DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CATSPER4 and scn3a

DIOPT Version :9

Sequence 1:	NP_937770.1	Gene:	CATSPER4 / 378807	HGNCID:	23220	Length:	472	Species:	Homo sapiens
Sequence 2:	XP_012826714.1	Gene:	scn3a / 100125099	XenbaseID:	XB-GENE-5812330	Length:	2019	Species:	Xenopus tropicalis

Alignment Length:	296	Identity:	71/296 - (23%)
Similarity:	134/296 - (45%)	Gaps:	63/296 - (21%)

- Green bases have known domain annotations that are detailed below.

Human    74 WDMQE--FITHMYIKQLLRHPAFQLLLALLLVINAITIALRTNSYLDQ-KHYELFSTIDDIVLT- 134
            |::::  |:       ::.|..|:..:..::::::..:|.. :.|::| |..::.....|.|.|
Frog  1209 WNLRKTCFL-------IVEHNWFETFIIFMILMSSGALAFE-DIYIEQRKTIKIILEYADKVFTY 1265

Human   135 ILLCEVLLGWL-NGFWIFWKDGWNILNFIIVFILLLRFFINEIN------IPSINYTLRALRLVH 192
            |.:.|:||.|: .||..::.:.|..|:|:||.:.|:....|.:.      |.|:. ||||||.:.
Frog  1266 IFILEMLLKWVAYGFQKYFTNAWCWLDFLIVDVSLVSLIANALGYSELGAIKSLR-TLRALRPLR 1329

Human   193 VCMAVEPLARIIRVILQSVPDMANIMVLILFFMLVFSVFGVTLF-GAF----------------- 239
            .....|.:..::..::.::|.:.|::::.|.|.|:||:.||.:| |.:
Frog  1330 ALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNMFSGKYGYCVNYTDDVVFDYTIV 1394

Human   240 --------------------VPKHFQNIQVALYTLFICITQDGWVDI-YSDFQTEKRE----YAM 279
                                |..:|.|:......|....|..||::| |:...:.|:|    |..
Frog  1395 NNRSQCMDLISENKTARWKNVKVNFDNVGFGYLALLQVATFKGWMEIMYAAVDSRKQEEQPKYED 1459

Human   280 EIGGAIYFTIFITIGAFIGINLFVIVVTTNLEQMMK 315
            .:...:||.|||..|:|..:|||:.|:..|..|..|
Frog  1460 NLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKK 1495

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CATSPER4	NP_937770.1	Ion_trans	91..313	CDD:306908	67/273 (25%)
CATSPER4	NP_937770.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	416..438
scn3a	XP_012826714.1	Ion_trans	151..430	CDD:278921
		Na_trans_cytopl	512..627	CDD:288761
		Ion_trans	786..982	CDD:278921
		Na_trans_assoc	1008..1216	CDD:284034	1/6 (17%)
		Ion_trans	1239..1496	CDD:278921	67/259 (26%)
		Na_channel_gate	1488..1540	CDD:240441	3/8 (38%)
		Ion_trans	1562..1800	CDD:278921
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910