Protein Alignment KCNS2 and Shawl

DIOPT Version :10

• Sequence 1: NP_065748.1
• Gene: KCNS2 / 3788
• HGNCID: 6301
• Length: 477
• Species: Homo sapiens
• Sequence 2: NP_001097131.2
• Gene: Shawl / 5740840
• FlyBaseID: FBgn0085395
• Length: 937
• Species: Drosophila melanogaster
• Alignment Length: 529
• Identity: 153/529 - (28%)
• Similarity: 231/529 - (43%)
• Gaps: 155/529 - (29%)

Human    16 DGEIRI--NVGGFKRRLRSHTLLRFPETRLGRLLLCHSREAILELCDDYDDVQREFYFDRNPELF 78
            |||.||  ||.|.:......||.:.|.|||.||         .|...:||.|..|::|||:|.:|
  Fly     2 DGENRIILNVSGIRYETYKATLKKIPATRLSRL---------TEALANYDPVLNEYFFDRHPGVF 57

Human    79 PYVLHFYHTGKLHVMAELCVFSFSQEIEYWGINEFFIDSCC--SYSYHG---------RKVEPEQ 132
            ..:|::|.|||||...::|...|.:|:|:||::...::.||  :||.|.         .|::.|.
  Fly    58 TQILNYYRTGKLHYPTDVCGPLFEEELEFWGLDSNQVEPCCWSTYSIHRDTQNTLAILDKLDIEN 122

Human   133 EKWDEQSDQESTTSSFDEILAFYNDASKFDGQPLGNFRR---QLWLALDNPGYSVLSRVFSILSI 194
            ||..|  :|.:....|:|.|:        :|: |..::|   ::|...|.|..|..:::.:.:|:
  Fly   123 EKPTE--EQIARLFGFEEALS--------NGE-LNCWQRIKPKIWAMFDEPSSSTGAKIVAGMSV 176

Human   195 LVVMGSIITMCLNSLPDFQI-----------PDSQGNP-GEDPRFE------------------- 228
            ..:..|:|:.||.:.|.|::           |.:.|.| |.||..|
  Fly   177 FFIFVSVISFCLKTHPGFRVDLPSGAHDAHGPGAGGPPHGHDPMGEPPQTHQYHQHSITPPSGSI 241

Human   229 -----------------------------------------------------IVEHFG------ 234
                                                                 |:.|.|
  Fly   242 GPTFRVTNYTSYSSGNFTASGQATPIATIKGGQRQRLKRNINGSILNEFIEEKILGHNGRRKHGW 306

Human   235 ------------------IAWFTFELVARFAVAPDFLKFFKNALNLIDLMSIVPFYITLVVNLVV 281
                              ..||..|::.|..|:|:..:|.|:.:|:||..:.:.|| |.|:..:.
  Fly   307 IETYGQPHEAFFYVELVCNVWFFIEVIIRLIVSPNLWQFIKSPVNIIDFTATLSFY-TDVMQRMG 370

Human   282 ESTPTLANLGRVAQVLRLMRIFRILKLARHSTGLRSLGATLKYSYKEVGLLLLYLSVGISIFSVV 346
            |.|..|       :...::||.|:.||.|||.|||.|..|.|.|.||:.||:.:|.:||..|:.:
  Fly   371 EYTGLL-------EAFSIVRIMRLFKLTRHSPGLRILIHTFKASAKELTLLVFFLVLGIVFFASL 428

Human   347 AYTIEK-EEN--EGLATIPACWWWATVSMTTVGYGDVVPGTTAGKLTASACILAGILVVVLPITL 408
            ||..|| ::|  ....:||...|||.|:|||||||||.|.|..|....:.|.|||:|.:.||:.:
  Fly   429 AYYAEKLQDNPDNQFKSIPLGLWWAIVTMTTVGYGDVAPKTYPGMFVGALCALAGVLTIALPVPV 493

Human   409 IFNKFSHFY 417
            |.:.||.||
  Fly   494 IVSNFSMFY 502

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KCNS2	NP_065748.1	BTB_POZ_KCNS2	18..124	CDD:349734	41/109 (38%)
		Ion_trans	186..421	CDD:459842	93/343 (27%)
		Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142	374..379		4/4 (100%)
Shawl	NP_001097131.2	BTB_Shaw-like	4..115	CDD:349723	42/119 (35%)
		Ion_trans	307..506	CDD:459842	76/204 (37%)