Protein Alignment Ir60a and GRIA1

DIOPT Version :10

• Sequence 1: NP_611901.1
• Gene: Ir60a / 37881
• FlyBaseID: FBgn0034994
• Length: 716
• Species: Drosophila melanogaster
• Sequence 2: NP_001244950.1
• Gene: GRIA1 / 2890
• HGNCID: 4571
• Length: 916
• Species: Homo sapiens
• Alignment Length: 553
• Identity: 99/553 - (17%)
• Similarity: 177/553 - (32%)
• Gaps: 204/553 - (36%)

  Fly    24 IVNLSNETANTVIFMLPEKDLGPDVWKAGVGCLDSFAQIFFFRNPKERFTRAYNLMLVHAFHLSS 88
            :|:..:|..|.::..:.:.:      |.|:|                     |:.:|.:...:..
Human   211 VVDCESERLNAILGQIIKLE------KNGIG---------------------YHYILANLGFMDI 248

  Fly    89 PADQIQE------GFSKLINEAVTNPGPPDREELFQMRVASDY-----------NITNGTEDKGE 136
            ..::.:|      || :|:|...|.|.     ::.|....||.           ..|:.....|.
Human   249 DLNKFKESGANVTGF-QLVNYTDTIPA-----KIMQQWKNSDARDHTRVDWKRPKYTSALTYDGV 307

  Fly   137 LILADNYVIVVDSVDRLKELMKKKIVEMRSWNPGARFLVLFHNATCRNRPLGVASNIFKDLMEMF 201
            .::|:.:          :.|.:::|...|..|.|.   .|.:.|.    |.|...:|.:.|.::.
Human   308 KVMAEAF----------QSLRRQRIDISRRGNAGD---CLANPAV----PWGQGIDIQRALQQVR 355

  Fly   202 YVHRVALLYANS---TMNYNLLVNDYYSNVNCRILNVQSVGQCH-DGKLYPNNAVVKASMQDYVS 262
            :......:..|.   ..||.|.|      :..:...::.:|..: |.|..|.....:|...:
Human   356 FEGLTGNVQFNEKGRRTNYTLHV------IEMKHDGIRKIGYWNEDDKFVPAATDAQAGGDN--- 411

  Fly   263 GFSPRNCTFFACSSISAPFVEADCILGLEMRILGFMKNRLKFDVNQTCSLESRGEMDGPANWTGL 327
             .|.:|.|:...:.:..|:|                  .||.:.||         .:|...:.|.
Human   412 -SSVQNRTYIVTTILEDPYV------------------MLKKNANQ---------FEGNDRYEGY 448

  Fly   328 LGKVQNNECDFVFGGY-YPDNEVADHFWGSDTYLQDAHTWYIKMADRRPAWQALVGIFEAYTWIG 391
            ..::.......|  || |....|:|..:|:    :|..|         .||..:||
Human   449 CVELAAEIAKHV--GYSYRLEIVSDGKYGA----RDPDT---------KAWNGMVG--------- 489

  Fly   392 FILILIISWLFWFTLVMILPEPKYYQQLSLTAINALAVTISIAVQERPICETTRLFFMALTLYGL 456
                   ..::....|.:.|       |::|.:....:..|     :|        ||:|   |:
Human   490 -------ELVYGRADVAVAP-------LTITLVREEVIDFS-----KP--------FMSL---GI 524

  Fly   457 NVVATYTSKMIATFQDPGYLHQLDELTE-----VVAAGI-------------PFGGH----EESR 499
            :::.....|     ..||....||.|..     :|.|.|             |:..|    ||.|
Human   525 SIMIKKPQK-----SKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHSEEFEEGR 584

  Fly   500 DWFEND--DDMWIFN------------GYNISP 518
            |...:|  ::..|||            |.:|||
Human   585 DQTTSDQSNEFGIFNSLWFSLGAFMQQGCDISP 617

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir60a	NP_611901.1	None
GRIA1	NP_001244950.1	PBP1_iGluR_AMPA_GluR1	36..402	CDD:380613	41/246 (17%)
		PBP2_iGluR_AMPA_GluR1	416..797	CDD:270447	56/288 (19%)