DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir60a and gria3a

DIOPT Version :9

Sequence 1:	NP_611901.1	Gene:	Ir60a / 37881	FlyBaseID:	FBgn0034994	Length:	716	Species:	Drosophila melanogaster
Sequence 2:	XP_005165152.1	Gene:	gria3a / 170452	ZFINID:	ZDB-GENE-020125-5	Length:	903	Species:	Danio rerio

Alignment Length:	762	Identity:	118/762 - (15%)
Similarity:	234/762 - (30%)	Gaps:	275/762 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    73 TRAYNLMLVHAFHLSSPADQIQEGFSKLINEAVTNPGPP------------DREELFQMRVASDY 125
            :|.|:.:|.:....:...|::..|.:.:....:.||..|            |..|..:.| :|..
Zfish   233 SRGYHYILANLGFTNMSLDKVFSGGANITGFQIINPDSPIVQQFLQRWERLDEREFPESR-SSPL 296

  Fly   126 NITNGTEDKGELILADNYVIVVDSVDRLKELMKKKI-VEMRS------------WNPG-----AR 172
            ..|:.......|::|:.:          :.|.:::: :..|.            |:.|     |.
Zfish   297 KYTSALTHDAILVIAEAF----------RYLRRQRVDISRRGSAGDCLANPAVPWSQGIDIERAL 351

  Fly   173 FLVLFHNAT--CRNRPLGVASNIFKDLMEMFYVHRVALLYANSTMNYNLLVNDYYSNVNCRILNV 235
            .:|.....|  .:....|..||...|:.||.......:.|.|....:..:|....:|
Zfish   352 KMVQVQGMTGNIQFDSFGRRSNYTVDVYEMKPGGARKIGYWNEFEKFVYIVEQQVTN-------- 408

  Fly   236 QSVGQCHDGKLYPNNAVVKASMQDYVSGFSPRNCTFFACSSISAPFV---------------EAD 285
                                      ...|..|.|....:.:.||:|               |..
Zfish   409 --------------------------ESSSVENRTIVVTTIMEAPYVMYKRNYMQLEGNDRYEGY 447

  Fly   286 CI-LGLEMRILGFMKNRLKFDVNQTCSLESRGEMDG----PANWTGLLGKVQNNECDFVFGGYYP 345
            |: |..|:.....:|.:|        |:.:.|:...    ...|.|::|::.....|....   |
Zfish   448 CVDLASEIAKHVGIKYKL--------SIVADGKYGARDPETKTWNGMVGELVYGRADIAVA---P 501

  Fly   346 ------DNEVADHFWGSDTYLQDAHTWYIKMADR-RPA------------WQALVGIFEAYTWIG 391
                  ..||.|.   |..::....:..||...: :|.            |..:|     :.:||
Zfish   502 LTITLVREEVIDF---SKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIV-----FAYIG 558

  Fly   392 FILILIISWLF----WFTLVMIL------------PEPKYYQQLSLTAINALAVTISIAVQE--- 437
            ..::|.:...|    |.     |            |:|..    .....|:|..::...:|:
Zfish   559 VSVVLFLVSRFSPYEWH-----LDDNEETKDPQTPPDPPN----DFGIFNSLWFSLGAFMQQGCD 614

  Fly   438 -RPICETTRLFFMALTLYGLNVVATYTS---------KMIATFQDPGYLHQLDELTEVVAAGIPF 492
             .|...:.|:.......:.|.::::||:         :|::..:.   ...|.:.||:....:..
Zfish   615 ISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIES---AEDLAKQTEIAYGTLDS 676

  Fly   493 GGHEESRDWFEND-----DDMWIF--------------NGY---------------NISPEFIPQ 523
            |   .::::|...     :.||.:              :|.               :...|:|.|
Zfish   677 G---STKEFFRRSKIAVYEKMWSYMKSAEPSVFVKTTPDGVARVRKSKGKFAFLLESTMNEYIEQ 738

  Fly   524 SKNLEAVKWGQRCILSNRMYTMQSPLADVIYAFPNNVFSSPVQMIMKAGFPFLFEMNSIIRLMRD 588
            .|..:.:|.|..  |.::.|.:.:|        ..:...:||.:             ::::| .:
Zfish   739 RKPCDTMKVGGN--LDSKGYGVATP--------KGSALRTPVNL-------------AVLKL-SE 779

  Fly   589 VGIFQKIDADFRYNN----------------------TYLNRINKMRPQFPETAIVLTTEHLKGP 631
            .||..|:...:.|:.                      |.::..:|...:||.......     .|
Zfish   780 QGILDKLKNKWWYDKGECGTKDSGSKVSLLTHLTVLPTNISIYHKHHNEFPVAGFTFF-----WP 839

  Fly   632 FFILVVGSCWAALTFIGELIIHR--WRTQLVSTSEQQDRRSDKRRRR 676
            .|||.  :|       .:.|:|.  .::|.::...|.:|.:...|||
Zfish   840 LFILF--TC-------AQAIMHHVVRKSQPLALMRQHNRCTHSHRRR 877

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir60a	NP_611901.1	None
gria3a	XP_005165152.1	PBP1_iGluR_AMPA_GluR3	28..399	CDD:107382	30/176 (17%)
		ANF_receptor	39..382	CDD:279440	27/159 (17%)
		PBP2_iGluR_AMPA	415..797	CDD:270433	68/439 (15%)
		Lig_chan	547..810	CDD:278489	43/306 (14%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591650
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.830