIAIA---PLTITLVREEVIDF---SKPFMSLGIS 522

  Fly   366 WYIKMADR-RPA------------WQALVGIFEAYTWIGFILILIISWLF----WFTLVMILPEP 413
            ..||...: :|.            |..:|     :.:||..::|.:...|    |.|  ....:.
Human   523 IMIKKPQKSKPGVFSFLDPLAYEIWMCIV-----FAYIGVSVVLFLVSRFSPYEWHT--EEFEDG 580

  Fly   414 KYYQQLSLT----AINALAVTISIAVQE----RPICETTRLFFMALTLYGLNVVATYTS------ 464
            :..|....|    ..|:|..::...:|:    .|...:.|:.......:.|.::::||:
Human   581 RETQSSESTNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFL 645

  Fly   465 ---KMIATFQDPGYLHQLDELTEVVAAGIPFGGHEESRDWFEND-----DDMWIF---------- 511
               :|::..:.   ...|.:.||:....:..|   .::::|...     |.||.:
Human   646 TVERMVSPIES---AEDLSKQTEIAYGTLDSG---STKEFFRRSKIAVFDKMWTYMRSAEPSVFV 704

  Fly   512 ----------------NGYNISP---EFIPQSKNLEAVKWGQRCILSNRMYTMQSPLADVIYAFP 557
                            ..|.:..   |:|.|.|..:.:|.|..  |.::.|.:.:|        .
Human   705 RTTAEGVARVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGN--LDSKGYGIATP--------K 759

  Fly   558 NNVFSSPVQMIMKAGFPFLFEMNSIIRLMRDVGIFQKIDADFRYNNTYLNRINKMRPQFPETAIV 622
            .:...:||.:             ::::| .:.|:..|:...:.|:.   ...........|....
Human   760 GSSLRTPVNL-------------AVLKL-SEQGVLDKLKNKWWYDK---GECGAKDSGSKEKTSA 807

  Fly   623 LTTEHLKGPFFILVVGSCWAALTFIGE 649
            |:..::.|.|:|||.|...|.|..:.|
Human   808 LSLSNVAGVFYILVGGLGLAMLVALIE 834

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.