DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir60a and Grin3b

DIOPT Version :9

Sequence 1:	NP_611901.1	Gene:	Ir60a / 37881	FlyBaseID:	FBgn0034994	Length:	716	Species:	Drosophila melanogaster
Sequence 2:	XP_006513350.1	Gene:	Grin3b / 170483	MGIID:	2150393	Length:	1138	Species:	Mus musculus

Alignment Length:	512	Identity:	104/512 - (20%)
Similarity:	168/512 - (32%)	Gaps:	143/512 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   239 GQCHDGKL-----YPNNAVVKASMQDYVSGFSP---RNCTFFACSSISAPFVEADCILGLEMRIL 295
            |||..|:|     ..::|.:.|......:|..|   |.|.:..|..:.....| |.....|:.|:
Mouse   517 GQCPAGQLCLDPGTNDSARLDALFTALENGSVPRTLRRCCYGYCIDLLERLAE-DLAFDFELYIV 580

  Fly   296 GFMK-NRLKFDVNQTCSLESRGEMDGPANWTGLLGKVQNNECDFVFGGYYPD---NEVADH---F 353
            |..| ..|:               ||  .||||:|.:...........:..:   ::|.|.   |
Mouse   581 GDGKYGALR---------------DG--RWTGLVGDLLAGRAHMAVTSFSINSARSQVVDFTSPF 628

  Fly   354 WGSDTYLQ----------DAHTWYIKMADRRPAWQALVGIFEAYTWIGFILILIISWLFWFTLVM 408
            :.:...:.          .|..|.:.       |...||:|.|.    .:..|.::...|.:...
Mouse   629 FSTSLGIMVRTRDTASPIGAFMWPLH-------WSMWVGVFAAL----HLTALFLTLYEWRSPYG 682

  Fly   409 ILPEPK-------YYQQLSLTAINALAVTISIAVQERPICETTRLFFMALTLYGLNVVATYTSKM 466
            :.|..:       |...|:|........|:|   .:.|.|.|.|.......::.|.|:::||:.:
Mouse   683 LTPRGRNRGTVFSYSSALNLCYAILFGRTVS---SKTPKCPTGRFLMNLWAIFCLLVLSSYTANL 744

  Fly   467 IA------TFQDPGYLHQLDELTEVVAAGIPFGGHEESRDWFENDDDMWIFNGYNISPEFIPQSK 525
            .|      ||::...:|  |......:.|..||     ..| |:..:.:|...:   ||.....:
Mouse   745 AAVMVGDKTFEELSGIH--DPKLHHPSQGFRFG-----TVW-ESSAEAYIKASF---PEMHAHMR 798

  Fly   526 NLEA--VKWGQRCILSN----RMYTMQSPLADVIYAFPNNVFSSPVQMIMKAGFPFLFE------ 578
            ...|  ...|...:.|:    ..:.|...|.|...:...:.      .::..|.||..|
Mouse   799 RHSAPTTPHGVAMLTSDPPKLNAFIMDKSLLDYEVSIDADC------KLLTVGKPFAIEGYGIGL 857

  Fly   579 ---------MNSIIRLMRDVGIFQKIDADFRYNNTYLNRINKMRPQFPETAIVLTT-----EHLK 629
                     ::..|...:..|..     |..::..|     ||.|.......|..|     .||.
Mouse   858 PQNSPLTSNLSEFISRYKSSGFI-----DLLHDKWY-----KMVPCGKRVFAVTETLQMGVYHLS 912

  Fly   630 GPFFILVVGSCWAALTFIGELIIHR--------------WRTQLVSTSEQQDRRSDK 672
            |.|.:|.:|...|.||.:||.:.:|              |    :.||  |.||.||
Mouse   913 GLFVLLCLGLGSALLTSLGEHVFYRLVLPRIRRGNKLQYW----LHTS--QVRRQDK 963

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir60a	NP_611901.1	None
Grin3b	XP_006513350.1	PBP1_iGluR_NMDA_NR3	141..481	CDD:380600
		PBP2_iGluR_NMDA_Nr3	494..888	CDD:270438	78/424 (18%)
		Lig_chan	656..922	CDD:365843	57/299 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846579
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.830