DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CATSPER4 and para

DIOPT Version :9

Sequence 1:	NP_937770.1	Gene:	CATSPER4 / 378807	HGNCID:	23220	Length:	472	Species:	Homo sapiens
Sequence 2:	NP_001259619.1	Gene:	para / 32619	FlyBaseID:	FBgn0285944	Length:	2145	Species:	Drosophila melanogaster

Alignment Length:	278	Identity:	70/278 - (25%)
Similarity:	131/278 - (47%)	Gaps:	49/278 - (17%)

- Green bases have known domain annotations that are detailed below.

Human    87 QLLRHPAFQLLLALLLVINAITIALRTNSYLDQKH--YELFSTIDDIVLTILLCEVLLGWLN-GF 148
            ||:.:..|:..:..:::::::.:||. :.:|.|:.  .::...:|.|...|...|:|:.||. ||
  Fly  1296 QLIENKYFETAVITMILMSSLALALE-DVHLPQRPILQDILYYMDRIFTVIFFLEMLIKWLALGF 1359

Human   149 WIFWKDGWNILNFIIVFILLLRFFINEINIPSIN-----YTLRALRLVHVCMAVEPLARIIRVIL 208
            .:::.:.|..|:|:||.:.|:.|..:.:....|.     .||||||.:.....::.:..::..::
  Fly  1360 KVYFTNAWCWLDFVIVMVSLINFVASLVGAGGIQAFKTMRTLRALRPLRAMSRMQGMRVVVNALV 1424

Human   209 QSVPDMANIMVLILFFMLVFSVFGVTLFGA----------------FVPK--------------- 242
            |::|.:.|::::.|.|.|:|::.||.||..                .:|.
  Fly  1425 QAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCEDMNGTKLSHEIIPNRNACESENYTWVNSA 1489

Human   243 -HFQNIQVALYTLFICITQDGWVDIYSDFQTEKREYAME------IGGAIYFTIFITIGAFIGIN 300
             :|.::..|...||...|..||:.|.:| ..:.||...:      |...:||..||..|:|..:|
  Fly  1490 MNFDHVGNAYLCLFQVATFKGWIQIMND-AIDSREVDKQPIRETNIYMYLYFVFFIIFGSFFTLN 1553

Human   301 LFVIVVTTNL-EQMMKAG 317
            ||:.|:..|. ||..|||
  Fly  1554 LFIGVIIDNFNEQKKKAG 1571

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CATSPER4	NP_937770.1	Ion_trans	91..313	CDD:306908	64/268 (24%)
CATSPER4	NP_937770.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	416..438
para	NP_001259619.1	Ion_trans	165..436	CDD:278921
		Na_trans_cytopl	515..648	CDD:288761
		Ion_trans	835..1028	CDD:278921
		Na_trans_assoc	1054..1296	CDD:284034	70/278 (25%)
		Ion_trans	1318..1571	CDD:278921	65/254 (26%)
		Na_channel_gate	1561..1613	CDD:240441	6/11 (55%)
		Ion_trans	1636..1871	CDD:278921
		GPHH	1880..1930	CDD:293510
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2301
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810