Protein Alignment Ir60a and gria2b

DIOPT Version :10

• Sequence 1: NP_611901.1
• Gene: Ir60a / 37881
• FlyBaseID: FBgn0034994
• Length: 716
• Species: Drosophila melanogaster
• Sequence 2: XP_068069253.1
• Gene: gria2b / 170451
• ZFINID: ZDB-GENE-020125-4
• Length: 944
• Species: Danio rerio
• Alignment Length: 802
• Identity: 132/802 - (16%)
• Similarity: 253/802 - (31%)
• Gaps: 270/802 - (33%)

  Fly    71 RFTRAYNLMLVHAFHLSSPADQIQEGFSKLINEAVTNPGPPDREELFQMRVASDYNITNGTEDKG 135
            |..:.|:.::.:...:.....:||.|.:.:....:.:...|...:..|...|.:.....|.:.|.
Zfish   227 RHVKGYHYIIANLGFVDGDLSKIQYGGANVSGFQIVDFDDPLVSKFDQRWEALEEKEYPGADSKI 291

  Fly   136 ELILADNYVIVVDSVDRLKELMKKKI-VEMRS------------WNPGARFLVLFHNATCRNRPL 187
            ....|..|..|....:..:.|.|::| :..|:            |..|    |....|..:.|..
Zfish   292 RYTSALTYDAVQVMTEAFRYLHKQRIDISRRANNGDCLANPAVPWAQG----VEIERALKQVRVD 352

  Fly   188 GVASNIFKDLMEMFYVHRVALLYANSTMNYNLLVND------YYSNVNCRILNVQSVGQCHDGKL 246
            |:..||..|.    |..||     |.|:|...|.::      |::.|:..::.        ...|
Zfish   353 GLTGNIQFDQ----YGKRV-----NYTVNVMELKSNGAVKIGYWNEVDKMVVT--------KSDL 400

  Fly   247 YPNNAVVKASMQDYVSGFSPRNCTFFACSSISAPFV----EADCILGLEMRILGFMKNRLKFDVN 307
            :||:.:            ...|.|....:.:.||:|    .||..:..| |..|:..: |..::.
Zfish   401 FPNDTM------------GLENKTVIVTTILEAPYVMLKKNADLFMDNE-RYEGYCVD-LAAEIA 451

  Fly   308 QTCSLESRGEMDGPAN----------WTGLLGKVQNNECDFVFGGYYP------DNEVADHFWGS 356
            :.|..:.:.::.|...          |.|::|::...:.|....   |      ..||.|.   |
Zfish   452 KHCGFKYQLKIVGDGKYGARDAETKIWNGMVGELVYGKADIAVA---PLTITLVREEVIDF---S 510

  Fly   357 DTYLQDAHTWYIKMADR-RPA------------WQALVGIFEAYTWIGFILILIISWLF----WF 404
            ..::....:..||...: :|.            |..:|     :.:||..::|.:...|    |.
Zfish   511 KPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIV-----FAYIGVSVVLFLVSRFSPYEWH 570

  Fly   405 TLVMILPEPKYYQQLSLTA---------INALAVTISIAVQERPICETT------RLFFMALTLY 454
            |        :.|:...:..         .|:|  ..|:....|..|:.:      |:.......:
Zfish   571 T--------EEYEDGQIQTNESTNEFGIFNSL--WFSLGAFMRQGCDISPRSLSGRIVGGVWWFF 625

  Fly   455 GLNVVATYTS---------KMIATFQDPGYLHQLDELTEVVAAGIPFGGHEESRDWFEND----- 505
            .|.::::||:         :|::..:.   ...|.:.||:....:..|   .::::|...
Zfish   626 TLIIISSYTANLAAFLTVERMVSPIES---AEDLAKQTEIAYGTLDSG---STKEFFRRSKIALF 684

  Fly   506 DDMWIF-NGYNIS----------------------------PEFIPQSKNLEAVKWGQRCILSNR 541
            |.||.: .|...|                            .|:|.|.|..:.:|.|..  |.::
Zfish   685 DKMWTYMKGAEPSVFVKTTAEGVMRVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGN--LDSK 747

  Fly   542 MYTMQSPLADVIYAFPNNVFSSPVQMIMKAGFPFLFEMNSIIRLMRDVGIFQKIDADFRY----- 601
            .|.:.:|                      .|......:|..:..:.:.|:..|:...:.|
Zfish   748 GYGIATP----------------------KGSSLRNAVNLAVLKLNEQGLLDKLKNKWWYDKGEC 790

  Fly   602 ---------------NNTYLN----------RINKMRPQF--------------PETAIVLTTEH 627
                           :.|.:|          .::|::.::              .|....|:..:
Zfish   791 GSGGGDSKVSPREQSDGTPVNLAVLKLSEQGTLDKLKNKWWYDKGECGAKDSGSKEKTSALSLSN 855

  Fly   628 LKGPFFILVVGSCWAALTFIGELIIHRWRTQLVSTSEQQDRR---SDKRRRRRRR---------- 679
            :.|.|:|||.|...|.|..:.|....       |.:|.:..:   ||..|.:.|.
Zfish   856 VAGVFYILVGGLGLAMLVALVEFCYK-------SRAEAKRMKVTFSDAMRSKARLSVTGSTGENG 913

  Fly   680 --RKPEKDNRWQRQVQVAPVVR 699
              ..||    :.:.|...|.||
Zfish   914 RVMSPE----FPKAVHAVPFVR 931

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir60a	NP_611901.1	None
gria2b	XP_068069253.1	PBP1_iGluR_AMPA_GluR2	27..397	CDD:380612	35/190 (18%)
		PBP2_iGluR_AMPA	410..790	CDD:270433	68/432 (16%)