Protein Alignment Ir60a and Gria1

DIOPT Version :10

• Sequence 1: NP_611901.1
• Gene: Ir60a / 37881
• FlyBaseID: FBgn0034994
• Length: 716
• Species: Drosophila melanogaster
• Sequence 2: NP_032191.2
• Gene: Gria1 / 14799
• MGIID: 95808
• Length: 907
• Species: Mus musculus
• Alignment Length: 542
• Identity: 99/542 - (18%)
• Similarity: 176/542 - (32%)
• Gaps: 182/542 - (33%)

  Fly    24 IVNLSNETANTVIFMLPEKDLGPDVWKAGVGCLDSFAQIFFFRNPKERFTRAYNLMLVHAFHLSS 88
            :|:..:|..|.::..:.:.:      |.|:|                     |:.:|.:...:..
Mouse   201 VVDCESERLNAILGQIVKLE------KNGIG---------------------YHYILANLGFMDI 238

  Fly    89 PADQIQE------GFSKLINEAVTNPGPPDREELFQMRVASDYNITNGTEDKGELILADNYVIVV 147
            ..::.:|      || :|:|...|.|.    ..:.|.|.:...:.|.....:.:...|..|..|.
Mouse   239 DLNKFKESGANVTGF-QLVNYTDTIPA----RIMQQWRTSDARDHTRVDWKRPKYTSALTYDGVK 298

  Fly   148 DSVDRLKELMKKKIVEMRSWNPGARFLVLFHNATCRNRPLGVASNIFKDLMEMFYVHRVALLYAN 212
            ...:..:.|.:::|...|..|.|.   .|.:.|.    |.|...:|.:.|.::.:......:..|
Mouse   299 VMAEAFQSLRRQRIDISRRGNAGD---CLANPAV----PWGQGIDIQRALQQVRFEGLTGNVQFN 356

  Fly   213 S---TMNYNLLVNDYYSNVNCRILNVQSVGQCH-DGKLYPNNAVVKASMQDYVSGFSPRNCTFFA 273
            .   ..||.|.|      :..:...::.:|..: |.|..|.....:|...:    .|.:|.|:..
Mouse   357 EKGRRTNYTLHV------IEMKHDGIRKIGYWNEDDKFVPAATDAQAGGDN----SSVQNRTYIV 411

  Fly   274 CSSISAPFVEADCILGLEMRILGFMKNRLKFDVNQTCSLESRGEMDGPANWTGLLGKVQNNECDF 338
            .:.:..|:|                  .||.:.||         .:|...:.|...::.......
Mouse   412 TTILEDPYV------------------MLKKNANQ---------FEGNDRYEGYCVELAAEIAKH 449

  Fly   339 VFGGY-YPDNEVADHFWGSDTYLQDAHTWYIKMADRRPAWQALVGIFEAYTWIGFILILIISWLF 402
            |  || |....|:|..:|:    :|..|         .||..:||                ..::
Mouse   450 V--GYSYRLEIVSDGKYGA----RDPDT---------KAWNGMVG----------------ELVY 483

  Fly   403 WFTLVMILPEPKYYQQLSLTAINALAVTISIAVQERPICETTRLFFMALTLYGLNVVATYTSKMI 467
            ....|.:.|       |::|.:....:..|     :|        ||:|   |::::.....|
Mouse   484 GRADVAVAP-------LTITLVREEVIDFS-----KP--------FMSL---GISIMIKKPQK-- 523

  Fly   468 ATFQDPGYLHQLDELTE-----VVAAGI-------------PFGGH----EESRDWFEND--DDM 508
               ..||....||.|..     :|.|.|             |:..|    ||.||...:|  ::.
Mouse   524 ---SKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHSEEFEEGRDQTTSDQSNEF 585

  Fly   509 WIFN------------GYNISP 518
            .|||            |.:|||
Mouse   586 GIFNSLWFSLGAFMQQGCDISP 607

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir60a	NP_611901.1	None
Gria1	NP_032191.2	PBP1_iGluR_AMPA_GluR1	26..392	CDD:380613	41/235 (17%)
		PBP2_iGluR_AMPA_GluR1	406..787	CDD:270447	56/288 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	857..881
		PDZ-binding	904..907