DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir60a and GRIN3A

DIOPT Version :9

Sequence 1:	NP_611901.1	Gene:	Ir60a / 37881	FlyBaseID:	FBgn0034994	Length:	716	Species:	Drosophila melanogaster
Sequence 2:	NP_597702.2	Gene:	GRIN3A / 116443	HGNCID:	16767	Length:	1115	Species:	Homo sapiens

Alignment Length:	822	Identity:	150/822 - (18%)
Similarity:	264/822 - (32%)	Gaps:	265/822 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    84 FHLSSPADQIQEGFSKLINEAVTNPGPPDREELFQMRVASDYNITNGTEDKGELILADNYVIV-- 146
            |||.|           :||.....|...|.....|:::.|   |.|.|..          |::
Human   289 FHLGS-----------IINITANLPSTQDLLSFLQIQLES---IKNSTPT----------VVMFG 329

  Fly   147 --VDSVDRLKELM----------------KKKIVEMRSWNPGARFLVLFHNATCRNRPLGVASNI 193
              ::|:.|:.|:.                .:.:.|:|:  .|....::.|..|.::    |..:.
Human   330 CDMESIRRIFEITTQFGVMPPELRWVLGDSQNVEELRT--EGLPLGLIAHGKTTQS----VFEHY 388

  Fly   194 FKDLMEMFYVHRVA--------LLYANSTMN------YNLLVNDYYSNV---------------- 228
            .:|.||: ....||        |....||||      .||....|.|..
Human   389 VQDAMEL-VARAVATATMIQPELALIPSTMNCMEVETTNLTSGQYLSRFLANTTFRGLSGSIRVK 452

  Fly   229 ---------NCRILNVQ----------SVGQCHDGKLYPNNAVVKASMQDYVSGFS-PRNCTFFA 273
                     |..|.|:|          .:|....||:..:..:.....|.:.:.|. |.......
Human   453 GSTIVSSENNFFIWNLQHDPMGKPMWTRLGSWQGGKIVMDYGIWPEQAQRHKTHFQHPSKLHLRV 517

  Fly   274 CSSISAPFV---EAD------------------------------------------CILGLEMR 293
            .:.|..|||   |.|                                          |..|..:.
Human   518 VTLIEHPFVFTREVDDEGLCPAGQLCLDPMTNDSSTLDSLFSSLHSSNDTVPIKFKKCCYGYCID 582

  Fly   294 ILGFMKNRLKFDVNQTCSLESRGEMDGP------ANWTGLLGKVQNNECDFVFGGYYPD---NEV 349
            :|    .::..|:|....|...|  ||.      .:||||:|.:...........:..:   ::|
Human   583 LL----EKIAEDMNFDFDLYIVG--DGKYGAWKNGHWTGLVGDLLRGTAHMAVTSFSINTARSQV 641

  Fly   350 ADHFWGSDTYLQDAHTWYIKMADRRPAWQALVGIFEAYTWIGFILILIISWLF-----WFTLVMI 409
            .|.   :..:...:....::..|......|.:.......|:|..:.|.|:.:|     |.:...:
Human   642 IDF---TSPFFSTSLGILVRTRDTAAPIGAFMWPLHWTMWLGIFVALHITAVFLTLYEWKSPFGL 703

  Fly   410 LPEPKYYQQL-----SLTAINALAVTISIAVQERPICETTRLFFMALTLYGLNVVATYTSKMIAT 469
            .|:.:...::     :|....||....::|::. |.|.|.|.......::.:..::|||:.:.|.
Human   704 TPKGRNRSKVFSFSSALNICYALLFGRTVAIKP-PKCWTGRFLMNLWAIFCMFCLSTYTANLAAV 767

  Fly   470 ------FQDPGYLHQLDELTEVVAAGIPFGGHEES------RDWFENDDDMWIFNGYNI--SPEF 520
                  :::...:|  |......:.|..||...||      |..|....:  ....||:  :|:.
Human   768 MVGEKIYEELSGIH--DPKLHHPSQGFRFGTVRESSAEDYVRQSFPEMHE--YMRRYNVPATPDG 828

  Fly   521 IPQSKN----LEA-----------VKWGQRCILSNRMYTMQSPLADVIYAF---PNNVFSSPVQM 567
            :...||    |:|           |.....|    ::.|:..|.|...|..   ||:
Human   829 VEYLKNDPEKLDAFIMDKALLDYEVSIDADC----KLLTVGKPFAIEGYGIGLPPNS-------- 881

  Fly   568 IMKAGFPFLFEMNSIIRLMRDVGIFQKIDADFRYNNTYLNRI---NKMRPQFPETAIVLTTEHLK 629
                  |....::.:|...:..|..     |..::..|  |:   .|......|| :.:..:|..
Human   882 ------PLTANISELISQYKSHGFM-----DMLHDKWY--RVVPCGKRSFAVTET-LQMGIKHFS 932

  Fly   630 GPFFILVVGSCWAALTFIGELIIHR--------------WRTQLVSTSEQQDRR------SDKRR 674
            |.|.:|.:|...:.||.|||.|::|              |    :.||::..|.      .:|::
Human   933 GLFVLLCIGFGLSILTTIGEHIVYRLLLPRIKNKSKLQYW----LHTSQRLHRAINTSFIEEKQQ 993

  Fly   675 RRRRRRKPEKDNRWQRQVQVAPVVRFTPVKRRK-VFQGQTSQ 715
            ..:.:|..::.|...||:.|......:...||| :|..:..|
Human   994 HFKTKRVEKRSNVGPRQLTVWNTSNLSHDNRRKYIFSDEEGQ 1035

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir60a	NP_611901.1	None
GRIN3A	NP_597702.2	PBP1_iGluR_NMDA_NR3	30..497	CDD:107372	44/238 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	59..118
		ANF_receptor	127..469	CDD:279440	40/210 (19%)
		PBP2_iGluR_NMDA_Nr3	512..908	CDD:270438	71/432 (16%)
		Lig_chan	676..942	CDD:278489	56/296 (19%)
		PPP2CB binding site. /evidence=ECO:0000250	951..987		8/39 (21%)
		GIT1-binding. /evidence=ECO:0000250\|UniProtKB:Q9R1M7	1062..1095
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156086
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.830