DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CATSPER4 and scn2a

DIOPT Version :9

Sequence 1:	NP_937770.1	Gene:	CATSPER4 / 378807	HGNCID:	23220	Length:	472	Species:	Homo sapiens
Sequence 2:	XP_031749252.1	Gene:	scn2a / 100486750	XenbaseID:	XB-GENE-6447552	Length:	1970	Species:	Xenopus tropicalis

Alignment Length:	306	Identity:	73/306 - (23%)
Similarity:	133/306 - (43%)	Gaps:	60/306 - (19%)

- Green bases have known domain annotations that are detailed below.

Human    62 INRQEITNKADAWDMQEFITHMYIKQLLRHPAFQLLLALLLVINAITIALRTNSYLDQKH--YEL 124
            ||.:..|.: |.|::::     ....::.|..|:..:..::::::..:|.. :.|::|:.  ..:
Frog  1156 INIENGTGR-DWWNLRK-----TCYTIVEHSWFESFIIFMILLSSGALAFE-DIYVEQRRNVKAI 1213

Human   125 FSTIDDIVLTILLCEVLLGWL-NGFWIFWKDGWNILNFIIVFILLLRFFINEIN------IPSIN 182
            ....|.:...|.:.|:||.|: .||..::.:.|..|:||||.|.|:....|.:.      |.|:.
Frog  1214 LEYADKVFAYIFIMEMLLKWVAYGFIKYFTNAWCWLDFIIVDISLVSLIANALGYSELGAIKSLR 1278

Human   183 YTLRALRLVHVCMAVEPLARIIRVILQSVPDMANIMVLILFFMLVFSVFGVTLF-GAF------- 239
             ||||||.:......|.:..::..::.::|.:.|::::.|.|.|:||:.||.|| |.|
Frog  1279 -TLRALRPLRALSRFEGMRVVVNALIGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYYCVNTT 1342

Human   240 ------------------------------VPKHFQNIQVALYTLFICITQDGWVDI-YSDFQT- 272
                                          |..:|.|:......|....|..||:.| |:...:
Frog  1343 SGVPFPATDVNNYSDCRMYINTTGAARWKNVKVNFDNVGAGYLALLQVATFKGWMPIMYAAVDSR 1407

Human   273 ---EKREYAMEIGGAIYFTIFITIGAFIGINLFVIVVTTNLEQMMK 315
               |:.:|.......:||..||..|:|..:|||:.|:..|..|..|
Frog  1408 EINEQPKYENNTTMYLYFVAFIIFGSFFTLNLFIGVIIDNFNQQKK 1453

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CATSPER4	NP_937770.1	Ion_trans	91..313	CDD:306908	66/273 (24%)
CATSPER4	NP_937770.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	416..438
scn2a	XP_031749252.1	Ion_trans	127..408	CDD:395416
		Na_trans_cytopl	488..678	CDD:403218
		Ion_trans	727..940	CDD:395416
		Na_trans_assoc	966..1175	CDD:399489	5/24 (21%)
		Ion_trans	1179..1454	CDD:395416	68/277 (25%)
		Na_channel_gate	1446..1498	CDD:240441	3/8 (38%)
		Ion_trans	1503..1758	CDD:395416
		GPHH	1770..1817	CDD:407139
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000