DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir60a and LOC100149482

DIOPT Version :9

Sequence 1:	NP_611901.1	Gene:	Ir60a / 37881	FlyBaseID:	FBgn0034994	Length:	716	Species:	Drosophila melanogaster
Sequence 2:	XP_009290417.1	Gene:	LOC100149482 / 100149482	-ID:	-	Length:	1959	Species:	Danio rerio

Alignment Length:	702	Identity:	119/702 - (16%)
Similarity:	241/702 - (34%)	Gaps:	175/702 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 LGPDVWKAGVGCLDSFAQIFFFR------NPKERFTRAYNLMLVHAFHLSSPADQIQEGFSKLIN 102
            :||.:.:.|:..|..  ::|..|      .|:.|..|..:::...|..|..  |....|....:.
Zfish   288 VGPALSELGLTGLPK--RLFAVRPQGWRDEPRRRIARGVSILTHGAVALRK--DYGATGGPHFVT 348

  Fly   103 EAVTNPGPPDREELFQMRVASDYNITNGTED---KGELILADNYVIVVDSVDRLKELMKKKIVEM 164
            ...|:   .:|.:..:.|:....|||.|..|   ..|..||:.::.|:
Zfish   349 NCQTD---GNRTQRIRGRMRYFSNITLGGRDYSFSNEGYLANPFLDVI----------------- 393

  Fly   165 RSWNPGARF----------LVLFHNATCRNRPLGVASNIFKDLMEMFYVHRVALLYANSTMNYNL 219
             |:.||:.:          |.|.:.|..|..|.....:..:.|..:....|..::...:......
Zfish   394 -SYTPGSGWEDVGWWENGVLRLRYPAWSRYGPFLQPPDDAQHLRVVTLEERPFVIVELADAASGT 457

  Fly   220 LVNDYYSNVNCRILNVQSVGQCHDGKLYPNNAVVKASMQDYVSGFSP-RNCTFFACSSISAPFVE 283
            .:.|   :|.||               .|.||   :::|:   |.:| :.|....|..
Zfish   458 CIRD---SVPCR---------------RPLNA---SALQE---GVAPVKQCCKGFCID------- 491

  Fly   284 ADCILGLEMRILGFMKNRLKFDVNQTCSLESRGEMDGPANWTGLLGKVQNNECDFVFGGYYPDNE 348
               ||....||:||     .:|:....:.:...::||.  |.|::|:|.....|...|....:.|
Zfish   492 ---ILKRLARIVGF-----TYDLYLVTNGKHGKKIDGV--WNGMVGEVVYKRADMAIGSLTINEE 546

  Fly   349 VADHFWGSDTYLQDAHTWYIKMADRRPAWQALVGIFEAYTWI-GFILILIISWLFWFTLVMILP- 411
            .::....|..:::...:..:..::...:..|.:..:....|: .|::.|.:..:..|......|
Zfish   547 RSEVVDFSVPFVETGISVMVSRSNGTVSPSAFLEPYSPAVWVMMFVMCLTVVAVTVFIFEFFSPV 611

  Fly   412 -------------EPKYYQQLSLTAINALAVTISIAVQERPICETTRLFFMALTLYGLNVVATYT 463
                         ..|:....|:..:.||....|:.| |.|...|:::..:....:.:..:|:||
Zfish   612 GYNRSLQSGKKAGGSKFTIGKSIWLLWALVFNNSVPV-ENPKGTTSKIMVLVWAFFAVIFLASYT 675

  Fly   464 SKM------------IATFQDPGYLHQLDELTEVVAAGIPFGGHEESRDWFENDDDMWIFNGYNI 516
            :.:            ::...|..:.|..::...:....:|.|..|::           |.:.|..
Zfish   676 ANLAAFMIQEEYIDTVSGLSDKKFQHPTEQYPPLKFGTVPNGSTEKN-----------IRSNYPD 729

  Fly   517 SPEFIPQSKNLEAVKWGQRCILSNRMYTMQSPLADVIY--AFPN-----------------NVFS 562
            ..:::        ||:.|:.:.....:.....|...||  |..|                 .||:
Zfish   730 MHQYM--------VKYNQKSVEDAISHLKTGKLDAFIYDAAVLNYMARKDEGCKVMTIGSGKVFA 786

  Fly   563 SPVQMIMKAGFPFLFEMNSIIRLMRDVGIFQKIDAD--------FRYNNTYLNRINKMRPQFPET 619
            :       .|:......||..:...|:.:.|.:..|        :.....:.::|..|..:
Zfish   787 T-------TGYGIALIKNSRWKRPLDLALLQLVGDDEIEMLERLWLSGICHNDKIEVMSSK---- 840

  Fly   620 AIVLTTEHLKGPFFILVVGSCWAALTFIGELIIHRWRTQLVSTSEQQDRRSD 671
               |..:::.|.|::|:|....:.|.|..|.::: ||.:...:...|..:.|
Zfish   841 ---LDIDNMAGVFYMLLVAMGLSLLVFAWEHLVY-WRLRHCMSKMGQSGKLD 888

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir60a	NP_611901.1	None
LOC100149482	XP_009290417.1	PBP1_iGluR_NMDA_NR2	44..421	CDD:107373	31/157 (20%)
		PBP2_iGluR_NMDA_Nr2	433..831	CDD:270436	72/465 (15%)
		HisJ	<487..>570	CDD:223904	18/99 (18%)
		Lig_chan	585..857	CDD:278489	47/305 (15%)
		NMDAR2_C	868..>900	CDD:287527	4/22 (18%)
		FAM76	<1763..>1856	CDD:292665
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591618
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.830