Protein Alignment Ir60a and Grin3b

DIOPT Version :10

• Sequence 1: NP_611901.1
• Gene: Ir60a / 37881
• FlyBaseID: FBgn0034994
• Length: 716
• Species: Drosophila melanogaster
• Sequence 2: NP_579842.2
• Gene: Grin3b / 170796
• RGDID: 621705
• Length: 1002
• Species: Rattus norvegicus
• Alignment Length: 558
• Identity: 111/558 - (19%)
• Similarity: 181/558 - (32%)
• Gaps: 154/558 - (27%)

  Fly   239 GQCHDGKL-----YPNNAVVKASMQDYVSGFSP---RNCTFFACSSISAPFVEADCILGLEMRIL 295
            |||..|:|     ..::|.:.|.....|:|..|   |.|.:..|..:.....| |.....|:.|:
  Rat   437 GQCPAGQLCLDPGTNDSARLDALFAALVNGSVPRTLRRCCYGYCIDLLERLAE-DLAFDFELYIV 500

  Fly   296 GFMK-NRLKFDVNQTCSLESRGEMDGPANWTGLLGKVQNNECDFVFGGYYPD---NEVADH---F 353
            |..| ..|:               ||  .||||:|.:...........:..:   ::|.|.   |
  Rat   501 GDGKYGALR---------------DG--RWTGLVGDLLAGRAHMAVTSFSINSARSQVVDFTSPF 548

  Fly   354 WGSDTYLQ----------DAHTWYIKMADRRPAWQALVGIFEAYTWIGFILILIISWLFWFTLVM 408
            :.:...:.          .|..|.:.       |...||:|.|.    .:..|.::...|.:...
  Rat   549 FSTSLGIMVRTRDTASPIGAFMWPLH-------WSMWVGVFAAL----HLTALFLTLYEWRSPYG 602

  Fly   409 ILPEPK-------YYQQLSLTAINALAVTISIAVQERPICETTRLFFMALTLYGLNVVATYTSKM 466
            :.|..:       |...|:|........|:|   .:.|.|.|.|.......::.|.|:::||:.:
  Rat   603 LTPRGRNRGTVFSYSSALNLCYAILFGRTVS---SKTPKCPTGRFLMNLWAIFCLLVLSSYTANL 664

  Fly   467 IA------TFQDPGYLHQLDELTEVVAAGIPFGGHEESRDWFENDDDMWIFNGYNISPEFIPQSK 525
            .|      ||::...:|  |......:.|..||     ..| |:..:.:|...:   ||.....:
  Rat   665 AAVMVGDKTFEELSGIH--DPKLHHPSQGFRFG-----TVW-ESSAEAYIKASF---PEMHAHMR 718

  Fly   526 NLEA--VKWGQRCILSN----RMYTMQSPLADVIYAFPNNVFSSPVQMIMKAGFPFLFE------ 578
            ...|  ...|...:.|:    ..:.|...|.|...:...:.      .::..|.||..|
  Rat   719 RHSAPTTPHGVAMLTSDPPKLNAFIMDKSLLDYEVSIDADC------KLLTVGKPFAIEGYGIGL 777

  Fly   579 ---------MNSIIRLMRDVGIFQKIDADFRYNNTYLNRINKMRPQFPETAIVLTT-----EHLK 629
                     ::..|...:..|..     |..::..|     ||.|.......|..|     .|..
  Rat   778 PQNSPLTSNLSEFISRYKSSGFI-----DLLHDKWY-----KMVPCGKRVFAVTETLQMGVYHFS 832

  Fly   630 GPFFILVVGSCWAALTFIGELIIHR--------------W--------RTQLVSTSEQQDRRSDK 672
            |.|.:|.:|...|.||.:||.:.:|              |        |.......|.|..|:::
  Rat   833 GLFVLLCLGLGSALLTSLGEHVFYRLVLPRIRRGNKLQYWLHTSQKIHRALNTGPPEGQQERAEQ 897

  Fly   673 RRRRRRRRKPEKD--NRWQRQVQVAPVVRFTPVKRRKV 708
            .|...:...|..|  .||:|       ||....:.|:|
  Rat   898 ERSGPKDELPATDGAGRWRR-------VRRAVERERRV 928

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir60a	NP_611901.1	None
Grin3b	NP_579842.2	PBP1_iGluR_NMDA_NR3	19..401	CDD:380600
		PBP2_iGluR_NMDA_Nr3	414..808	CDD:270438	79/424 (19%)
		Lig_chan	574..841	CDD:459656	57/307 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	882..910		5/27 (19%)
		Involved in the trafficking and surface expression of NMDARs. /evidence=ECO:0000250|UniProtKB:Q91ZU9	951..984