Protein Alignment Ir60a and Grin3a

DIOPT Version :9

• Sequence 1: NP_611901.1
• Gene: Ir60a / 37881
• FlyBaseID: FBgn0034994
• Length: 716
• Species: Drosophila melanogaster
• Sequence 2: NP_001263284.1
• Gene: Grin3a / 242443
• MGIID: 1933206
• Length: 1135
• Species: Mus musculus
• Alignment Length: 574
• Identity: 113/574 - (19%)
• Similarity: 199/574 - (34%)
• Gaps: 142/574 - (24%)

  Fly   235 VQSVGQCHDGKLYPNNAVVKASMQDYVSGFSPRNCTFFACSSISAPFVEADCILGLEMRILGFMK 299
            |...|.|..|:|..:.....:|:.|  |.||..:     .|:.:.|.....|..|..:.:|
Mouse   531 VDDEGLCPAGQLCLDPMTNDSSILD--SLFSSLH-----SSNDTVPIKFKKCCYGYCIDLL---- 584

  Fly   300 NRLKFDVNQTCSLESRGEMDGP------ANWTGLLGKVQNNECDFVFGGYYPD---NEVADHFWG 355
            .:|..|:|....|...|  ||.      .:||||:|.:.:...:.....:..:   ::|.|.
Mouse   585 EQLAEDMNFDFDLYIVG--DGKYGAWKNGHWTGLVGDLLSGTANMAVTSFSINTARSQVIDF--- 644

  Fly   356 SDTYLQDAHTWYIKMADRRPAWQALVGIFEAYTWIGFILILIISWLF-----WFTLVMILPEPKY 415
            :..:...:....::..|......|.:.......|:|..:.|.|:.:|     |.:...:.|:.:.
Mouse   645 TSPFFSTSLGILVRTRDTAAPIGAFMWPLHWTMWLGIFVALHITAIFLTLYEWKSPFGMTPKGRN 709

  Fly   416 YQQL-----SLTAINALAVTISIAVQERPICETTRLFFMALTLYGLNVVATYTSKMIAT------ 469
            ..::     :|....||....:.|::. |.|.|.|.......::.:..::|||:.:.|.
Mouse   710 RNKVFSFSSALNVCYALLFGRTAAIKP-PKCWTGRFLMNLWAIFCMFCLSTYTANLAAVMVGEKI 773

  Fly   470 FQDPGYLHQLDELTEVVAAGIPFGGHEES------RDWFENDDDMWIFNGYNI--SPEFIPQSKN 526
            :::...:|  |......:.|..||...||      |..|....:  ....||:  :|:.:...||
Mouse   774 YEELSGIH--DPKLHHPSQGFRFGTVRESSAEDYVRQSFPEMHE--YMRRYNVPATPDGVQYLKN 834

  Fly   527 ----LEA-----------VKWGQRCILSNRMYTMQSPLADVIYAF---PNNVFSSPVQMIMKAGF 573
                |:|           |.....|    ::.|:..|.|...|..   ||:
Mouse   835 DPEKLDAFIMDKALLDYEVSIDADC----KLLTVGKPFAIEGYGIGLPPNS-------------- 881

  Fly   574 PFLFEMNSIIRLMRDVGIFQKIDADFRYNNTYLNRINKMRPQFPETAIVLTT-----EHLKGPFF 633
            |....::.:|...:..|..     |..::..|     |:.|....:..|..|     :|..|.|.
Mouse   882 PLTSNISELISQYKSHGFM-----DVLHDKWY-----KVVPCGKRSFAVTETLQMGIKHFSGLFV 936

  Fly   634 ILVVGSCWAALTFIGELIIHR--------------W-----------RTQLVSTSE--QQDRRSD 671
            :|.:|...:.||.|||.|::|              |           .|..|...:  .:.:|.:
Mouse   937 LLCIGFGLSILTTIGEHIVYRLLLPRIKNKSKLQYWLHTSQRFHRALNTSFVEEKQPCSKTKRVE 1001

  Fly   672 KRRRRRRRRKPEKD---------NRWQRQVQVAPVVRFTPVKRRK-VFQGQTSQ 715
            |.|.||...|.|.|         |...:|:.|......:...:|| :|..:..|
Mouse  1002 KSRWRRWTCKTEGDSELSLFPRSNMGPQQLMVWNTSNLSHDNQRKYIFNDEEGQ 1055

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir60a	NP_611901.1	None
Grin3a	NP_001263284.1	PBP1_iGluR_NMDA_NR3	30..497	CDD:107372
		PBP2_iGluR_NMDA_Nr3	512..908	CDD:270438	78/420 (19%)
		Lig_chan	676..942	CDD:278489	56/298 (19%)
		PPP2CB binding site. /evidence=ECO:0000250|UniProtKB:Q9R1M7	951..987		6/35 (17%)
		GIT1-binding. /evidence=ECO:0000250|UniProtKB:Q9R1M7	1082..1115

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846514
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.830