DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CATSPER4 and Catsper4

DIOPT Version :9

Sequence 1:	NP_937770.1	Gene:	CATSPER4 / 378807	HGNCID:	23220	Length:	472	Species:	Homo sapiens
Sequence 2:	NP_808534.1	Gene:	Catsper4 / 329954	MGIID:	3043288	Length:	442	Species:	Mus musculus

Alignment Length:	476	Identity:	313/476 - (65%)
Similarity:	370/476 - (77%)	Gaps:	38/476 - (7%)

- Green bases have known domain annotations that are detailed below.

Human     1 MRDNEKAWWQQW----TSHTGLEGWGGTQEDRMGFGGAVAALRGRPSPLQSTIHESYGRPEEQVL 61
            |.:..| ||||.    .:|.|                          |.:.. :|..||.|||||
Mouse     1 MSEKHK-WWQQVENIDITHLG--------------------------PKRKA-YELLGRHEEQVL 37

Human    62 INRQEITNKADAWDMQEFITHMYIKQLLRHPAFQLLLALLLVINAITIALRTNSYLDQKHYELFS 126
            |||:::..|.||||:|||||.|||||||||||||||||.||:.|||||||||||||.||||||||
Mouse    38 INRRDVMEKKDAWDVQEFITQMYIKQLLRHPAFQLLLAFLLLSNAITIALRTNSYLGQKHYELFS 102

Human   127 TIDDIVLTILLCEVLLGWLNGFWIFWKDGWNILNFIIVFILLLRFFINEINIPSINYTLRALRLV 191
            ||||||||||:||||||||||||||||||||||||.|||||.:.|||.::::.:|.|.||.||||
Mouse   103 TIDDIVLTILICEVLLGWLNGFWIFWKDGWNILNFAIVFILFMGFFIKQLDMVAITYPLRVLRLV 167

Human   192 HVCMAVEPLARIIRVILQSVPDMANIMVLILFFMLVFSVFGVTLFGAFVPKHFQNIQVALYTLFI 256
            |||||||||||||:|||||:||:||:|.|||||||||||||||||||||||||||:.||||||||
Mouse   168 HVCMAVEPLARIIKVILQSMPDLANVMALILFFMLVFSVFGVTLFGAFVPKHFQNMGVALYTLFI 232

Human   257 CITQDGWVDIYSDFQTEKREYAMEIGGAIYFTIFITIGAFIGINLFVIVVTTNLEQMMKAGEQGQ 321
            |||||||:|||:|||.::||||||:||||||.:|||:|||||:||||:|||||||||||.||:..
Mouse   233 CITQDGWLDIYTDFQMDEREYAMEVGGAIYFAVFITLGAFIGLNLFVVVVTTNLEQMMKTGEEEG 297

Human   322 QQRITFSETGAEEEEENDQLPLVHCVVARSEKSGLLQEPLAGGPLSNLSENTCDNFCLVLEAIQE 386
            ...|.|:|| .|:|:..|:||||||..||.:.|.:.:|||.|||||||:|.||||||||||||||
Mouse   298 HLNIKFTET-EEDEDWTDELPLVHCTEARKDTSTVPKEPLVGGPLSNLTEKTCDNFCLVLEAIQE 361

Human   387 NLRQYKEIRDELNMIVEEVRAIRFNQEQESEVLNRRSSTSGSLETTSSKDIRQMSQQQDLLSALV 451
            ||.:|||||:|||||||||.:|||||||::.:|::.:|.|    .|...:..:.:.:|||::|||
Mouse   362 NLMEYKEIREELNMIVEEVSSIRFNQEQQNVILHKYTSKS----ATFLSEPPEGANKQDLITALV 422

Human   452 SMEKVHDSSSQILLKKHKSSH 472
            |.|||.||:.. ::.|||.||
Mouse   423 SREKVSDSNIN-MVNKHKFSH 442

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CATSPER4	NP_937770.1	Ion_trans	91..313	CDD:306908	184/221 (83%)
CATSPER4	NP_937770.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	416..438		4/21 (19%)
Catsper4	NP_808534.1	Ion_trans	91..289	CDD:278921	163/197 (83%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C83970612
Domainoid	1	1.000	394	1.000	Domainoid score	I11561
eggNOG	1	0.900	-	-		E1_KOG2301
HGNC	1	1.500	-	-
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H18638
Inparanoid	1	1.050	608	1.000	Inparanoid score	I10497
Isobase	1	0.950	-	0	Normalized mean entropy	S11832
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG41820
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0015731
OrthoInspector	1	1.000	-	-		oto128520
orthoMCL	1	0.900	-	-		OOG6_112582
Panther	1	1.100	-	-	LDO	PTHR47077
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R12481
SonicParanoid	1	1.000	-	-		X12595
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	18	18.240