Protein Alignment Ir60a and Gria2

DIOPT Version :10

• Sequence 1: NP_611901.1
• Gene: Ir60a / 37881
• FlyBaseID: FBgn0034994
• Length: 716
• Species: Drosophila melanogaster
• Sequence 2: NP_001344853.2
• Gene: Gria2 / 14800
• MGIID: 95809
• Length: 901
• Species: Mus musculus
• Alignment Length: 612
• Identity: 102/612 - (16%)
• Similarity: 204/612 - (33%)
• Gaps: 183/612 - (29%)

  Fly   143 YVIVVDSVDRLKELMKKKIVEMRSWNPGARFLVLFHNATCRNRPLGVASNIFKDLMEMFYVHRVA 207
            |..|....:..:.|.|::|...|..|.|.   .|.:.|.    |.|....|.:.|.::    :|.
Mouse   301 YDAVQVMTEAFRNLRKQRIEISRRGNAGD---CLANPAV----PWGQGVEIERALKQV----QVE 354

  Fly   208 LLYAN-------STMNYNLLVND----------YYSNVNCRILNVQSVGQCHDGKLYPNNAVVKA 255
            .|..|       ..:||.:.:.:          |:|.|:..::.:..:...:|.....|..||..
Mouse   355 GLSGNIKFDQNGKRINYTINIMELKTNGPRKIGYWSEVDKMVVTLTELPSGNDTSGLENKTVVVT 419

  Fly   256 SMQDYVSGFSPRNCTFFACSSISAPFV----EADCILGLEMRILGFMKNRLKFDVNQTCSLESR- 315
            ::                   :.:|:|    ..:.:.|.| |..|:..: |..::.:.|..:.:
Mouse   420 TI-------------------LESPYVMMKKNHEMLEGNE-RYEGYCVD-LAAEIAKHCGFKYKL 463

  Fly   316 --------GEMDGPAN-WTGLLGKVQNNECDFVFGGYYP------DNEVADHFWGSDTYLQDAHT 365
                    |..|.... |.|::|::...:.|....   |      ..||.|.   |..::....:
Mouse   464 TIVGDGKYGARDADTKIWNGMVGELVYGKADIAIA---PLTITLVREEVIDF---SKPFMSLGIS 522

  Fly   366 WYIKMADR-RPA------------WQALVGIFEAYTWIGFILILIISWLF----WFTLVMILPEP 413
            ..||...: :|.            |..:|     :.:||..::|.:...|    |.|  ....:.
Mouse   523 IMIKKPQKSKPGVFSFLDPLAYEIWMCIV-----FAYIGVSVVLFLVSRFSPYEWHT--EEFEDG 580

  Fly   414 KYYQQLSLT----AINALAVTISIAVQE----RPICETTRLFFMALTLYGLNVVATYTS------ 464
            :..|....|    ..|:|..::...:|:    .|...:.|:.......:.|.::::||:
Mouse   581 RETQSSESTNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFL 645

  Fly   465 ---KMIATFQDPGYLHQLDELTEVVAAGIPFGGHEESRDWFEND-----DDMWIF---------- 511
               :|::..:.   ...|.:.||:....:..|   .::::|...     |.||.:
Mouse   646 TVERMVSPIES---AEDLSKQTEIAYGTLDSG---STKEFFRRSKIAVFDKMWTYMRSAEPSVFV 704

  Fly   512 ----------------NGYNISP---EFIPQSKNLEAVKWGQRCILSNRMYTMQSPLADVIYAFP 557
                            ..|.:..   |:|.|.|..:.:|.|..  |.::.|.:.:|        .
Mouse   705 RTTAEGVARVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGN--LDSKGYGIATP--------K 759

  Fly   558 NNVFSSPVQMIMKAGFPFLFEMNSIIRLMRDVGIFQKIDADFRYNNTYLNRINKMRPQFPETAIV 622
            .:...:||.:             ::::| .:.|:..|:...:.|:.   ...........|....
Mouse   760 GSSLRTPVNL-------------AVLKL-SEQGVLDKLKNKWWYDK---GECGAKDSGSKEKTSA 807

  Fly   623 LTTEHLKGPFFILVVGSCWAALTFIGE 649
            |:..::.|.|:|||.|...|.|..:.|
Mouse   808 LSLSNVAGVFYILVGGLGLAMLVALIE 834

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir60a	NP_611901.1	None
Gria2	NP_001344853.2	PBP1_iGluR_AMPA_GluR2	28..398	CDD:380612	22/107 (21%)
		PBP2_iGluR_AMPA	413..794	CDD:270433	68/447 (15%)