DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir60a and glr-4

DIOPT Version :9

Sequence 1:	NP_611901.1	Gene:	Ir60a / 37881	FlyBaseID:	FBgn0034994	Length:	716	Species:	Drosophila melanogaster
Sequence 2:	NP_001254126.1	Gene:	glr-4 / 174258	WormBaseID:	WBGene00001615	Length:	951	Species:	Caenorhabditis elegans

Alignment Length:	498	Identity:	103/498 - (20%)
Similarity:	179/498 - (35%)	Gaps:	108/498 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   277 ISAPFV--------EADCILGLEMRILGFMKNRLKFDV------NQTCSLESRGEMDGPANWTGL 327
            :..|||        |..||     .:|..|...|||:.      :.|..:|     |....|.|:
Worm   416 LEEPFVIKTGENQYEGFCI-----DLLNEMTQVLKFNYTIIEVQDGTYGIE-----DESGRWNGI 470

  Fly   328 LGKVQNNECDFVFGGY---YPDNEVADH---FWGSDTYLQDAHTWYIKMADRRPAWQALVGIFEA 386
            :|.:|.:|.|......   |...||.|.   |......:..|.|  .:..|:...|..|..: ..
Worm   471 IGALQRHEADLSLSAVTITYSRAEVVDFTLPFMHLGISILLART--SEETDKGSLWTFLEPL-SL 532

  Fly   387 YTWIGFIL-ILIISWLF----------WFTLVMILPEPKYYQQL-----SLTAINALAVTISIAV 435
            ..||..:: ..|:|:..          |:.|..|  :.:.::.:     ..|.:|:...|:...:
Worm   533 TVWISLLISYCIVSYSMHILAKFSPYEWYNLERI--DERDFENIKNQKNQFTVLNSFWFTMGSLM 595

  Fly   436 QER----PICETTRLFFMALTLYGLNVVATYTSKMIATFQDPGYLHQLDELTEVVA------AGI 490
            |:.    |....|||..:...::...::::||:: :|.|.....:....|.|:.:|      .|:
Worm   596 QQGSDVIPRAAATRLIAVVWWMFTQIIISSYTAQ-LAAFLTVERMSTPIESTQDLANQQKIRYGV 659

  Fly   491 PFGGHEESRDWFEND-----DDMWIFNGYNISPEFIPQSK-NLEAVKWGQRCILSNRMYTMQSPL 549
            ...|  .:.|:|...     :.||.....:....|:..|: .:..||.|      ...|.|:|.:
Worm   660 LKSG--STMDFFRESKIPMYERMWSVMESSSPGVFVNSSREGIARVKSG------GYAYMMESSM 716

  Fly   550 ADVIYAFPNNVFSSPVQMIMKAGFPFLFEMNSIIR--LMRDVGIFQKIDADFRYNNTYLNRI-NK 611
            .: .|...:....|...::...|:.......|.:|  |.|.|...|:        .|.|..: ||
Worm   717 LE-YYLERDCELQSIGGLLDSKGYGIALPKGSPLRDILSRTVLQLQE--------RTILEALKNK 772

  Fly   612 M---RPQFP-------ETAIVLTTEHLKGPFFILVVGSCWAALTFIGELII----HRWRTQLVST 662
            .   |.:.|       |.|.....:::.|.|::|:.|...|.|...||..|    ..:|.:|...
Worm   773 WWRDRREGPSCGPPPSEKATNSKPQNIFGIFYVLLTGLIVAFLLACGEYCIESRHEAFRLKLTIV 837

  Fly   663 SEQQD---RRSDKRRRRRRRRKPEKDNRWQRQVQVAPVVRFTP 702
            .:..|   ..|:..::|.:.|..:.|...|   :|:...|..|
Worm   838 GKFMDWYRGNSNDSKQRSKLRNMQLDTAGQ---EVSISTRHDP 877

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir60a	NP_611901.1	None
glr-4	NP_001254126.1	PBP1_iGluR_Kainate	30..385	CDD:107377
		ANF_receptor	45..365	CDD:279440
		Periplasmic_Binding_Protein_Type_2	410..775	CDD:304360	79/391 (20%)
		Lig_chan	533..810	CDD:278489	56/296 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910