DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CATSPER4 and cacna1ha

DIOPT Version :9

Sequence 1:	NP_937770.1	Gene:	CATSPER4 / 378807	HGNCID:	23220	Length:	472	Species:	Homo sapiens
Sequence 2:	XP_021330381.1	Gene:	cacna1ha / 560875	ZFINID:	ZDB-GENE-130103-1	Length:	2198	Species:	Danio rerio

Alignment Length:	306	Identity:	76/306 - (24%)
Similarity:	135/306 - (44%)	Gaps:	69/306 - (22%)

- Green bases have known domain annotations that are detailed below.

Human    72 DAWDMQEFITH----MYIKQLLRHPAFQLLLALLLVINAITIALRTNSYLDQKHYELFSTIDDIV 132
            :.|.:..|..|    |..::|:.|..|..::.:.:.:|.|||||. ..::.|.. .||..:.:.|
Zfish  1120 EEWSLYLFSPHNKFRMMCQKLISHKMFDYVVLVFIFLNCITIALE-RPHIQQSE-RLFLLVSNYV 1182

Human   133 LTILLCE------VLLGWLNGFWIFWKDGWNILNFIIVFILLLRFFINEINIPSINYT------- 184
            .|::...      |.||:.:|...:.|..||:|:.::||:.|:...:      |:.:|
Zfish  1183 FTVIFVAEMTVKVVALGFYSGNQSYLKSTWNVLDGVLVFVSLIDILV------SLAWTGNRIFGI 1241

Human   185 LRALRLVHVCMAVEPLAR------IIRVILQSVPDMANIMVLILFFMLVFSVFGVTLF-GAFV-- 240
            ||.|||:.....:..::|      ::..::.|:..:.||:::...|.:||.:.||.|| |.|.
Zfish  1242 LRVLRLLRTLRPLRVISRAPGLKLVVETLITSLRPIGNIVLICCAFFIVFGILGVQLFKGKFFHC 1306

Human   241 ------------------------PKHFQNIQVALYTLFICITQDGWVDI-YS-------DFQTE 273
                                    ..:|.|:..||.:||:...:||||:| |.       |.|.|
Zfish  1307 EGGDTRNITNKSDCLQANLKWIRRKYNFDNLGQALMSLFVLSCKDGWVNIMYDGLDAVGVDQQPE 1371

Human   274 KREYAMEIGGAIYFTIFITIGAFIGINLFVIVVTTNLEQMMKAGEQ 319
            :......:   :||..|:.|.:|..:|:||.||..|..:..:..|:
Zfish  1372 RNHNPWML---LYFISFLLIVSFFVLNMFVGVVVENFHKCRQDQEE 1414

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CATSPER4	NP_937770.1	Ion_trans	91..313	CDD:306908	70/275 (25%)
CATSPER4	NP_937770.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	416..438
cacna1ha	XP_021330381.1	Ion_trans	1..323	CDD:306908
		Ion_trans	644..871	CDD:306908
		Ion_trans	1143..1413	CDD:306908	70/280 (25%)
		Ion_trans	1464..1695	CDD:306908
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2301
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810