DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir60a and Grin3a

DIOPT Version :9

Sequence 1:	NP_611901.1	Gene:	Ir60a / 37881	FlyBaseID:	FBgn0034994	Length:	716	Species:	Drosophila melanogaster
Sequence 2:	NP_612555.1	Gene:	Grin3a / 191573	RGDID:	621704	Length:	1135	Species:	Rattus norvegicus

Alignment Length:	800	Identity:	155/800 - (19%)
Similarity:	269/800 - (33%)	Gaps:	244/800 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 NLSNETANTVIFMLPEKDLGPDVWKAGVGC-LDSFAQIFFFRNPKERFTRAYNLMLVHAFHLSSP 89
            |:.|.|...|:|                || :||..|||      |..|:         |.||.|
  Rat   317 NIRNSTPTMVMF----------------GCDMDSIRQIF------EMSTQ---------FGLSPP 350

  Fly    90 ADQIQEGFSKLINEAVTNPGP------------------PDREELFQMRVAS------------- 123
            ......|.|:.:.|..|...|                  .|..||....||:
  Rat   351 ELHWVLGDSQNVEELRTEGLPLGLIAHGKTTQSVFEYYVQDAMELVARAVATATMIQPELALLPS 415

  Fly   124 -----DYNITNGTED---------------------KGELILA--DNYVIVVDSVDRLKELMKKK 160
                 |...||.|..                     ||..|::  :|:.|.....|.:.:.|..:
  Rat   416 TMNCMDVKTTNLTSGQYLSRFLANTTFRGLSGSIKVKGSTIISSENNFFIWNLQHDPMGKPMWTR 480

  Fly   161 IVEMRSWNPGARFLVLFHNATCRNRPLGVASNIFKDLMEMFYVHRVALLYANSTMNYNLLVNDYY 225
               :.||. |.|.:              :.|.|:.:..:.   |:....:.|. ::..::....:
  Rat   481 ---LGSWQ-GGRIV--------------MDSGIWPEQAQR---HKTHFQHPNK-LHLRVVTLIEH 523

  Fly   226 SNVNCRILNVQSVGQCHDGKLYPNNAVVKASMQDYVSGFSPRNCTFFACSSISAPFVEADCILGL 290
            ..|..|  .|...|.|..|:|..:.....:||.|.:  ||..:     .|:.:.|.....|..|.
  Rat   524 PFVFTR--EVDDEGLCPAGQLCLDPMTNDSSMLDRL--FSSLH-----SSNDTVPIKFKKCCYGY 579

  Fly   291 EMRILGFMKNRLKFDVNQTCSLESRGEMDGP------ANWTGLLGKVQNNECDFVFGGYYPD--- 346
            .:.:|    .:|..|:|....|...|  ||.      .:||||:|.:.:...:.....:..:
  Rat   580 CIDLL----EQLAEDMNFDFDLYIVG--DGKYGAWKNGHWTGLVGDLLSGTANMAVTSFSINTAR 638

  Fly   347 NEVADHFWGSDTYLQDAHTWYIKMADRRPAWQALVGIFEAYTWIGFILILIISWLF-----WFTL 406
            ::|.|.   :..:...:....::..|......|.:.......|:|..:.|.|:.:|     |.:.
  Rat   639 SQVIDF---TSPFFSTSLGILVRTRDTAAPIGAFMWPLHWTMWLGIFVALHITAIFLTLYEWKSP 700

  Fly   407 VMILPEPKYYQQL-----SLTAINALAVTISIAVQERPICETTRLFFMALTLYGLNVVATYTSKM 466
            ..:.|:.:...::     :|....||....:.|::. |.|.|.|.......::.:..::|||:.:
  Rat   701 FGMTPKGRNRNKVFSFSSALNVCYALLFGRTAAIKP-PKCWTGRFLMNLWAIFCMFCLSTYTANL 764

  Fly   467 IAT------FQDPGYLHQLDELTEVVAAGIPFGGHEES------RDWFENDDDMWIFNGYNI--S 517
            .|.      :::...:|  |......:.|..||...||      |..|....:  ....||:  :
  Rat   765 AAVMVGEKIYEELSGIH--DPKLHHPSQGFRFGTVRESSAEDYVRQSFPEMHE--YMRRYNVPAT 825

  Fly   518 PEFIPQSKN----LEA-----------VKWGQRCILSNRMYTMQSPLADVIYAF---PNNVFSSP 564
            |:.:...||    |:|           |.....|    ::.|:..|.|...|..   ||:
  Rat   826 PDGVQYLKNDPEKLDAFIMDKALLDYEVSIDADC----KLLTVGKPFAIEGYGIGLPPNS----- 881

  Fly   565 VQMIMKAGFPFLFEMNSIIRLMRDVGIFQKIDADFRYNNTYLNRINKMRPQFPETAIVLTT---- 625
                     |....::.:|...:..|..     |..::..|     |:.|....:..|..|
  Rat   882 ---------PLTSNISELISQYKSHGFM-----DVLHDKWY-----KVVPCGKRSFAVTETLQMG 927

  Fly   626 -EHLKGPFFILVVGSCWAALTFIGELIIHR--------------WRTQLVSTSEQQDRR-----S 670
             :|..|.|.:|.:|...:.||.|||.|:||              |    :.||::..|.     .
  Rat   928 IKHFSGLFVLLCIGFGLSILTTIGEHIVHRLLLPRIKNKSKLQYW----LHTSQRFHRALNTSFV 988

  Fly   671 DKRRRRRRRRKPEKDNRWQR 690
            ::::.|.:.::.|| :||:|
  Rat   989 EEKQPRSKTKRVEK-SRWRR 1007

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir60a	NP_611901.1	None
Grin3a	NP_612555.1	PBP1_iGluR_NMDA_NR3	30..497	CDD:107372	45/228 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	60..117
		ANF_receptor	127..469	CDD:279440	37/182 (20%)
		PBP2_iGluR_NMDA_Nr3	512..908	CDD:270438	80/442 (18%)
		Lig_chan	676..942	CDD:278489	56/298 (19%)
		PPP2CB binding site	951..987		9/39 (23%)
		GIT1-binding. /evidence=ECO:0000269\|PubMed:24297929	1082..1115
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166350008
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.830