DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CATSPER4 and cacna1g

DIOPT Version :9

Sequence 1:	NP_937770.1	Gene:	CATSPER4 / 378807	HGNCID:	23220	Length:	472	Species:	Homo sapiens
Sequence 2:	XP_031750725.1	Gene:	cacna1g / 100497283	XenbaseID:	XB-GENE-993391	Length:	2361	Species:	Xenopus tropicalis

Alignment Length:	375	Identity:	80/375 - (21%)
Similarity:	153/375 - (40%)	Gaps:	84/375 - (22%)

- Green bases have known domain annotations that are detailed below.

Human    26 EDRMGFGGAVAALRGRPSPLQSTIHESYGRP------EEQVLINRQE-----ITNKADAWDMQEF 79
            :.|....|......|:.||:...:|....:.      ::.|.::|.|     |.:...||..:..
Frog  1140 QSRHSLPGEYQDCNGKTSPVFPPLHVEESKVDYSNNIDDDVNMSRGERLKAWIISHLPAWCKERE 1204

Human    80 ITHMYI-----------KQLLRHPAFQLLLALLLVINAITIALRTNSYLDQKHYELFSTIDDIVL 133
            ...:|:           .:::.|..|..::.:::.:|.||||:............:|.|:.:.:.
Frog  1205 TWSLYLFPPYSKFRLMCNKIITHRMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIF 1269

Human   134 T-ILLCE-----VLLGWLNGFWIFWKDGWNILNFIIVFILLLRFFINEIN--------IPSINYT 184
            | |.|.|     |.:.:..|...:.:..||:|:.::|.|.::...::.::        :..:...
Frog  1270 TLIFLAEMTVKVVAMNFCFGGKAYLRSSWNVLDGMLVLISVIDILVSMVSDSGTKILGMLRVLRL 1334

Human   185 LRALRLVHVCMAVEPLARIIRVILQSVPDMANIMVLILFFMLVFSVFGVTLF-GAFV-------- 240
            ||.||.:.|....:.|..::..::.|:..:.||:|:...|.::|.:.||.|| |.|.
Frog  1335 LRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFYYCQGEDTR 1399

Human   241 ---------------PKH---FQNIQVALYTLFICITQDGWVDIYSDFQTEKREYAMEIGGA--- 284
                           .:|   |.|:..||.:||:..::||||||..|        .::..|.
Frog  1400 NITNKSDCLENKYKWARHKYNFDNLGQALMSLFVLASKDGWVDIMYD--------GLDAVGVDQQ 1456

Human   285 ----------IYFTIFITIGAFIGINLFVIVVTTNLEQMMKAGEQGQQQR 324
                      :||..|:.|.||..:|:||.||..|..:..:..|:.:.:|
Frog  1457 PVMNYNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEAKR 1506

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CATSPER4	NP_937770.1	Ion_trans	91..313	CDD:306908	65/275 (24%)
CATSPER4	NP_937770.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	416..438
cacna1g	XP_031750725.1	Ion_trans	52..375	CDD:395416
		Ion_trans	703..932	CDD:395416
		Ion_trans	1227..1499	CDD:395416	65/279 (23%)
		Ion_trans	1568..1809	CDD:395416
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000