Protein Alignment Ir60a and Grik5

DIOPT Version :10

• Sequence 1: NP_611901.1
• Gene: Ir60a / 37881
• FlyBaseID: FBgn0034994
• Length: 716
• Species: Drosophila melanogaster
• Sequence 2: XP_006228444.1
• Gene: Grik5 / 24407
• RGDID: 2735
• Length: 980
• Species: Rattus norvegicus
• Alignment Length: 726
• Identity: 136/726 - (18%)
• Similarity: 235/726 - (32%)
• Gaps: 230/726 - (31%)

  Fly    77 NLMLVHAFHLSSPADQIQEGFSKLIN-------EAVTNPGPPDREELFQMRVASDYNITNGTEDK 134
            |::....|:.|.|   ....|.:.:|       ||.|.|||.                      .
  Rat   263 NILGFSMFNTSHP---FYPEFVRSLNMSWRENCEASTYPGPA----------------------L 302

  Fly   135 GELILADNYVIVVDSVDRLKELMKKKIVEMRSWNPGARFLVLFHNATCRNRPLGVAS-NIFKDLM 198
            ...::.|...:||.:|..|.          ||...|.             :||...| ||:.
  Rat   303 SAALMFDAVHVVVSAVRELN----------RSQEIGV-------------KPLACTSANIWP--- 341

  Fly   199 EMFYVHRVALLYANSTMNYNLLVNDY--------------YSNVNCRILNVQSVGQCHDGKLYPN 249
                       :..|.|||..:| :|              .:|...|||.....|....|..|.|
  Rat   342 -----------HGTSLMNYLRMV-EYDGLTGRVEFNSKGQRTNYTLRILEKSRQGHREIGVWYSN 394

  Fly   250 NAV-VKASMQDYVSGFSPRNCTFFACSSISAPFV----EADCILGLEMRILGFMKNRLKFDVNQT 309
            ..: :.|:..|.....:..|.|....:.:..|:|    ....:.|.| |..||..:.|: ::.:.
  Rat   395 RTLAMNATTLDINLSQTLANKTLVVTTILENPYVMRRPNFQALSGNE-RFEGFCVDMLR-ELAEL 457

  Fly   310 CSLESR---------GEMDGPANWTGLLGKVQNNE-CDFVFGGY--YPDNEVADHFWGSDTYLQD 362
            .....|         |..:...:|||::|::.|.: .|.....:  ..:.|....|......|..
  Rat   458 LRFRYRLRLVEDGLYGAPEPNGSWTGMVGELINRQKADLAVAAFTITAEREKVIDFSKPFMTLGI 522

  Fly   363 AHTWYIKMADRRPAWQALVGIFEAYTWIGFILI--LIISWLF----------WFTLVMILPEPKY 415
            :..:.:.|. |:|.:.:.:..|....|: |:|:  |.:|.:.          |:.....|....:
  Rat   523 SILYRVHMG-RKPGYFSFLDPFSPAVWL-FMLLAYLAVSCVLFLAARLSPYEWYNPHPCLRARPH 585

  Fly   416 YQQLSLTAINALAVTISIAVQE----RPICETTRLFFMALTLYGLNVVATYTSKMIA-----TFQ 471
            ..:...|..|:|...:...:|:    .|...:||........:.|.::::||:.:.|     ..:
  Rat   586 ILENQYTLGNSLWFPVGGFMQQGSEIMPRALSTRCVSGVWWAFTLIIISSYTANLAAFLTVQRME 650

  Fly   472 DPGYLHQLDELTE-------VVAAGIPFGGHEESRDWFENDDDMWIFNGYNISPEFIPQSKNLEA 529
            .|  :...|:|.:       .:.||......:.||  ::....||
  Rat   651 VP--VESADDLADQTNIEYGTIHAGSTMTFFQNSR--YQTYQRMW-------------------- 691

  Fly   530 VKWGQRCILSNRMYTMQSPLADVIYAFPNNVF----SSPVQMIMKAGFPFLFE--MNSIIRLM-- 586
                      |.|.:.|.           :||    ...:..::.:.:.||.|  ||...|.:
  Rat   692 ----------NYMQSKQP-----------SVFVKSTEEGIARVLNSRYAFLLESTMNEYHRRLNC 735

  Fly   587 -----------RDVGIFQKIDADFRYNNTYL-------NRINKMRPQFPE----------TAIVL 623
                       :..||...:.:.||...|..       ||:..::.::.|          .|..|
  Rat   736 NLTQIGGLLDTKGYGIGMPLGSPFRDEITLAILQLQENNRLEILKRKWWEGGRCPKEEDHRAKGL 800

  Fly   624 TTEHLKGPFFILVVGSCWAALTFIGELIIHRWRTQLVSTSEQ--------QDRR----SDKRRRR 676
            ..|::.|.|.:|:.|...|....:.|.|   |.|:..:.||:        |:.|    ..|..|.
  Rat   801 GMENIGGIFVVLICGLIIAVFVAVMEFI---WSTRRSAESEEVSVCQEMLQELRHAVSCRKTSRS 862

  Fly   677 RRRRKPEKDNR 687
            ||||:|...:|
  Rat   863 RRRRRPGGPSR 873

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir60a	NP_611901.1	None
Grik5	XP_006228444.1	PBP1_iGluR_Kainate_KA1_2	23..401	CDD:380616	39/200 (20%)
		Periplasmic_Binding_Protein_Type_2	414..785	CDD:473866	70/419 (17%)