DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir60a and grin3bb

DIOPT Version :9

Sequence 1:	NP_611901.1	Gene:	Ir60a / 37881	FlyBaseID:	FBgn0034994	Length:	716	Species:	Drosophila melanogaster
Sequence 2:	XP_017213803.2	Gene:	grin3bb / 100333101	ZFINID:	ZDB-GENE-131122-77	Length:	1114	Species:	Danio rerio

Alignment Length:	731	Identity:	151/731 - (20%)
Similarity:	243/731 - (33%)	Gaps:	194/731 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    84 FHLSSPADQIQEGFSKLINEAVT--NPGPPDREELFQMRVASDYNITN--GTEDKGELILADNY- 143
            |::|   |.:|     |||.|||  ....||        :|...|:.|  ...:|.||..:..|
Zfish   314 FYIS---DALQ-----LINRAVTAATVVRPD--------LALIQNMVNCFDKPNKHELPSSGQYI 362

  Fly   144 ---------------VIVVDSVDRLKELMKKKIVEMR-------------SWNPGARFLV----L 176
                           |||..::.|:....|..|..:|             ||. |.|..|    |
Zfish   363 ARFLSNTSFVGLTGPVIVQRNLSRVHTSHKVHIWSLRRDAVGQPTWVTVGSWE-GGRLNVEEQGL 426

  Fly   177 FHNATCRNRPLGVASNIFKDLMEMFYVHRVALLYANSTMNYNLLVNDYYSNVNCRILNVQSVGQ- 240
            :..::.|.|..|......:.....|.|....|.......:..:...:...:.||      ..||
Zfish   427 WQGSSPRQRTEGQMGREGRRWRAGFPVSGSRLRVVTLVEHPFVFTREVDEDGNC------PAGQY 485

  Fly   241 CHDG---------KLYPNNAVVKASM--QDYVSGFSPRNCTFFACSSISAPFVEADCILGLEMRI 294
            |.|.         .||...|....|.  .||      ..|.:..|..:.....| |.....::.|
Zfish   486 CLDAGTNSSETLDHLYAERAQGNKSFLPPDY------SKCCYGYCIDLLEKLSE-DMNFEFDLYI 543

  Fly   295 LGFMKNRLKFDVNQTCSLESRGEMDGPANWTGLLGKVQNNECDFVFGGYYPD---NEVADHFWGS 356
            :|..|               .|.:.| ..||||:|.:.:...|.....:..:   ::|.|.   :
Zfish   544 VGDGK---------------YGAVKG-GQWTGLVGDLLSGVADMAVTSFSINSARSKVIDF---T 589

  Fly   357 DTYLQDAHTWYIKMADRRPAWQALVGIFEAYTWIGFILILIISWLF-----WFTLVMILPEPK-- 414
            ..:...:....::..|......|.:.......|:|..:.|.|:.||     |.:...:.|..:
Zfish   590 SPFFSTSLGILVRSKDTAAPIGAFMWPLHWSMWMGIFVALHITALFLTLYEWKSPFGMTPHGRNR 654

  Fly   415 -----YYQQLSLTAINALAVTISIAVQERPICETTRLFFMALTLYGLNVVATYTSKMIA------ 468
                 |...|:|........|:|   .:.|.|.|.|.......::.|.|:::||:.:.|
Zfish   655 VKVFSYSSALNLCYAILFGRTVS---SKTPKCWTGRFLMNLWAIFCLLVLSSYTANLAAVMVGEK 716

  Fly   469 TFQDPGYLHQLDELTEVVAAGIPFGGHEES-------RDWFENDDDMWIFNGYNISPEFIPQSK- 525
            ||::...:|  |......:.|..||...||       :.:.|..:.|..|| ...:|:.:...|
Zfish   717 TFEEVSGIH--DAKLHHPSQGFRFGTVRESSAEDYMKKSFPEMHEYMRKFN-EPTTPDGVATLKT 778

  Fly   526 ---NLEAVKWGQRCILSNRMYTMQSPLADVIYAFPNNVFSSPVQMIMKAGFPFLFEMNSIIRLMR 587
               .|:|             :.|...|.|...:...:.      .::..|.||..|... |.|.:
Zfish   779 DPPQLDA-------------FIMDKALLDYEVSIDADC------KLLTVGKPFAIEGYG-IGLPQ 823

  Fly   588 DVGIFQKIDADF--RY-NNTYLNRIN----KMRPQFPETAIVLTT-----EHLKGPFFILVVGSC 640
            :..:...| ::|  || ::.|::.::    |:.|.......|..|     .|..|.|.:|.||..
Zfish   824 NSPLTSNI-SEFVSRYKSDGYMDMLHDKWYKVVPCGKRVFAVTETLQMGIRHFSGLFVLLCVGVT 887

  Fly   641 WAALTFIGELIIHR--------------WRTQLVSTSEQQDRRSDKRRR--RRRRRKPEKDNRWQ 689
            .|.||..||...:|              |    :.||::..|..:....  :|:|...||....|
Zfish   888 GALLTLAGEHAFYRLVLPHIRRKQKFKYW----LHTSQKIHRALNMTYEDVKRQRANTEKSCNIQ 948

  Fly   690 R-----QVQVAPVVRF 700
            :     ..|.||:..|
Zfish   949 KAQPHPPPQPAPLGSF 964

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir60a	NP_611901.1	None
grin3bb	XP_017213803.2	PBP1_iGluR_NMDA_NR3	29..428	CDD:107372	32/130 (25%)
grin3bb	XP_017213803.2	PBP2_iGluR_NMDA_Nr3	457..852	CDD:270438	85/453 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591629
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.930